Timing of therapies for Down syndrome: the sooner, the better (Q26779297)

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Sandra Guidi

object named as

Sandra Guidi

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Elisabetta Ciani

object named as

Elisabetta Ciani

4

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author name string

Renata Bartesaghi

Frontiers in Behavioral Neuroscience

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language of work or name

English

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publication date

2015

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published in

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volume

9

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page(s)

265

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cites work

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Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome

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Prenatal treatment of Down syndrome: a reality?

28 September 2017

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Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice.

28 September 2017

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Size does not always matter: Ts65Dn Down syndrome mice show cerebellum-dependent motor learning deficits that cannot be rescued by postnatal SAG treatment

28 September 2017

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Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model

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Formoterol, a long-acting β2 adrenergic agonist, improves cognitive function and promotes dendritic complexity in a mouse model of Down syndrome

28 September 2017

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The effects of maternal depression and maternal selective serotonin reuptake inhibitor exposure on offspring

28 September 2017

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Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome

28 September 2017

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Noninvasive prenatal testing creates an opportunity for antenatal treatment of Down syndrome

28 September 2017

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Short-term treatment with the GABAA receptor antagonist pentylenetetrazole produces a sustained pro-cognitive benefit in a mouse model of Down's syndrome

28 September 2017

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Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome.

28 September 2017

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28 September 2017

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Prenatal treatment prevents learning deficit in Down syndrome model

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Lithium rescues synaptic plasticity and memory in Down syndrome mice

28 September 2017

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Adult-onset fluoxetine treatment does not improve behavioral impairments and may have adverse effects on the Ts65Dn mouse model of Down syndrome

28 September 2017

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Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists.

28 September 2017

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28 September 2017

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Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome

28 September 2017

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Is it possible to improve neurodevelopmental abnormalities in Down syndrome?

28 September 2017

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Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer

28 September 2017

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Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model

28 September 2017

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Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of Down syndrome

28 September 2017

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Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

28 September 2017

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Hepatotoxicity of high oral dose (-)-epigallocatechin-3-gallate in mice

28 September 2017

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Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.

28 September 2017

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Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.

28 September 2017

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NAP and D-SAL: neuroprotection against the beta amyloid peptide (1-42)

28 September 2017

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Prevention of developmental delays in a Down syndrome mouse model

28 September 2017

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Cerebellum morphogenesis: the foliation pattern is orchestrated by multi-cellular anchoring centers

28 September 2017

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Mental retardation and associated neurological dysfunctions in Down syndrome: a consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways

28 September 2017

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28 September 2017

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Morphology, molecular codes, and circuitry produce the three-dimensional complexity of the cerebellum

28 September 2017

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28 September 2017

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Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn.

28 September 2017

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Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice

28 September 2017

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Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome.

28 September 2017

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28 September 2017

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On dendrites in Down syndrome and DS murine models: a spiny way to learn.

28 September 2017

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Development and developmental disorders of the human cerebellum

28 September 2017

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Serotonin and brain development: role in human developmental diseases

28 September 2017

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28 September 2017

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Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods

28 September 2017

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Mosaic organization of the hippocampal neuroepithelium and the multiple germinal sources of dentate granule cells

28 September 2017

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Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome

28 September 2017

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Growth and development of the brain in Down syndrome

28 September 2017

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α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594009

Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.

31 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594009

Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594009

Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594009

Cell formation in the cortical layers of the developing human cerebellum.

31 May 2018

1 reference

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Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down syndrome

21 January 2018

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https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.

21 January 2018

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https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Lithium restores neurogenesis in the subventricular zone of the Ts65Dn mouse, a model for Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Rescue of synaptic failure and alleviation of learning and memory impairments in a trisomic mouse model of down syndrome.

21 January 2018

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https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Chronic melatonin treatment rescues electrophysiological and neuromorphological deficits in a mouse model of Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Down syndrome: the brain in trisomic mode.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Synaptogenesis in the postnatal rat fascia dentata is influenced by 5-HT1a receptor activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Early pharmacotherapy with fluoxetine rescues dendritic pathology in the Ts65Dn mouse model of down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

A placebo controlled crossover trial of liquid fluoxetine on repetitive behaviors in childhood and adolescent autism

21 January 2018

1 reference

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Minocycline prevents cholinergic loss in a mouse model of Down's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Prevention of learning deficit in a Down syndrome model.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Safety studies on epigallocatechin gallate (EGCG) preparations. Part 3: teratogenicity and reproductive toxicity studies in rats

21 January 2018

1 reference

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The effects of piracetam on cognitive performance in a mouse model of Down's syndrome

21 January 2018

1 reference

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Fetal exposure to antidepressants and normal milestone development at 6 and 19 months of age.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Cell formation in the human hippocampal formation from mid-gestation to the late postnatal period

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Long-term effects of neonatal treatment with fluoxetine on cognitive performance in Ts65Dn mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Green tea EGCG plus fish oil omega-3 dietary supplements rescue mitochondrial dysfunctions and are safe in a Down's syndrome child.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Prenatal NAP+SAL prevents developmental delay in a mouse model of Down syndrome through effects on N-methyl-D-aspartic acid and gamma-aminobutyric acid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Promotion of neuronal plasticity by (-)-epigallocatechin-3-gallate

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Early oxidative stress in amniotic fluid of pregnancies with Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNBEH.2015.00265

Incidence of major malformations in infants following antidepressant exposure in pregnancy: results of a large prospective cohort study

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594009

Selective serotonin reuptake inhibitors in pregnant women and neonatal withdrawal syndrome: a database analysis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594009

Fluoxetine response in children with autistic spectrum disorders: correlation with familial major affective disorder and intellectual achievement

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594009

[Open study of fluoxetine in children with autism]

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594009

Dendrites, dementia and the Down syndrome.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594009

Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26500515

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3389/FNBEH.2015.00265

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4075942

Fatcat ID

release_hjjmnus7czhi5j2slf7mrie73e

0 references

OpenCitations bibliographic resource ID

4075942

1 reference