Genomic views of STAT function in CD4+ T helper cell differentiation (Q24628039)

Europe PubMed Central

title

Genomic views of STAT function in CD4+ T helper cell differentiation (English)

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1 reference

2

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Yuka Kanno

5

object named as

Yuka Kanno

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Arian Laurence

object named as

Arian Laurence

4

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Golnaz Vahedi

3

object named as

Golnaz Vahedi

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author name string

John J O'Shea

Nature Reviews Immunology

1

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language of work or name

English

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publication date

April 2011

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published in

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volume

11

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page(s)

239-50

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issue

4

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cites work

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IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Widespread transcription at neuronal activity-regulated enhancers

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Differentiation of effector CD4 T cell populations (*)

7 April 2017

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The regulation of IL-10 production by immune cells

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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

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Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

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7 April 2017

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Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing

7 April 2017

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Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

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The mammalian epigenome

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7 April 2017

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7 April 2017

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Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease

7 April 2017

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Molecular signals of epigenetic states

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Linking cell signaling and the epigenetic machinery

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Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease

27 September 2017

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Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation

27 September 2017

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Regulation of microRNA expression and abundance during lymphopoiesis

27 September 2017

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Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.

27 September 2017

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Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset

27 September 2017

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Variation in transcription factor binding among humans

27 September 2017

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Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex

27 September 2017

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Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells

27 September 2017

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Biology of interleukin-22.

27 September 2017

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Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanism

27 September 2017

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Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors

27 September 2017

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Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

27 September 2017

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Lineage specification and heterogeneity of T follicular helper cells

27 September 2017

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Finding distal regulatory elements in the human genome

27 September 2017

1 reference

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CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner.

27 September 2017

1 reference

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Natural killer cell is a major producer of interferon gamma that is critical for the IL-12-induced anti-tumor effect in mice

27 September 2017

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Mapping accessible chromatin regions using Sono-Seq

27 September 2017

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Nine lives: plasticity among T helper cell subsets

27 September 2017

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Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

27 September 2017

1 reference

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Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome

27 September 2017

1 reference

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Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts

27 September 2017

1 reference

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Characterization of human epigenomes

27 September 2017

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RUNX proteins in transcription factor networks that regulate T-cell lineage choice

27 September 2017

1 reference

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Investigation of association of the IL12B and IL23R genes with psoriatic arthritis

27 September 2017

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ChromaSig: a probabilistic approach to finding common chromatin signatures in the human genome

27 September 2017

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Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells

27 September 2017

1 reference

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Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression

27 September 2017

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Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding

27 September 2017

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Single-molecule DNA sequencing technologies for future genomics research

27 September 2017

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Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

27 September 2017

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Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases

27 September 2017

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STAT6 Inhibits TGF-beta1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Stat3 and Stat4 direct development of IL-17-secreting Th cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

The JAK-STAT signaling pathway: input and output integration

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Nonredundant roles for Stat5a/b in directly regulating Foxp3

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Early target genes of IL-12 and STAT4 signaling in th cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sites

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Biologic consequences of Stat1-independent IFN signaling.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Stat1-independent regulation of gene expression in response to IFN-gamma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Roles of STAT3 defined by tissue-specific gene targeting

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming.

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Milder clinical hyperimmunoglobulin E syndrome phenotype is associated with partial interleukin-17 deficiency

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Evidence for genetic association and interaction between the TYK2 and IRF5 genes in systemic lupus erythematosus

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Identification of novel Stat6 regulated proteins in IL-4-treated mouse lymphocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Variant form of STAT4 is associated with primary Sjögren's syndrome

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiency

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Identification of novel IL-4/Stat6-regulated genes in T lymphocytes.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070307

Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of suppressor of cytokine signaling 3 expression

28 November 2018

1 reference

Stat5 activation plays a critical role in Th2 differentiation

31 March 2020

1 reference

IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state

31 March 2020

1 reference

Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity

31 March 2020

1 reference

Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation

31 March 2020

1 reference

The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4

31 March 2020

1 reference

Defective lymphoid development in mice lacking Jak3

31 March 2020

1 reference

Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3

31 March 2020

1 reference

Essential Role for STAT5 Signaling in CD25+CD4+ Regulatory T Cell Homeostasis and the Maintenance of Self-Tolerance

31 March 2020

1 reference

Cohesins bind to preferential sites along yeast chromosome III, with differential regulation along arms versus the centric region

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI2958

1 reference

4115454

4115454

1 reference

1 reference

1 reference