Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities (Q26863005)

Jesús Flórez

series ordinal

2

1 reference

Carmen Martínez-Cué

series ordinal

3

1 reference

language of work or name

1 reference

2012

1 reference

22 May 2012

6 references

22 April 2019

25 April 2019

20 June 2019

19 September 2019

6 July 2020

3 December 2020

7 references

22 April 2019

25 April 2019

20 June 2019

19 September 2019

6 July 2020

3 December 2020

2012

1 reference

page(s)

584071

1 reference

Creative Commons Attribution 3.0 Unported

copyright license

6 references

22 April 2019

25 April 2019

20 June 2019

19 September 2019

6 July 2020

on focus list of Wikimedia project

3 December 2020

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

Down syndrome: searching for the genetic culprits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Supplementation with antioxidants and folinic acid for children with Down's syndrome: randomised controlled trial

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Neurogenesis may relate to some but not all types of hippocampal-dependent learning

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Nerve growth factor signaling, neuroprotection, and neural repair

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Structure-stability-function relationships of dendritic spines

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

A distinct role for norepinephrine in memory retrieval

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Running enhances neurogenesis, learning, and long-term potentiation in mice

21 March 2017

2 references

https://api.crossref.org/works/10.1155/2012/584071

22 April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Place navigation impaired in rats with hippocampal lesions

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Functional neurogenesis in the adult hippocampus

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

More hippocampal neurons in adult mice living in an enriched environment

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

GABA regulates synaptic integration of newly generated neurons in the adult brain

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

The specificities of protein kinase inhibitors: an update

7 April 2017

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Positron emission tomography and neuropathologic estimates of fibrillar amyloid-β in a patient with Down syndrome and Alzheimer disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Neurobiological elements of cognitive dysfunction in down syndrome: exploring the role of APP.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Environmental enrichment rescues postnatal neurogenesis defect in the male and female Ts65Dn mouse model of Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Behavioral flexibility in a mouse model of developmental cerebellar Purkinje cell loss

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Effect of leucovorin (folinic acid) on the developmental quotient of children with Down's syndrome (trisomy 21) and influence of thyroid status

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

A critical period in cortical interneuron neurogenesis in down syndrome revealed by human neural progenitor cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

The complex relationship between folate/homocysteine metabolism and risk of Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Normal protein composition of synapses in Ts65Dn mice: a mouse model of Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Spine microdomains for postsynaptic signaling and plasticity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

NAP and D-SAL: neuroprotection against the beta amyloid peptide (1-42)

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Prevention of developmental delays in a Down syndrome mouse model

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Genotype-phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Minocycline and neurodegenerative diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

RO4938581, a novel cognitive enhancer acting at GABAA alpha5 subunit-containing receptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Neurogenesis and exercise: past and future directions.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Animal models of anxiety in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Genomic and functional profiling of human Down syndrome neural progenitors implicates S100B and aquaporin 4 in cell injury.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Episodic-like memory in Ts65Dn, a mouse model of Down syndrome.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

The place of choline acetyltransferase activity measurement in the "cholinergic hypothesis" of neurodegenerative diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Fluoxetine targets early progenitor cells in the adult brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

NAP: research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Motor development and neuropsychological patterns in persons with Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Neuroanatomy of Down syndrome in vivo: a model of preclinical Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Neurotrophin signalling in health and disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Piracetam: a review of pharmacological properties and clinical uses.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Segmental trisomy of chromosome 17: a mouse model of human aneuploidy syndromes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Designing mouse behavioral tasks relevant to autistic-like behaviors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Impaired sustained attention and error-induced stereotypy in the aged Ts65Dn mouse: a mouse model of Down syndrome and Alzheimer's disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

A chromosome 21 critical region does not cause specific Down syndrome phenotypes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Retrograde transport of neurotrophins: fact and function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Down's syndrome: a genetic disorder in biobehavioral perspective

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Systematic review of the effect of therapeutic dietary supplements and drugs on cognitive function in subjects with Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Fetal life in Down syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Unaltered expression of Fas (CD95/APO-1), caspase-3, Bcl-2 and annexins in brains of fetal Down syndrome: evidence against increased apoptosis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Serotonin and brain development: role in human developmental diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Regulation of adult neurogenesis by antidepressant treatment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Psychotogenic properties of benzodiazepine receptor inverse agonists

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Behavioral phenotype of individuals with Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Cognitive functions of the basal forebrain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

