Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins (Q26849720)

Nadège Carré

series ordinal

2

1 reference

Anne-Françoise Burnol

series ordinal

3

1 reference

language of work or name

1 reference

February 2013

1 reference

1 reference

280

1 reference

PubMed

page(s)

794-816

1 reference

PubMed

issue

3

1 reference

The twentieth century struggle to decipher insulin signalling

PubMed

cites work

1 reference

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Critical nodes in signalling pathways: insights into insulin action

21 January 2018

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Regulation of insulin receptor function

21 January 2018

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Grb10: more than a simple adaptor protein

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.12080

Grb10 exceeding the boundaries of a common signaling adapter.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.12080

Regulation and functional roles of Grb14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Grb10 and Grb14: enigmatic regulators of insulin action--and more?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Grb7 in intracellular signaling and its role in cell regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

SH2B1 (SH2-B) and JAK2: a multifunctional adaptor protein and kinase made for each other

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Interaction between the insulin receptor and Grb14: a dynamic study in living cells using BRET.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

A phenylalanine zipper mediates APS dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Kinase activation through dimerization by human SH2-B

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

The PIR domain of Grb14 is an intrinsically unstructured protein: implication in insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Association of Grb7 with phosphoinositides and its role in the regulation of cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Lipid-protein interactions of growth factor receptor-bound protein 14 in insulin receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Grb14 inhibits FGF receptor signaling through the regulation of PLCγ recruitment and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Tyrosine phosphorylation of Grb14 by Tie2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Inhibition of FGF receptor signalling in Xenopus oocytes: differential effect of Grb7, Grb10 and Grb14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

The insulin resistance Grb14 adaptor protein promotes thyroid cancer ret signaling and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Identification of the rat adapter Grb14 as an inhibitor of insulin actions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

The yeast tribrid system--genetic detection of trans-phosphorylated ITAM-SH2-interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

SH2-B is required for both male and female reproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

PSM, an insulin-dependent, pro-rich, PH, SH2 domain containing partner of the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Adaptor protein SH2-B linking receptor-tyrosine kinase and Akt promotes adipocyte differentiation by regulating peroxisome proliferator-activated receptor gamma messenger ribonucleic acid levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Identification of the APS protein as a novel insulin receptor substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Compartmentalization and in vivo insulin-induced translocation of the insulin-signaling inhibitor Grb14 in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

An imprinted gene network that controls mammalian somatic growth is down-regulated during postnatal growth deceleration in multiple organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Nedd4 controls animal growth by regulating IGF-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

The SH2B gene is associated with serum leptin and body fat in normal female twins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Large, rare chromosomal deletions associated with severe early-onset obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Genomic organization and control of the grb7 gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Cloning and characterization of GRB14, a novel member of the GRB7 gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Immunity to growth factor receptor-bound protein 10, a signal transduction molecule, inhibits the growth of breast cancer in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Hepatocyte nuclear factor (HNF)-4alpha-driven epigenetic silencing of the human PED gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Neuronal SH2B1 is essential for controlling energy and glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Contrasting effects of insulin and cellular differentiation on expression of the novel insulin receptor substrate APS in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Inhibition of hGrb10 binding to the insulin receptor by functional domain-mediated oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology [...]

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

The role of mGrb10alpha in insulin-like growth factor I-mediated growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Molecular determinants of Grb14-mediated inhibition of insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Negative regulation of insulin-stimulated mitogen-activated protein kinase signaling by Grb10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

The adapter protein GRB10 is an endogenous negative regulator of insulin-like growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Specific inhibition by hGRB10zeta of insulin-induced glycogen synthase activation: evidence for a novel signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Dual effect of the adapter growth factor receptor-bound protein 14 (grb14) on insulin action in primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Mitogenic roles of Gab1 and Grb10 as direct cellular partners in the regulation of MAP kinase signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Grb10 and active Raf-1 kinase promote Bad-dependent cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Grb10 interacts with Bim L and inhibits apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Meg1/Grb10 overexpression causes postnatal growth retardation and insulin resistance via negative modulation of the IGF1R and IR cascades.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Type 2 diabetes mellitus in a non-obese mouse model induced by Meg1/Grb10 overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Maternally-inherited Grb10 reduces placental size and efficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Protein tyrosine phosphatases: the quest for negative regulators of insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Insulin-like growth factor-I receptor and insulin receptor association with a Src homology-2 domain-containing putative adapter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Adapter protein with a pleckstrin homology (PH) and an Src homology 2 (SH2) domain (APS) and SH2-B enhance insulin-receptor autophosphorylation, extracellular-signal-regulated kinase and phosphoinositide 3-kinase-dependent signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Critical role of the Src homology 2 (SH2) domain of neuronal SH2B1 in the regulation of body weight and glucose homeostasis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Essential role of PSM/SH2-B variants in insulin receptor catalytic activation and the resulting cellular responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

PSM/SH2B1 splice variants: critical role in src catalytic activation and the resulting STAT3s-mediated mitogenic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

PSM/SH2-B distributes selected mitogenic receptor signals to distinct components in the PI3-kinase and MAP kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Insulin increase in MAP kinase phosphorylation is shifted to early time-points by overexpressing APS, while Akt phosphorylation is not influenced.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

CAP defines a second signalling pathway required for insulin-stimulated glucose transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

The interaction between the adaptor protein APS and Enigma is involved in actin organisation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Differential role of SH2-B and APS in regulating energy and glucose homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Role of insulin-like signalling in Drosophila lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

SH2B regulation of growth, metabolism, and longevity in both insects and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

mGrb10 interacts with Nedd4

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

The APS adapter protein couples the insulin receptor to the phosphorylation of c-Cbl and facilitates ligand-stimulated ubiquitination of the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

APS-mediated ubiquitination of the insulin receptor enhances its internalization, but does not induce its degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Grb10 regulates the development of fiber number in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

inferred from DOI database lookup

7 January 2021

based on heuristic

Increased adipose tissue expression of Grb14 in several models of insulin resistance

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080

inferred from DOI database lookup

7 January 2021

based on heuristic

Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12080