Skp2: a novel potential therapeutic target for prostate cancer (Q24625558)

Europe PubMed Central

title

Skp2: a novel potential therapeutic target for prostate cancer (English)

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1 reference

7

Fazlul H Sarkar

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Hiroyuki Inuzuka

4

object named as

Hiroyuki Inuzuka

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Wenyi Wei

8

object named as

Wenyi Wei

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Lixin Wan

6

object named as

Lixin Wan

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author name string

Zhiwei Wang

1

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Daming Gao

2

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Hidefumi Fukushima

3

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Pengda Liu

Biochimica et Biophysica Acta

5

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language of work or name

English

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publication date

January 2012

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published in

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volume

1825

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issue

1

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page(s)

11-7

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cites work

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Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

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The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells

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p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

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Androgen suppresses proliferation of castration-resistant LNCaP 104-R2 prostate cancer cells through androgen receptor, Skp2, and c-Myc

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Androgens repress expression of the F-box protein Skp2 via p107 dependent and independent mechanisms in LNCaP prostate cancer cells

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1,2,3,4,6-penta-O-galloyl-β-D-glucose, quercetin, curcumin and lycopene induce cell-cycle arrest in MDA-MB-231 and BT474 cells through downregulation of Skp2 protein

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Skp2 overexpression is associated with loss of BRCA2 protein in human prostate cancer

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SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells.

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Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells

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Molecular genetics of prostate cancer: new prospects for old challenges

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Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails

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WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells

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27 September 2017

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27 September 2017

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27 September 2017

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Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination

27 September 2017

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Up-regulation of Skp2 after prostate cancer cell adhesion to basement membranes results in BRCA2 degradation and cell proliferation

27 September 2017

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Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation

27 September 2017

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Sonic Hedgehog signaling in advanced prostate cancer

27 September 2017

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Growth factors involved in prostate carcinogenesis.

27 September 2017

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Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

27 September 2017

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27 September 2017

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27 September 2017

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Androgens repress Bcl-2 expression via activation of the retinoblastoma (RB) protein in prostate cancer cells

27 September 2017

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Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm

27 September 2017

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27 September 2017

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27 September 2017

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Skp2 regulates Myc protein stability and activity

27 September 2017

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Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate

27 September 2017

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27 September 2017

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Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins

27 September 2017

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Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma

27 September 2017

1 reference

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The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomy

27 September 2017

1 reference

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Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition

30 May 2018

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F-box protein Skp2: a novel transcriptional target of E2F.

30 May 2018

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Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.

30 May 2018

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Enhanced expression of the c-myc protooncogene in high-grade human prostate cancers

30 May 2018

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Correlation between Skp2 expression and nodal metastasis in stage I and II oral squamous cell carcinomas.

30 May 2018

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Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1.

28 November 2018

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Transcriptional activation of Skp2 by BCR-ABL in K562 chronic myeloid leukemia cells

28 November 2018

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Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells.

28 November 2018

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High-level Skp2 expression in pancreatic ductal adenocarcinoma: correlation with the extent of lymph node metastasis, higher histological grade, and poorer patient outcome

28 November 2018

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PI3K/Akt signaling regulates p27(kip1) expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27(kip1) regulation in LNCaP and PC346 cells

28 November 2018

1 reference

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The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription

28 November 2018

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Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis

28 November 2018

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Loss of the cyclin-dependent kinase inhibitor p27(Kip1) protein in human prostate cancer correlates with tumor grade

28 November 2018

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12 December 2020

Inverse relationship between Skp2 ubiquitin ligase and the cyclin dependent kinase inhibitor p27Kip1 in prostate cancer

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12 December 2020

Expression of Skp2, a p27(Kip1) ubiquitin ligase, in malignant lymphoma: correlation with p27(Kip1) and proliferation index

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12 December 2020

[Correlation of Skp2 and P27kip1 protein expression and clinicopathological features of prostate cancer]

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12 December 2020

Expression of the c-myc protooncogene in human prostatic carcinoma and benign prostatic hyperplasia

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12 December 2020

10.1016/J.BBCAN.2011.09.002

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

21963805

1 reference