Guards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetes (Q26992217)

main subject

endoplasmic reticulum

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6 references

5 August 2019

7 October 2019

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18 November 2019

4 February 2021

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5 August 2019

human digestive system

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7 October 2019

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10 October 2019

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12 October 2019

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18 November 2019

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18 December 2020

insulin-secreting cells

1 reference

27 January 2021

Udayakumar Karunakaran

1

1 reference

Han-Jong Kim

2

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Joon-Young Kim

3

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In-Kyu Lee

4

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language of work or name

1 reference

2012

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Experimental Diabetes Research

1 October 2011

12 references

13 March 2019

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24 March 2019

5 August 2019

7 October 2019

10 October 2019

12 October 2019

18 November 2019

18 December 2020

27 January 2021

4 February 2021

19 July 2022

13 references

13 March 2019

14 March 2019

24 March 2019

5 August 2019

7 October 2019

10 October 2019

12 October 2019

18 November 2019

18 December 2020

27 January 2021

4 February 2021

19 July 2022

2012

1 reference

page(s)

639762

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Creative Commons Attribution 3.0 Unported

copyright license

12 references

13 March 2019

14 March 2019

24 March 2019

5 August 2019

7 October 2019

10 October 2019

12 October 2019

18 November 2019

18 December 2020

27 January 2021

4 February 2021

on focus list of Wikimedia project

19 July 2022

copyright status

copyrighted

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ScienceSource

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cites work

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Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis

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Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

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7 April 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.

28 September 2017

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Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload.

28 September 2017

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Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.

28 September 2017

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The changing shape of mitochondrial apoptosis

28 September 2017

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28 September 2017

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Long-term exposure to genistein improves insulin secretory function of pancreatic beta-cells

28 September 2017

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Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.

28 September 2017

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GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells

28 September 2017

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Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic beta-cell

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184438

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184438

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

28 September 2017

1 reference

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Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids

28 September 2017

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Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic beta-cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184438

The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis

28 September 2017

1 reference

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The role for endoplasmic reticulum stress in diabetes mellitus

28 September 2017

1 reference

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The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

28 September 2017

1 reference

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Involvement of Ca2+-mediated apoptotic signals in palmitate-induced MIN6N8a beta cell death

28 September 2017

1 reference

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High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

28 September 2017

1 reference

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Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians

28 September 2017

1 reference

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Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells

28 September 2017

1 reference

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Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184438

Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184438

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184438

Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184438

Islet beta cell failure in type 2 diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184438

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

28 September 2017

1 reference

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Genistein acutely stimulates insulin secretion in pancreatic beta-cells through a cAMP-dependent protein kinase pathway

28 September 2017

1 reference

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Cellular response to endoplasmic reticulum stress: a matter of life or death

28 September 2017

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Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

28 September 2017

1 reference

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ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity

28 September 2017

1 reference

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Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

28 September 2017

1 reference

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Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.

28 September 2017

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Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes

28 September 2017

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Palmitate-induced Ca2+-signaling in pancreatic beta-cells

28 September 2017

1 reference

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Glucagon-like peptide-1 and the islet beta-cell: augmentation of cell proliferation and inhibition of apoptosis

28 September 2017

1 reference

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Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

28 September 2017

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The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

28 September 2017

1 reference

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Visualizing superoxide production in normal and diabetic rat islets of Langerhans

28 September 2017

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Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.

28 September 2017

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Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

28 September 2017

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Pleiotropic effects of fatty acids on pancreatic beta-cells

28 September 2017

1 reference

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Translational control in the endoplasmic reticulum stress response

28 September 2017

1 reference

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Clinical importance of insulin secretion and its interaction with insulin resistance in the treatment of type 2 diabetes mellitus and its complications

28 September 2017

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Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis

28 September 2017

1 reference

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Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression

28 September 2017

1 reference

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Role of nitric oxide in obesity-induced beta cell disease

28 September 2017

1 reference

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Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice

28 September 2017

1 reference

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Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells

31 May 2018

1 reference

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Role for activating transcription factor 3 in stress-induced beta-cell apoptosis

31 May 2018

1 reference

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Endoplasmic reticulum Ca2+ is important for the proteolytic processing and intracellular transport of proinsulin in the pancreatic beta-cell

31 May 2018

1 reference

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Unbound free fatty acid levels in human serum.

31 May 2018

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Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells

31 May 2018

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Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

21 January 2018

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Involvement of endoplasmic reticulum stress in insulin resistance and diabetes

21 January 2018

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Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

21 January 2018

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Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians

21 January 2018

1 reference

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Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F639762

Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F639762

Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F639762

Standard energetics of phyllostomid bats: the inadequacies of phylogenetic-contrast analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F639762

Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184438

Antidiabetic effects of quercetin in streptozocin-induced diabetic rats

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184438

Coupling endoplasmic reticulum stress to cell death program in isolated human pancreatic islets: effects of gene transfer of Bcl-2.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184438

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3184438

Pathogenesis of type 2 diabetes mellitus

28 November 2018

1 reference

12 December 2020

Mitochondrial damages and the regulation of insulin secretion

1 reference

12 December 2020

Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin

1 reference

12 December 2020

Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2

1 reference

12 December 2020

Role of apoptosis in pancreatic beta-cell death in diabetes

1 reference

12 December 2020

release_lq7piakrx5cwtnp5m6g6yptlpy

Identifiers

1 reference

0 references

1 reference

PubMed publication ID

21977023

1 reference