The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes (Q28241779)

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Philip M Reaper

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Andrew R Pettitt

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Paul D Sherrington

Normal expression of the Fanconi anemia proteins FAA and FAC and sensitivity to mitomycin C in two patients with Seckel syndrome.

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language of work or name

English

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publication date

11 March 2004

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published in

Oncogene

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volume

23

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issue

10

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page(s)

1911-21

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cites work

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Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV.

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Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance

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Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts

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Small peptides activate the latent sequence-specific DNA binding function of p53.

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Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation

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p53 sends nucleotides to repair DNA.

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7 January 2021