The growth of non-pyramidal neurons in the primary motor cortex of man: a Golgi study.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Segmental trisomy as a mouse model for Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Development of the superior temporal neocortex is anomalous in trisomy 21.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Benzodiazepine impairs and beta-carboline enhances performance in learning and memory tasks

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Effects of benzodiazepines on acquisition and performance: a critical assessment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

The neurobiologic consequences of Down syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

The amnesic action of benzodiazepines in man.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Alzheimer-like neurotransmitter deficits in adult Down's syndrome brain tissue

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Benzodiazepines and human memory: a review.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Pyramidal cell abnormalities in the motor cortex of a child with Down's syndrome. A Golgi study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Amplified developmental instability in Down's syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Hippocampal hypocellularity in the Ts65Dn mouse originates early in development

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Behavioral comparison of 4 and 6 month-old Ts65Dn mice: age-related impairments in working and reference memory

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Environmental stimulation of 129/SvJ mice causes increased cell proliferation and neurogenesis in the adult dentate gyrus

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Aberrant expression of bcl-2 gene family in Down's syndrome brains.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Reduced inferior olivary neuron number in early Down syndrome.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Long-term memory in mental retardation: evidence for a specific impairment in subjects with Down's syndrome.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Impaired cyclic AMP production in the hippocampus of a Down syndrome murine model.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Behavioral assessment of the Ts65Dn mouse, a model for Down syndrome: altered behavior in the elevated plus maze and open field

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Dendritic and histochemical development and ageing in patients with Down's syndrome

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Molecular mapping of twenty-four features of Down syndrome on chromosome 21.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

A mouse model for Down syndrome exhibits learning and behaviour deficits.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Abnormal neuronal development in the visual cortex of the human fetus and infant with down's syndrome. A quantitative and qualitative Golgi study.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Pathology of the auditory system in autosomal trisomies with morphometric and quantitative study of the ventral cochlear nucleus.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Spine distribution along the apical dendrites of the pyramidal neurons in Down's syndrome. A quantitative Golgi study.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Severe anxiety induced by FG 7142, a beta-carboline ligand for benzodiazepine receptors.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Effects of rearing complexity on dendritic branching in frontolateral and temporal cortex of the rat.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Dynamics of postural control in the child with Down syndrome

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Dendritic atrophy in children with Down's syndrome.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Regional brain 5-hydroxytryptamine levels are reduced in senile Down's syndrome as in Alzheimer's disease.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Down's syndrome and Alzheimer's disease: dendritic spine counts in the hippocampus.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Relation of EEG alpha background to cognitive function, brain atrophy, and cerebral metabolism in Down's syndrome. Age-specific changes.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Kinematic and electromyographic characteristics of single-joint movements of individuals with Down syndrome

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Fetal human brain exhibits a prenatal peak in the density of serotonin 5-HT1A receptors

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Brief exposure to an enriched environment improves performance on the Morris water task and increases hippocampal cytosolic protein kinase C activity in young rats

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Neurohistological findings in the parietal cortex of children with chromosome aberrations

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Comparative coherence studies in healthy volunteers and Down's syndrome patients from childhood to adult age

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Systematic approach to the study of trisomy in the mouse. II

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Prevalence of Down syndrome among children and adolescents in 10 regions of the United States

31 May 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

A behavioral assessment of Ts65Dn mice: a putative Down syndrome model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Motor dysfunction in a mouse model for Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Chronobiometry of behavioral activity in the Ts65Dn model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Anxiety and panic responses to a predator in male and female Ts65Dn mice, a model for Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Spatial memory deficits in segmental trisomic Ts65Dn mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Operant conditioning in the Ts65Dn mouse: learning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Cerebral morphologic distinctions between Williams and Down syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Neuroanatomy of Down's syndrome: a high-resolution MRI study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Magnetic resonance imaging analysis of age-related changes in the brains of individuals with Down's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Cerebellar volume in adults with Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Amygdala and hippocampal volumes in children with Down syndrome: a high-resolution MRI study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Relation of corpus callosum and hippocampal size to age in nondemented adults with Down's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Ibotenate Lesions of Hippocampus and/or Subiculum: Dissociating Components of Allocentric Spatial Learning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Effects of voluntary physical exercise on adult hippocampal neurogenesis and behavior of Ts65Dn mice, a model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Reduced cell number in the neocortical part of the human fetal brain in Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Excitatory amino acids and monoamines in parahippocampal gyrus and frontal cortical pole of adults with Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Minocycline prevents cholinergic loss in a mouse model of Down's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Lithium restores neurogenesis in the subventricular zone of the Ts65Dn mouse, a model for Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Increased lipid peroxidation in Down's syndrome mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Expression patterns and subcellular localization of the Down syndrome candidate protein MNB/DYRK1A suggest a role in late neuronal differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Discovery of novel hippocampal neurogenic agents by using an in vivo stable isotope labeling technique.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

