Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks (Q24599990)

1

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Resmi Pillai

2

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Li Deng

3

0 references

Li Liang

4

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Sandy J Schwemberger

6

0 references

George F Babcock

7

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Peter J Stambrook

Stem Cells and Development

8

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language of work or name

English

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publication date

November 2010

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published in

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volume

19

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issue

11

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page(s)

1699-711

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cites work

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DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells

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Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation

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Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase

24 March 2017

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Embryonic stem cells and somatic cells differ in mutation frequency and type

24 March 2017

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The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

24 March 2017

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XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

24 March 2017

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The involvement of key DNA repair pathways in the formation of chromosome rearrangements in embryonic stem cells

24 March 2017

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An Msh2 point mutation uncouples DNA mismatch repair and apoptosis

24 March 2017

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The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants

24 March 2017

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Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication

24 March 2017

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DNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining system

24 March 2017

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DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

24 March 2017

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The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage

24 March 2017

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Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

24 March 2017

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Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

24 March 2017

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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

24 March 2017

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Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings

24 March 2017

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A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

7 April 2017

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Targeted disruption of the Rad51 gene leads to lethality in embryonic mice

7 April 2017

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The management of adult soft tissue sarcomas

7 April 2017

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The role of adjuvant radiation in endometrial cancer.

27 September 2017

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27 September 2017

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Chemoradiotherapy in locally advanced, unresectable non-small cell lung cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Radiotherapy in adrenocortical carcinoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Dependence of DNA double strand break repair pathways on cell cycle phase in human lymphoblastoid cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Survival responses of human embryonic stem cells to DNA damage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Comparison of nonhomologous end joining and homologous recombination in human cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Human embryonic stem cells have enhanced repair of multiple forms of DNA damage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Low levels of DNA ligases III and IV sufficient for effective NHEJ.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Microhomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Human DNA ligase IV and the ligase IV/XRCC4 complex: analysis of nick ligation fidelity.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Cell cycle control of embryonic stem cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Monoubiquitination of the nonhomologous end joining protein XRCC4.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Alternative pathways for the repair of RAG-induced DNA breaks

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

E2F target genes: unraveling the biology

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

DNA end joining becomes less efficient and more error-prone during cellular senescence

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

The role of somatic and germline mutations in aging and a mutation interaction model of aging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Ku complex controls the replication time of DNA in telomere regions.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Analysis of the cell cycle in mouse embryonic stem cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

In vivo association of Ku with mammalian origins of DNA replication

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Ku acts in a unique way at the mammalian telomere to prevent end joining

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Somatic cell mutations: can they provide a link between aging and cancer?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Transcriptional properties of genomic transgene integration sites marked by electroporation or retroviral infection

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

The somatic mutation theory of ageing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Mouse embryonic stem cells exhibit high levels of extrachromosomal homologous recombination in a chloramphenicol acetyltransferase assay system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Efficient transformation and frequent single-site, single-copy insertion of DNA can be obtained in mouse erythroleukemia cells transformed by electroporation.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Ku is involved in cell growth, DNA replication and G1-S transition.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Involvement of Ku80 in microhomology-mediated end joining for DNA double-strand breaks in vivo.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Establishment of histone gene regulation and cell cycle checkpoint control in human embryonic stem cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Utility of a C57BL/6 ES line versus 129 ES lines for targeted mutations in mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Rescue of Xrcc1 knockout mouse embryo lethality by transgene-complementation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Retinoic acid inhibits leukemia inhibitory factor signaling pathways in mouse embryonic stem cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128311

Low joining efficiency and non-conservative repair of two distant double-strand breaks in mouse embryonic stem cells

28 November 2018

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12 December 2020

Radiation therapy for head and neck cancers

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12 December 2020

P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells

1 reference

12 December 2020

Differential DNA Binding of Ku Antigen Determines Its Involvement in DNA Replication

1 reference

12 December 2020

Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblasts

1 reference

12 December 2020

Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage Version 7

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12 December 2020

Identifiers

DOI

10.1089/SCD.2010.0058

1 reference

2436827

2436827

1 reference

1 reference

1 reference