Regulation of PCNA-protein interactions for genome stability (Q28289142)

PCNA, the maestro of the replication fork

31 March 2020

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The replication clamp-loading machine at work in the three domains of life

31 March 2020

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How a DNA Polymerase Clamp Loader Opens a Sliding Clamp

31 March 2020

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The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9

31 March 2020

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Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

31 March 2020

1 reference

Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae

31 March 2020

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Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells

31 March 2020

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Analysis of replication profiles reveals key role of RFC-Ctf18 in yeast replication stress response

31 March 2020

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ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin

31 March 2020

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CELLULAR DNA REPLICASES: Components and Dynamics at the Replication Fork

31 March 2020

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Three-dimensional structure of the beta subunit of E. coli DNA polymerase III holoenzyme: a sliding DNA clamp

31 March 2020

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Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA

31 March 2020

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Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA

31 March 2020

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Proliferating cell nuclear antigen loaded onto double-stranded DNA: dynamics, minor groove interactions and functional implications.

31 March 2020

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Architecture of the DNA polymerase B-proliferating cell nuclear antigen (PCNA)-DNA ternary complex

31 March 2020

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Structure of a Sliding Clamp on DNA

31 March 2020

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A novel PCNA-binding motif identified by the panning of a random peptide display library

31 March 2020

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Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1.

31 March 2020

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Subtle alterations in PCNA-partner interactions severely impair DNA replication and repair

31 March 2020

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A Heterotrimeric PCNA in the Hyperthermophilic Archaeon Sulfolobus solfataricus

31 March 2020

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Structural basis for recruitment of human flap endonuclease 1 to PCNA

31 March 2020

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Structural insight into recruitment of translesion DNA polymerase Dpo4 to sliding clamp PCNA

31 March 2020

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PCNA directs type 2 RNase H activity on DNA replication and repair substrates

31 March 2020

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Mechanism of replication machinery assembly as revealed by the DNA ligase-PCNA-DNA complex architecture

31 March 2020

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Identification of a novel, widespread, and functionally important PCNA-binding motif

31 March 2020

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Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress

31 March 2020

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Regulating post-translational modifications of the eukaryotic replication clamp PCNA.

31 March 2020

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RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

31 March 2020

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Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

31 March 2020

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Y-family DNA polymerases and their role in tolerance of cellular DNA damage.

31 March 2020

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Suffering in silence: the tolerance of DNA damage

31 March 2020

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Tyrosine phosphorylation controls PCNA function through protein stability

31 March 2020

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Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2

31 March 2020

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DNA polymerases and human disease

31 March 2020

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The RAD6 DNA damage tolerance pathway operates uncoupled from the replication fork and is functional beyond S phase.

31 March 2020

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Ubiquitin-dependent DNA damage bypass is separable from genome replication

31 March 2020

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Mammalian polymerase zeta is essential for post-replication repair of UV-induced DNA lesions

31 March 2020

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Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells

31 March 2020

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PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40.

31 March 2020

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A role for PCNA ubiquitination in immunoglobulin hypermutation

31 March 2020

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Postreplication repair and PCNA modification in Schizosaccharomyces pombe

31 March 2020

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Ubiquitin/SUMO modification of PCNA promotes replication fork progression in Xenopus laevis egg extracts

31 March 2020

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Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination

31 March 2020

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Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage

31 March 2020

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Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities.

31 March 2020

1 reference

Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks

31 March 2020

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Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a.

31 March 2020

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E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6

31 March 2020

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PCNA is ubiquitinated by RNF8

31 March 2020

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SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis

31 March 2020

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CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis

31 March 2020

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Defects in DNA ligase I trigger PCNA ubiquitylation at Lys 107.

31 March 2020

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A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles

31 March 2020

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Systematic and quantitative assessment of the ubiquitin-modified proteome

31 March 2020

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Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen

31 March 2020

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Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis

31 March 2020

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Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin

31 March 2020

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Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage

31 March 2020

1 reference

Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance

31 March 2020

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Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells

31 March 2020

1 reference

Effect of proliferating cell nuclear antigen ubiquitination and chromatin structure on the dynamic properties of the Y-family DNA polymerases

31 March 2020

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Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function

31 March 2020

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Interaction of hREV1 with three human Y-family DNA polymerases

31 March 2020

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Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7

31 March 2020

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Intrinsic flexibility of ubiquitin on proliferating cell nuclear antigen (PCNA) in translesion synthesis.

31 March 2020

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Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange

31 March 2020

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PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells.

31 March 2020

1 reference

REV1 restrains DNA polymerase zeta to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo

31 March 2020

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RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger

31 March 2020

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The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA.

