The role of the ribosome in the regulation of longevity and lifespan extension (Q26770848)

Wiley interdisciplinary reviews. RNA

PubMed

published in

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The economics of ribosome biosynthesis in yeast

PubMed

volume

7

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issue

2

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page(s)

198-212

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cites work

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Eukaryotic ribosome biogenesis at a glance

21 January 2018

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mTOR signaling in growth control and disease

21 January 2018

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Regulation mechanisms and signaling pathways of autophagy

21 January 2018

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Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

21 January 2018

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Extension of chronological life span in yeast by decreased TOR pathway signaling

21 January 2018

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

21 January 2018

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Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

21 January 2018

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Gene expression analysis of mTOR pathway: association with human longevity

21 January 2018

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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

21 January 2018

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Rapamycin extends murine lifespan but has limited effects on aging

21 January 2018

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Ribosomal protein mutations induce autophagy through S6 kinase inhibition of the insulin pathway

21 January 2018

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Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis

21 January 2018

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Autophagy genes are essential for dauer development and life-span extension in C. elegans

21 January 2018

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Autophagy regulates ageing in C. elegans.

21 January 2018

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The Akt of translational control

21 January 2018

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mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.

21 January 2018

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Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

21 January 2018

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Defining the role of mTOR in cancer

21 January 2018

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Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans).

21 January 2018

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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

21 January 2018

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Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.

21 January 2018

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Active regulator of SIRT1 is required for ribosome biogenesis and function.

21 January 2018

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Regulation of SirT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability

21 January 2018

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Epigenetic control of rDNA loci in response to intracellular energy status

21 January 2018

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Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

21 January 2018

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NAD⁺ metabolism: a therapeutic target for age-related metabolic disease

21 January 2018

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Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.

21 January 2018

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The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

21 January 2018

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The circadian clock coordinates ribosome biogenesis

21 January 2018

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Circadian rhythms, aging, and life span in mammals

21 January 2018

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Longitudinal epigenetic and gene expression profiles analyzed by three-component analysis reveal down-regulation of genes involved in protein translation in human aging

21 January 2018

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Abundance of ribosomal RNA gene copies maintains genome integrity

21 January 2018

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Recombination Regulation by Transcription-Induced Cohesin Dissociation in rDNA Repeats

21 January 2018

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Ribosomal DNA and cellular senescence: new evidence supporting the connection between rDNA and aging

21 January 2018

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How does genome instability affect lifespan?: roles of rDNA and telomeres

21 January 2018

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Ribosomal RNA gene repeats, their stability and cellular senescence

21 January 2018

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

21 January 2018

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Extrachromosomal rDNA circles--a cause of aging in yeast

21 January 2018

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Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis

21 January 2018

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Age-associated molecular changes in the kidney in aged mice

21 January 2018

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Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

21 January 2018

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An approach to analyse the specific impact of rapamycin on mRNA-ribosome association

21 January 2018

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Longevity, aging and rapamycin

21 January 2018

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Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo.

21 January 2018

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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

21 January 2018

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Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

21 January 2018

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 January 2018

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Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

21 January 2018

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Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans

21 January 2018

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Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones

21 January 2018

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Small heat-shock proteins: important players in regulating cellular proteostasis

21 January 2018

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Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans

21 January 2018

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HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity

21 January 2018

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The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

21 January 2018

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A C. elegans mutant that lives twice as long as wild type

21 January 2018

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FoxO transcription factors in the maintenance of cellular homeostasis during aging

21 January 2018

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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

21 January 2018

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DAF-16 target genes that control C. elegans life-span and metabolism.

21 January 2018

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LC-MS proteomics analysis of the insulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism

21 January 2018

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Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism

21 January 2018

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Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease

21 January 2018

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A short history of nitroglycerine and nitric oxide in pharmacology and physiology

21 January 2018

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Nitric oxide and another potent vasodilator are formed from NG-hydroxy-L-arginine by cultured endothelial cells

21 January 2018

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A perinatal nitric oxide donor increases renal vascular resistance and ameliorates hypertension and glomerular injury in adult fawn-hooded hypertensive rats

21 January 2018

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Nitric oxide-dependent ribosomal RNA cleavage is associated with inhibition of ribosomal peptidyl transferase activity in ANA-1 murine macrophages

21 January 2018

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Perinatal exogenous nitric oxide in fawn-hooded hypertensive rats reduces renal ribosomal biogenesis in early life

21 January 2018

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Nitric oxide induces heat-shock protein 70 expression in vascular smooth muscle cells via activation of heat shock factor 1

21 January 2018

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Complex inhibitory effects of nitric oxide on autophagy

21 January 2018

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Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons.

21 January 2018

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Autophagy activation by interferon-γ via the p38 mitogen-activated protein kinase signalling pathway is involved in macrophage bactericidal activity

21 January 2018

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Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

21 January 2018

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Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan

21 January 2018

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Widespread Proteome Remodeling and Aggregation in Aging C. elegans

21 January 2018

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Widespread protein aggregation as an inherent part of aging in C. elegans

21 January 2018

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Changes in gene expression associated with developmental arrest and longevity in Caenorhabditis elegans.

21 January 2018

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Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression

21 January 2018

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Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum

21 January 2018

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Autophagy protects C. elegans against necrosis during Pseudomonas aeruginosa infection

21 January 2018

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eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans

21 January 2018

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mTOR is a key modulator of ageing and age-related disease

21 January 2018

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Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.

21 January 2018

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A Drosophila Minute gene encodes a ribosomal protein.

21 January 2018

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Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish

21 January 2018

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Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute

21 January 2018

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Diagnosing and treating Diamond Blackfan anaemia: results of an international clinical consensus conference

21 January 2018

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Many ribosomal protein genes are cancer genes in zebrafish

21 January 2018

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Mitonuclear protein imbalance as a conserved longevity mechanism

21 January 2018

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c-Myc target genes involved in cell growth, apoptosis, and metabolism

21 January 2018

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MYC on the path to cancer

21 January 2018

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Evolution of the holozoan ribosome biogenesis regulon

21 January 2018

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Reduced expression of MYC increases longevity and enhances healthspan

21 January 2018

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The transcription factor Ifh1 is a key regulator of yeast ribosomal protein genes.

21 January 2018

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Integration of multiple nutrient cues and regulation of lifespan by ribosomal transcription factor Ifh1

21 January 2018

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H/ACA small RNA dysfunctions in disease reveal key roles for noncoding RNA modifications in hematopoietic stem cell differentiation.

21 January 2018

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A comparative study of nucleostemin family members in zebrafish reveals specific roles in ribosome biogenesis

21 January 2018

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The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively

21 January 2018

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TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients

21 January 2018

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Nucleolar GTPase NOG-1 regulates development, fat storage, and longevity through insulin/IGF signaling in C. elegans

21 January 2018

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Nucleolar proteins suppress Caenorhabditis elegans innate immunity by inhibiting p53/CEP-1

21 January 2018

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Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively

21 January 2018

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A cluster of methylations in the domain IV of 25S rRNA is required for ribosome stability.

21 January 2018

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Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.

21 January 2018

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Bacterial Nitric Oxide Extends the Lifespan of C. elegans

21 January 2018

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A Long Noncoding RNA on the Ribosome Is Required for Lifespan Extension

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

1 reference