Amino acids as regulators of gene expression (Q24562847)

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

Europe PubMed Central

title

Amino acids as regulators of gene expression (English)

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Scot R Kimball

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Leonard S Jefferson

series ordinal

2

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language of work or name

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2004

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published in

Nutrition and Metabolism

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volume

1

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issue

1

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page(s)

3

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cites work

1 reference

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

24 March 2017

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

24 March 2017

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Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

24 March 2017

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The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3

24 March 2017

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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

24 March 2017

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

24 March 2017

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

24 March 2017

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Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin

24 March 2017

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The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR

24 March 2017

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TSC2 mediates cellular energy response to control cell growth and survival

24 March 2017

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

24 March 2017

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GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

24 March 2017

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The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr

24 March 2017

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

24 March 2017

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Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

24 March 2017

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

24 March 2017

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LKB1--a master tumour suppressor of the small intestine and beyond

24 March 2017

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Hepatic amino acid-dependent signaling is under the control of AMP-dependent protein kinase

24 March 2017

1 reference

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AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

24 March 2017

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Gene-specific regulation by general translation factors

24 March 2017

1 reference

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Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome

24 March 2017

1 reference

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Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent manner

24 March 2017

1 reference

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Deficiency of dietary EAA preferentially inhibits mRNA translation of ribosomal proteins in liver of meal-fed rats

24 March 2017

1 reference

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Internal ribosome entry sites in eukaryotic mRNA molecules

24 March 2017

1 reference

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Translational control is required for the unfolded protein response and in vivo glucose homeostasis

24 March 2017

1 reference

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Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

24 March 2017

1 reference

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

24 March 2017

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Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes

24 March 2017

1 reference

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Akt regulates growth by directly phosphorylating Tsc2

24 March 2017

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Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

7 April 2017

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TSC2: filling the GAP in the mTOR signaling pathway

7 April 2017

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Assembly of 48S translation initiation complexes from purified components with mRNAs that have some base pairing within their 5' untranslated regions.

27 September 2017

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Rhebbing up mTOR: New Insights on TSC1 and TSC2, and the Pathogenesis of Tuberous Sclerosis

27 September 2017

1 reference

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Rheb fills a GAP between TSC and TOR.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524028

Tumor specific activation of PKR as a non-toxic modality of cancer treatment

27 September 2017

1 reference

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

27 September 2017

1 reference

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LKB1, a protein kinase regulating cell proliferation and polarity

27 September 2017

1 reference

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Tumour suppressors hamartin and tuberin: intracellular signalling

27 September 2017

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When translation meets metabolism: multiple links to diabetes

27 September 2017

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Eukaryotic translation initiation factors and regulators

27 September 2017

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Tuberous sclerosis: from tubers to mTOR.

27 September 2017

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Distinct regulation of internal ribosome entry site-mediated translation following cellular stress is mediated by apoptotic fragments of eIF4G translation initiation factor family members eIF4GI and p97/DAP5/NAT1.

27 September 2017

1 reference

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Growth signaling: TSC takes its place.

27 September 2017

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Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

27 September 2017

1 reference

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The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice

27 September 2017

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Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

27 September 2017

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Control of eukaryotic protein synthesis by upstream open reading frames in the 5'-untranslated region of an mRNA

27 September 2017

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S6 phosphorylation-independent pathways regulate translation of 5'-terminal oligopyrimidine tract-containing mRNAs in differentiating hematopoietic cells

27 September 2017

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Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

27 September 2017

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TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

27 September 2017

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Internal ribosome initiation of translation and the control of cell death.

27 September 2017

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Iron-regulatory proteins, iron-responsive elements and ferritin mRNA translation

27 September 2017

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The role of the 5' untranslated region of an mRNA in translation regulation during development

27 September 2017

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Attenuation of mammalian target of rapamycin activity by increased cAMP in 3T3-L1 adipocytes

27 September 2017

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cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells

27 September 2017

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Defective translational control facilitates vesicular stomatitis virus oncolysis

27 September 2017

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Eukaryotic mRNAs encoding abundant and scarce proteins are statistically dissimilar in many structural features

30 May 2018

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PKR--a protein kinase regulated by double-stranded RNA.

30 May 2018

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Partial purification of a translational repressor mediating hemin control of globin synthesis and implication of results on the site of inhibition

30 May 2018

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Purification, phosphorylation and control of the guanine-nucleotide-exchange factor from rabbit reticulocyte lysates

30 May 2018

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The mTOR signaling pathway mediates control of ribosomal protein mRNA translation in rat liver

30 May 2018

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Phosphorylation of eukaryotic translation initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy.

28 November 2018

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TSC1 and TSC2: genes that are mutated in the human genetic disorder tuberous sclerosis

28 November 2018

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TSC1–TSC2: a complex tale of PKB-mediated S6K regulation

28 November 2018

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Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes

28 November 2018

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Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2alpha phosphorylation and translation of a small upstream open reading frame

28 November 2018

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Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

28 November 2018

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The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

28 November 2018

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28 November 2018

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Feeding stimulates protein synthesis in muscle and liver of neonatal pigs through an mTOR-dependent process.

28 November 2018

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Implication of eIF2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts

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12 December 2020

Modulation of rabbit reticulocyte guanine nucleotide exchange factor activity by casein kinases 1 and 2 and glycogen synthase kinase 3

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Mechanism of inhibition of peptide chain initiation by amino acid deprivation in perfused rat liver. Regulation involving inhibition of eukaryotic initiation factor 2 alpha phosphatase activity

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Phosphorylation of the guanine nucleotide exchange factor and eukaryotic initiation factor 2 by casein kinase II regulates guanine nucleotide binding and GDP/GTP exchange

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12 December 2020