Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus (Q26775893)

Clinical Interventions in Aging

27 January 2021

insulin-secreting cells

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27 January 2021

2

Seong Soo A An

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author name string

Hye Rin Jeong

series ordinal

1

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language of work or name

English

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publication date

19 November 2015

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4 February 2021

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10

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page(s)

1873-9

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copyright license

Creative Commons Attribution-NonCommercial

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on focus list of Wikimedia project

ScienceSource

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cites work

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A mechanistic approach for islet amyloid polypeptide aggregation to develop anti-amyloidogenic agents for type-2 diabetes

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Combination of kinetically selected inhibitors in trans leads to highly effective inhibition of amyloid formation

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High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

28 September 2017

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Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death

28 September 2017

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28 September 2017

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Copper, oxidative stress, and human health

28 September 2017

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Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells

28 September 2017

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Contribution of the intrinsic disulfide to the assembly mechanism of islet amyloid

28 September 2017

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Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?

28 September 2017

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S20G mutant amylin exhibits increased in vitro amyloidogenicity and increased intracellular cytotoxicity compared to wild-type amylin

28 September 2017

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Missense mutation of amylin gene (S20G) in Japanese NIDDM patients

28 September 2017

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28 September 2017

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Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited.

28 September 2017

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28 September 2017

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Deamidation accelerates amyloid formation and alters amylin fiber structure

28 September 2017

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Role of zinc in human islet amyloid polypeptide aggregation.

31 May 2018

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Deamidation destabilizes and triggers aggregation of a lens protein, betaA3-crystallin.

31 May 2018

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Chemical modification of insulin in amyloid fibrils

31 May 2018

1 reference

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The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

31 May 2018

1 reference

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Interaction of antimicrobial dermaseptin and its fluorescently labeled analogues with phospholipid membranes

31 May 2018

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pH dependence of amylin fibrillization.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

Molecular simulations indicate marked differences in the structure of amylin mutants, correlated with known aggregation propensity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

Role of aromatic interactions in amyloid formation by islet amyloid polypeptide

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

Effect of the disulfide bond on the monomeric structure of human amylin studied by combined Hamiltonian and temperature replica exchange molecular dynamics simulations

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

Alanine-2 carbonyl is an oxygen ligand in Cu2+ coordination of Alzheimer's disease amyloid-beta peptide--relevance to N-terminally truncated forms.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

Role of copper ion in the pathogenesis of type 2 diabetes.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

Islet amyloid polypeptide forms rigid lipid-protein amyloid fibrils on supported phospholipid bilayers

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

Copper(II) inhibits the formation of amylin amyloid in vitro

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

Copper-mediated formation of hydrogen peroxide from the amylin peptide: A novel mechanism for degeneration of islet cells in type-2 diabetes mellitus?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

Amylin in the periphery II: An updated mini-review.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

The role of His-18 in amyloid formation by human islet amyloid polypeptide

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

Lipid membranes modulate the structure of islet amyloid polypeptide.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

Gastric emptying is accelerated in diabetic BB rats and is slowed by subcutaneous injections of amylin

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655906

Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide

28 November 2018

1 reference

12 December 2020

Pore formation by the cytotoxic islet amyloid peptide amylin

1 reference

12 December 2020

Heparin-binding properties of the amyloidogenic peptides Abeta and amylin. Dependence on aggregation state and inhibition by Congo red

1 reference

12 December 2020

Aromatic Interactions Are Not Required for Amyloid Fibril Formation by Islet Amyloid Polypeptide but Do Influence the Rate of Fibril Formation and Fibril Morphology†

1 reference

12 December 2020

A Single-Point Mutation Converts the Highly Amyloidogenic Human Islet Amyloid Polypeptide into a Potent Fibrillization Inhibitor

1 reference

12 December 2020

Amyloid Fibril Formation from Full-Length and Fragments of Amylin

1 reference

12 December 2020