31 March 2020

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Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner

31 March 2020

1 reference

Ubiquitin signalling in DNA replication and repair

31 March 2020

2 references

https://pubmed.ncbi.nlm.nih.gov/23594953

31 March 2020

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination

1 reference

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks

31 March 2020

1 reference

Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination

31 March 2020

1 reference

Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen

31 March 2020

1 reference

HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase

31 March 2020

1 reference

The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress

31 March 2020

1 reference

ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response

31 March 2020

1 reference

HARPing on about the DNA damage response during replication

31 March 2020

1 reference

Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells

31 March 2020

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PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage

31 March 2020

1 reference

Chk1 and Claspin potentiate PCNA ubiquitination

31 March 2020

1 reference

Reversal of PCNA ubiquitylation by Ubp10 in Saccharomyces cerevisiae.

31 March 2020

1 reference

The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types

31 March 2020

1 reference

A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway

31 March 2020

1 reference

Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.

31 March 2020

1 reference

Deubiquitination of FANCD2 is required for DNA crosslink repair

31 March 2020

1 reference

SUMO modification of PCNA is controlled by DNA.

31 March 2020

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SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

31 March 2020

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DNA helicase Srs2 disrupts the Rad51 presynaptic filament

31 March 2020

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The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.

31 March 2020

1 reference

Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p

31 March 2020

1 reference

Crystal Structure of SUMO-Modified Proliferating Cell Nuclear Antigen

31 March 2020

1 reference

Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2

31 March 2020

1 reference

Specification of SUMO1- and SUMO2-interacting motifs

31 March 2020

1 reference

Role of SUMO modification of human PCNA at stalled replication fork

31 March 2020

1 reference

Inhibition of homologous recombination by the PCNA-interacting protein PARI

31 March 2020

1 reference

Elg1, an alternative subunit of the RFC clamp loader, preferentially interacts with SUMOylated PCNA.

31 March 2020

1 reference

Regulation of the Fanconi anemia pathway by a SUMO-like delivery network

31 March 2020

1 reference

Regulation of translesion synthesis DNA polymerase eta by monoubiquitination

31 March 2020

1 reference

Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae

31 March 2020

1 reference

Molecular mechanisms of coupled monoubiquitination

31 March 2020

1 reference

ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage

31 March 2020

1 reference

Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation

31 March 2020

1 reference

Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding

31 March 2020

1 reference

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase

31 March 2020

1 reference

PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication

31 March 2020

1 reference

L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage

31 March 2020

1 reference

An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage

31 March 2020

1 reference

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

31 March 2020

1 reference

PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination

31 March 2020

1 reference

Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage

31 March 2020

1 reference

SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation

31 March 2020

1 reference

CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase

31 March 2020

1 reference

CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation

31 March 2020

1 reference

A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction.

31 March 2020

1 reference

Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2

31 March 2020

1 reference

Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4(Cdt2) -mediated proteolysis

31 March 2020

1 reference

Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2.

31 March 2020

1 reference

Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase

31 March 2020

1 reference

Regulated proteolysis of DNA polymerase eta during the DNA-damage response in C. elegans

31 March 2020

1 reference

Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation.

31 March 2020

1 reference

Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass

31 March 2020

1 reference

p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation.

31 March 2020

1 reference

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

31 March 2020

1 reference

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.

31 March 2020

1 reference

DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

31 March 2020

1 reference

DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage

31 March 2020

1 reference

Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis

31 March 2020

1 reference

Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response

31 March 2020

1 reference

Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance

31 March 2020

1 reference

Finally, polyubiquitinated PCNA gets recognized

31 March 2020

1 reference

Error-prone translesion synthesis mediates acquired chemoresistance

31 March 2020

1 reference

Suppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapy

31 March 2020

1 reference

Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication

31 March 2020

1 reference

Timing and spacing of ubiquitin-dependent DNA damage bypass

31 March 2020

1 reference

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

31 March 2020

1 reference

hRAD30 mutations in the variant form of xeroderma pigmentosum

31 March 2020

1 reference

REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo

31 March 2020

1 reference

Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair.

31 March 2020

1 reference

Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

31 March 2020

1 reference

Regulation of monoubiquitinated PCNA by DUB autocleavage

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23594953

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM3562

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1024069318

0 references

Fatcat ID

release_xhzbdomgbnaffbhil56ailyc7m

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/xhzbdomgbnaffbhil56ailyc7m

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

23594953

1 reference

Consolidated OpenCitations Corpus – April 2017