Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family (Q27667527)

1

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Elizabeth A McSweeney

2

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Ravi R Iyer

3

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Michael A Hast

4

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Paul Modrich

6

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Lorena S Beese

Crystal structure of bacteriophage T4 5' nuclease in complex with a branched DNA reveals how flap endonuclease-1 family nucleases bind their substrates

7

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language of work or name

English

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publication date

15 April 2011

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published in

Cell

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volume

145

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issue

2

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page(s)

212-23

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cites work

1 reference

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Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA

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Molecular structure and novel DNA binding sites located in loops of flap endonuclease-1 from Pyrococcus horikoshii

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Molecular interactions of human Exo1 with DNA

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Human exonuclease I is required for 5' and 3' mismatch repair

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The interaction of DNA mismatch repair proteins with human exonuclease I

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The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities

20 March 2017

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Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli

20 March 2017

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Human exonuclease I interacts with the mismatch repair protein hMSH2

20 March 2017

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Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity

20 March 2017

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The crystal structure of flap endonuclease-1 from Methanococcus jannaschii

20 March 2017

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Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates

20 March 2017

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20 March 2017

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Structure of bacteriophage T4 RNase H, a 5' to 3' RNA-DNA and DNA-DNA exonuclease with sequence similarity to the RAD2 family of eukaryotic proteins

20 March 2017

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A helical arch allowing single-stranded DNA to thread through T5 5'-exonuclease

20 March 2017

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Essential amino acids for substrate binding and catalysis of human flap endonuclease 1

20 March 2017

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Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

20 March 2017

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20 March 2017

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MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes

20 March 2017

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20 March 2017

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20 March 2017

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Generation, representation and flow of phase information in structure determination: recent developments in and around SHARP 2.0

20 March 2017

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20 March 2017

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PHENIX: building new software for automated crystallographic structure determination

29 September 2017

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Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three-dimensional structure

20 March 2017

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Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

20 March 2017

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exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair

20 March 2017

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The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein

20 March 2017

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Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility

20 March 2017

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hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA

20 March 2017

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Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

20 March 2017

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The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch

20 March 2017

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20 March 2017

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Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction

20 March 2017

1 reference

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Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

20 March 2017

1 reference

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Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism

7 April 2017

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Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks

7 April 2017

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Flap endonuclease 1 mechanism analysis indicates flap base binding prior to threading

29 September 2017

1 reference

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Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeats

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093132

Substrate recognition and catalysis by flap endonucleases and related enzymes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093132

Distinct activities of exonuclease 1 and flap endonuclease 1 at telomeric g4 DNA

29 September 2017

1 reference

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Mechanisms of double-strand break repair in somatic mammalian cells

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093132

Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093132

Combining efficient conformational sampling with a deformable elastic network model facilitates structure refinement at low resolution

29 September 2017

1 reference

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Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity.

29 September 2017

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Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity

29 September 2017

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Reconstitution of 5'-directed human mismatch repair in a purified system

29 September 2017

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Structural basis for recruitment of human flap endonuclease 1 to PCNA

29 September 2017

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Roles of divalent metal ions in flap endonuclease-substrate interactions.

29 September 2017

1 reference

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Modeling of Flap Endonuclease Interactions with DNA Substrate

29 September 2017

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Role of DNA mismatch repair defects in the pathogenesis of human cancer

29 September 2017

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Interactions of mutant and wild-type flap endonucleases with oligonucleotide substrates suggest an alternative model of DNA binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093132

Functional analysis of point mutations in human flap endonuclease-1 active site

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093132

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

29 September 2017

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Mechanism of tracking and cleavage of adduct-damaged DNA substrates by the mammalian 5'- to 3'-exonuclease/endonuclease RAD2 homologue 1 or flap endonuclease 1.

2 June 2018

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Brønsted analysis and rate-limiting steps for the T5 flap endonuclease catalyzed hydrolysis of exonucleolytic substrates

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093132

Three metal ions participate in the reaction catalyzed by T5 flap endonuclease.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093132

10.1016/J.CELL.2011.03.005

27 November 2018

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

21496642

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