Type 2 diabetes and the aging pancreatic beta cell (Q35188218)

7 August 2017

10 references

13 March 2019

14 March 2019

24 March 2019

5 August 2019

20 August 2019

7 October 2019

10 October 2019

12 October 2019

27 January 2021

4 February 2021

Type 2 diabetes and the aging pancreatic beta cell (English)

1 reference

7 August 2017

6 references

5 August 2019

20 August 2019

7 October 2019

10 October 2019

12 October 2019

4 February 2021

1 reference

5 August 2019

physiological phenomenon

1 reference

20 August 2019

human digestive system

1 reference

7 October 2019

1 reference

10 October 2019

1 reference

12 October 2019

insulin-secreting cells

1 reference

27 January 2021

Uma Gunasekaran

1

1 reference

PubMed ID

21765202

7 August 2017

Maureen Gannon

series ordinal

2

1 reference

PubMed ID

21765202

7 August 2017

language of work or name

1 reference

1 June 2011

11 references

7 August 2017

13 March 2019

14 March 2019

24 March 2019

5 August 2019

20 August 2019

7 October 2019

10 October 2019

12 October 2019

27 January 2021

4 February 2021

11 references

7 August 2017

13 March 2019

14 March 2019

24 March 2019

5 August 2019

20 August 2019

7 October 2019

10 October 2019

12 October 2019

27 January 2021

4 February 2021

3

1 reference

7 August 2017

6

1 reference

7 August 2017

565-575

1 reference

Creative Commons Attribution 2.5 Generic

7 August 2017

10 references

13 March 2019

14 March 2019

24 March 2019

5 August 2019

20 August 2019

7 October 2019

10 October 2019

12 October 2019

27 January 2021

on focus list of Wikimedia project

4 February 2021

ScienceSource

0 references

cites work

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Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating

13 July 2018

1 reference

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Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

13 July 2018

1 reference

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Regulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes

13 July 2018

1 reference

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Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3.

13 July 2018

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Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen

13 July 2018

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beta-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice

13 July 2018

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Cyclin D2 protein stability is regulated in pancreatic beta-cells

13 July 2018

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Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

13 July 2018

1 reference

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Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation

13 July 2018

1 reference

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Adaptive beta-cell proliferation is severely restricted with advanced age.

13 July 2018

1 reference

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Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice

13 July 2018

1 reference

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Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006

13 July 2018

1 reference

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Beta-cell proliferation, but not neogenesis, following 60% partial pancreatectomy is impaired in the absence of FoxM1.

13 July 2018

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Malignant melanoma in the 21st century: the emerging molecular landscape

13 July 2018

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pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis

13 July 2018

1 reference

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Roles and regulation of transcription factor MafA in islet beta-cells

13 July 2018

1 reference

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Effect of aging on insulin secretory function and expression of beta cell function-related genes of islets

13 July 2018

1 reference

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Epigenetic signatures of stem-cell identity.

13 July 2018

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p16INK4a induces an age-dependent decline in islet regenerative potential

13 July 2018

1 reference

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Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1

13 July 2018

1 reference

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Molecular control of cell cycle progression in the pancreatic beta-cell

13 July 2018

1 reference

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Diabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion?

13 July 2018

1 reference

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FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

MafA is a key regulator of glucose-stimulated insulin secretion

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Melanoma genetics and the development of rational therapeutics

13 July 2018

1 reference

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Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells

13 July 2018

1 reference

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Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

13 July 2018

1 reference

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Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor

13 July 2018

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Bmi1, stem cells, and senescence regulation

13 July 2018

1 reference

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Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number

13 July 2018

1 reference

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

13 July 2018

1 reference

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The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration

13 July 2018

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A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1

13 July 2018

1 reference

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Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity

13 July 2018

1 reference

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Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

13 July 2018

1 reference

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The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Independent influence of age on basal insulin secretion in nondiabetic humans. European Group for the Study of Insulin Resistance

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Reconstitution of glucotoxic HIT-T15 cells with somatostatin transcription factor-1 partially restores insulin promoter activity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Oxidative stress, caloric restriction, and aging

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased beta-cell function.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Morphological changes in the endocrine pancreas in pregnant rats with experimental diabetes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

A morphological study of the endocrine pancreas in human pregnancy

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Impaired islet turnover in human donor pancreata with aging.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Tissue-specific deletion of the retinoblastoma protein in the pancreatic beta-cell has limited effects on beta-cell replication, mass, and function.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

The cell cycle inhibitory protein p21cip is not essential for maintaining beta-cell cycle arrest or beta-cell function in vivo.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Prevalence of diabetes and impaired fasting glucose in adults in the U.S. population: National Health And Nutrition Examination Survey 1999-2002.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Very slow turnover of beta-cells in aged adult mice

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Overexpression of cyclin D1 in pancreatic beta-cells in vivo results in islet hyperplasia without hypoglycemia.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Effects of sequential proline substitutions on amyloid formation by human amylin20-29.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3164365

Evaluation of beta-cell replication in mice transgenic for hepatocyte growth factor and placental lactogen: comprehensive characterization of the G1/S regulatory proteins reveals unique involvement of p21cip

27 September 2018

1 reference

12 December 2020

Beta cell adaptation in pregnancy: a major difference between humans and rodents?

1 reference

12 December 2020

Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity

1 reference

12 December 2020

Beta cell function declines with age in glucose tolerant Caucasians

1 reference

12 December 2020

Growth hormone stimulates proliferation of old-aged regenerating liver through forkhead box m1b

1 reference

12 December 2020

Quantitative studies on amyloid in the islets of Langerhans

1 reference

12 December 2020

[Amyloid of islets of Langerhans and its relation to diabetes mellitus (author's transl)]

1 reference

12 December 2020

The diabetogenic effects of streptozotocin in mice are prolonged and inversely related to age

1 reference

12 December 2020

The effect of glucose on insulin release and ion movements in isolated pancreatic islets of rats in old age

1 reference

12 December 2020

Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells

1 reference

12 December 2020

Relationship between glucose tolerance and glucose-stimulated insulin response in 65-year-olds

1 reference

12 December 2020

Cooperative tumorigenic effects of germline mutations in Rb and p53

1 reference

12 December 2020

Regulatory factor linked to late-onset diabetes?

1 reference

12 December 2020

Identifiers

DOI

10.18632/AGING.100350

0 references

PMCID

3164365

1 reference

7 August 2017

1 reference

PubMed ID

21765202