Longevity, aging and rapamycin (Q34396541)

1 August 2017

5 references

20 August 2019

28 September 2019

11 November 2019

24 July 2020

28 January 2021

Longevity, aging and rapamycin (English)

1 reference

Serine/threonine-protein kinase TOR

1 August 2017

physiological phenomenon

1 reference

20 August 2019

1 reference

28 September 2019

1 reference

11 November 2019

1 reference

24 July 2020

1 reference

28 January 2021

Dan Ehninger

1

1 reference

PubMed ID

25015322

1 August 2017

Frauke Neff

series ordinal

2

1 reference

PubMed ID

25015322

1 August 2017

Kan Xie

series ordinal

3

1 reference

1 August 2017

1 November 2014

6 references

Cellular and Molecular Life Sciences

1 August 2017

20 August 2019

28 September 2019

11 November 2019

24 July 2020

28 January 2021

6 references

1 August 2017

20 August 2019

28 September 2019

11 November 2019

24 July 2020

28 January 2021

71

1 reference

1 August 2017

4325-4346

1 reference

1 August 2017

22

1 reference

Creative Commons Attribution 4.0 International

1 August 2017

start time

12 July 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1007/s00018-014-1677-1

0 references

cites work

Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

eRapa restores a normal life span in a FAP mouse model.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Rapamycin extends murine lifespan but has limited effects on aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Late-life rapamycin treatment reverses age-related heart dysfunction.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Rapamycin extends life and health in C57BL/6 mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Rapalogs in cancer prevention: anti-aging or anticancer?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Practical pathology of aging mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

From genes to cognition in tuberous sclerosis: implications for mTOR inhibitor-based treatment approaches

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Rapamycin slows aging in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Pathobiology of aging mice and GEM: background strains and experimental design

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Age sensitivity of behavioral tests and brain substrates of normal aging in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Cardiac aging in mice and humans: the role of mitochondrial oxidative stress

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Translational regulatory mechanisms in synaptic plasticity and memory storage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Rapamycin extends maximal lifespan in cancer-prone mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of rapamycin-dependent endometrial hyperplasia and carcinoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

An emerging role of mTOR in lipid biosynthesis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

A complex interplay between Akt, TSC2 and the two mTOR complexes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Regulation of pancreas plasticity and malignant transformation by Akt signaling.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

A role for autophagy in the extension of lifespan by dietary restriction in C. elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

The mammalian target of rapamycin pathway as a potential target for cancer chemoprevention

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

An anti-aging drug today: from senescence-promoting genes to anti-aging pill

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

The NF1 tumor suppressor critically regulates TSC2 and mTOR.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Biochemical mechanisms for translational regulation in synaptic plasticity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Mammalian target of rapamycin inhibition as therapy for hematologic malignancies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Genetics: influence of TOR kinase on lifespan in C. elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

TSC2 mediates cellular energy response to control cell growth and survival

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Experience-induced neurogenesis in the senescent dentate gyrus.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Longevity, body weight, and neoplasia in ad libitum-fed and diet-restricted C57BL6 mice fed NIH-31 open formula diet

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Gerontological data of C57BL/6J mice. II. Changes in blood cell counts in the course of natural aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207939

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

6 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1677-1

Biomedicine. A putative antiaging drug takes a step from mice to men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1677-1

eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1677-1

The pharmacology of mTOR inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1677-1

Rapamycin's resurrection: a new way to target the cancer cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1677-1

Influence of diet restriction on NMDA receptor subunits and learning during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1677-1

Investigation of age-related cognitive decline using mice as a model system: behavioral correlates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1677-1

Toward the behavioral assessment of biological aging in the laboratory mouse: concepts, terminology, and objectives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1677-1

Changes in bone structure and mass with advancing age in the male C57BL/6J mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1677-1

mTOR inhibition and erythropoiesis: microcytosis or anaemia?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1677-1

The effect of fasting and refeeding on thyroid follicule structure and thyroid hormone levels in young and old rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1677-1

Genetic loci that influence cause of death in a heterogeneous mouse stock

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25015322

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Distribution of sirolimus in rat tissue

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25015322

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hematologic and clinical chemistry findings in control BALB/c and C57BL/6 mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25015322

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00018-014-1677-1

1 reference

1 August 2017

1 reference

1 August 2017

1 reference

PubMed ID

25015322