Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence (Q28472787)

9

0 references

David Y. Thomas

object named as

David Y Thomas

8

0 references

Malcolm Whiteway

11

object named as

Malcolm Whiteway

0 references

author name string

Elias Epp

1

0 references

Ghyslaine Vanier

2

0 references

Doreen Harcus

3

0 references

Anna Y Lee

4

0 references

Michael Hallett

6

0 references

Don C Sheppard

7

0 references

Alaka Mullick

Creative Commons Attribution 4.0 International

10

0 references

language of work or name

English

0 references

publication date

5 February 2010

0 references

published in

PLOS Pathogens

0 references

volume

6

0 references

issue

2

0 references

page(s)

e1000753

0 references

copyright license

start time

5 February 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Role of Ndt80p in sterol metabolism regulation and azole resistance in Candida albicans.

29 September 2017

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29 September 2017

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A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds

29 September 2017

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Genome-wide mapping of the coactivator Ada2p yields insight into the functional roles of SAGA/ADA complex in Candida albicans

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Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

29 September 2017

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29 September 2017

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An integrated platform of genomic assays reveals small-molecule bioactivities

29 September 2017

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29 September 2017

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A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate.

29 September 2017

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29 September 2017

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Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance

29 September 2017

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Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance

29 September 2017

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Transcription factor substitution during the evolution of fungal ribosome regulation

29 September 2017

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Regulation of actin cytoskeleton dynamics by Arf-family GTPases

29 September 2017

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The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype.

29 September 2017

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Antimicrobial resistance: resistance to antifungal agents: mechanisms and clinical impact

29 September 2017

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Paradoxical growth effects of the echinocandins caspofungin and micafungin, but not of anidulafungin, on clinical isolates of Candida albicans and C. dubliniensis

29 September 2017

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Recent advances and challenges in the treatment of invasive fungal infections

29 September 2017

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Genome-wide expression and location analyses of the Candida albicans Tac1p regulon.

29 September 2017

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The small G proteins of the Arf family and their regulators

29 September 2017

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Morphogenesis in Candida albicans

29 September 2017

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Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections

29 September 2017

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Sequence resources at the Candida Genome Database

29 September 2017

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ArfGAP family proteins in cell adhesion, migration and tumor invasion.

29 September 2017

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Synthesis and anticancer activity of brefeldin A ester derivatives

29 September 2017

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Time course of microbiologic outcome and gene expression in Candida albicans during and following in vitro and in vivo exposure to fluconazole

29 September 2017

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Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi

29 September 2017

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29 September 2017

Emerging fungal diseases

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Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans

29 September 2017

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Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans

29 September 2017

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29 September 2017

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Rare and emerging opportunistic fungal pathogens: concern for resistance beyond Candida albicans and Aspergillus fumigatus.

29 September 2017

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Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain

29 September 2017

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Paradoxical effect of caspofungin: reduced activity against Candida albicans at high drug concentrations

29 September 2017

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Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

29 September 2017

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New modules for PCR-based gene targeting in Candida albicans: rapid and efficient gene targeting using 100 bp of flanking homology region

29 September 2017

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Calcineurin is essential for virulence in Candida albicans

29 September 2017

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Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents

29 September 2017

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The genetic basis of fluconazole resistance development in Candida albicans

29 September 2017

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29 September 2017

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Candida albicans sterol C-14 reductase, encoded by the ERG24 gene, as a potential antifungal target site

21 January 2018

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The direct cost and incidence of systemic fungal infections

29 September 2017

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Calcineurin is essential for survival during membrane stress in Candida albicans

29 September 2017

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The Gcs1 and Age2 ArfGAP proteins provide overlapping essential function for transport from the yeast trans-Golgi network

29 September 2017

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Fluconazole plus cyclosporine: a fungicidal combination effective against experimental endocarditis due to Candida albicans

29 September 2017

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Elucidation of strict structural requirements of brefeldin A as an inducer of differentiation and apoptosis

29 September 2017

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Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors

29 September 2017

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Brefeldin A-mediated apoptosis requires the activation of caspases and is inhibited by Bcl-2.

29 September 2017

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Yeast glycosylation mutants are sensitive to aminoglycosides

29 September 2017

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Aneuploid chromosomes are highly unstable during DNA transformation of Candida albicans

29 September 2017

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Candida albicans Mds3p, a conserved regulator of pH responses and virulence identified through insertional mutagenesis.

2 June 2018

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Mutants of Kluyveromyces lactis with altered protein glycosylation are affected in cell wall morphogenesis.

2 June 2018

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Brefeldin A binds to glutathione S-transferase and is secreted as glutathione and cysteine conjugates by Chinese hamster ovary cells

2 June 2018

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Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: a multicenter, prospective, observational study in France (2005-2006).

2 June 2018

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Candida infection in HIV positive patients 1985-2007.

21 January 2018

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A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in patients with invasive candidiasis.

21 January 2018

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Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence

21 January 2018

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Molecules in the ARF orbit

21 January 2018

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Structural Basis for Activation of ARF GTPase

21 January 2018

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The zinc cluster transcription factor Tac1p regulates PDR16 expression in Candida albicans

21 January 2018

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CRZ1, a target of the calcineurin pathway in Candida albicans

21 January 2018

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Evolution of eukaryotic transcription circuits

21 January 2018

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Preparation and evaluation of sulfide derivatives of the antibiotic brefeldin a as potential prodrug candidates with enhanced aqueous solubilities

21 January 2018

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Calcineurin is required for Candida albicans to survive calcium stress in serum

21 January 2018

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PCR-based gene targeting in Candida albicans.

21 January 2018

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The SAT1 flipper, an optimized tool for gene disruption in Candida albicans

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12 December 2020

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10.1371/JOURNAL.PPAT.1000753

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

20140196

1 reference