The Ts65Dn mouse model of Down syndrome shows reduced expression of the Bcl-X(L) antiapoptotic protein in the hippocampus not accompanied by changes in molecular or cellular markers of cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Perinatal growth of prefrontal layer III pyramids in Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

From the behavioral pharmacology of beta-carbolines to seizures, anxiety, and memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Fetal Down syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Cholinergic, serotonergic and catecholaminergic neurons are not affected in Ts65Dn mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Brain G protein-dependent signaling pathways in Down syndrome and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Stimulated neuronal expression of brain-derived neurotrophic factor by Neurotropin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Rescue of synaptic failure and alleviation of learning and memory impairments in a trisomic mouse model of down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Promotion of neuronal plasticity by (-)-epigallocatechin-3-gallate

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Relation of medial temporal lobe volumes to age and memory function in nondemented adults with Down's syndrome: implications for the prodromal phase of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Prevention of learning deficit in a Down syndrome model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

The potential of hematopoietic growth factors for treatment of Alzheimer's disease: a mini-review

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Evidence for increased mitochondrial superoxide production in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Biomarkers of oxidative stress are significantly elevated in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Neuroendocrine-specific protein C, a marker of neuronal differentiation, is reduced in brain of patients with Down syndrome and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

GVS-111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Donepezil effects on language in children with Down syndrome: results of the first 22-week pilot clinical trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

The efficacy, safety, and tolerability of donepezil for the treatment of young adults with Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Piracetam therapy does not enhance cognitive functioning in children with down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

The effects of piracetam on cognitive performance in a mouse model of Down's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F584071

Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Prenatal NAP+SAL prevents developmental delay in a mouse model of Down syndrome through effects on N-methyl-D-aspartic acid and gamma-aminobutyric acid receptors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Effects of exercise on neurogenesis in the dentate gyrus and ability of learning and memory after hippocampus lesion in adult rats.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Memory development and intellectual disabilities.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

EFFECT OF NEONATAL CORTICAL LESIONS AND EARLY ENVIRONMENTAL FACTORS ON ADULT RAT BEHAVIOR.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Alteration of caspases and other apoptosis regulatory proteins in Down syndrome

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

MRI volumes of the hippocampus and amygdala in adults with Down's syndrome with and without dementia.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Cellular and molecular basis of estrogen's neuroprotection. Potential relevance for Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Learning and memory in the autoimmune BXSB mouse: effects of neocortical ectopias and environmental enrichment.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

A comparison of the contributions of the frontal and parietal association cortex to spatial localization in rats.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Evidence of arrest of neurogenesis and synaptogenesis in brains of patients with Down's syndrome.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Dendrites, dementia and the Down syndrome.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Pathological evidence for neurotransmitter deficits in Down's syndrome of middle age.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3364589

Biometry of face and brain in fetuses with trisomy 21

28 November 2018

1 reference

12 December 2020

Analysis of "invariant characteristics" in the motor control of down's syndrome and normal subjects

1 reference

12 December 2020

Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation

1 reference

12 December 2020

Cerebellar and frontal lobe hypoplasia in fetuses with trisomy 21: usefulness as combined US markers

1 reference

12 December 2020

Selective neuroanatomic abnormalities in Down's syndrome and their cognitive correlates: evidence from MRI morphometry.

1 reference

12 December 2020

Donepezil for treatment of cognitive dysfunction in children with Down syndrome aged 10-17

1 reference

12 December 2020

Donepezil for the treatment of language deficits in adults with Down syndrome: a preliminary 24-week open trial

1 reference

12 December 2020

Differential effects of trisomy on brain shape and volume in related aneuploid mouse models

1 reference

12 December 2020

Mechanism of the analgesic effect of neurotropin

1 reference

12 December 2020

Identifiers

DOI

10.1155/2012/584071

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4248313

OpenCitations bibliographic resource ID

4248313

1 reference