Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion (Q28582459)

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English	Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion	scientific journal article

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scholarly article

1 reference

31 January 2017

Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion (English)

1 reference

31 January 2017

0 references

1 reference

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inferred from title

author name string

Karim Bouzakri

1

1 reference

31 January 2017

Pascale Ribaux

2

1 reference

31 January 2017

Philippe A. Halban

3

1 reference

31 January 2017

language of work or name

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publication date

9 October 2009

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31 January 2017

Journal of Biological Chemistry

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31 January 2017

284

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31 January 2017

41

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31 January 2017

27892–27898

1 reference

31 January 2017

S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788840

17 March 2017

p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation

1 reference

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17 March 2017

Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788840

17 March 2017

Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase

1 reference

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17 March 2017

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

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17 March 2017

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

1 reference

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23 March 2017

Mechanisms linking obesity to insulin resistance and type 2 diabetes

1 reference

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7 April 2017

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

1 reference

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7 April 2017

C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus

1 reference

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Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

1 reference

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29 September 2017

Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop

1 reference

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The role of inflammation in insulitis and beta-cell loss in type 1 diabetes

1 reference

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29 September 2017

Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle

1 reference

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29 September 2017

Tumour necrosis factor-alpha-induced glucose-stimulated insulin secretion inhibition in INS-1 cells is ascribed to a reduction of the glucose-stimulated Ca2+ influx

1 reference

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29 September 2017

Islet inflammation in type 2 diabetes: from metabolic stress to therapy.

1 reference

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29 September 2017

The protein kinases ERK1/2 and their roles in pancreatic beta cells

1 reference

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29 September 2017

The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis

1 reference

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29 September 2017

Cytokines and beta-cell biology: from concept to clinical translation

1 reference

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29 September 2017

Tumor necrosis factor (TNF) biology and cell death

1 reference

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29 September 2017

Metabolic syndrome: a solution in search of a problem

1 reference

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29 September 2017

Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.

1 reference

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29 September 2017

siRNA produced by recombinant dicer mediates efficient gene silencing in islet cells

1 reference

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29 September 2017

Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells

1 reference

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29 September 2017

Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion

1 reference

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29 September 2017

Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells

1 reference

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29 September 2017

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus

1 reference

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Positive and negative regulation of glucose uptake by hyperosmotic stress

1 reference

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29 September 2017

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788840

29 September 2017

Pheromone response, mating and cell biology

1 reference

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29 September 2017

Importance of cell-matrix interactions in rat islet beta-cell secretion in vitro: role of alpha6beta1 integrin

1 reference

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29 September 2017

The expression of TNF alpha by human muscle. Relationship to insulin resistance

1 reference

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29 September 2017

Role of cytokines in inducing hyperlipidemia

1 reference

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29 September 2017

Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788840

3 June 2018

Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788840

3 June 2018

Relationship between serum tumor necrosis factor-alpha and insulin resistance in obese men with Type 2 diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.048058

21 January 2018

Elevated serum tumor necrosis factor-alpha concentrations and bioactivity in Type 2 diabetics and patients with android type obesity

1 reference

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21 January 2018

Identification of insulin signaling elements in human beta-cells: autocrine regulation of insulin gene expression.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.048058

21 January 2018

Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.048058

21 January 2018

MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.048058

21 January 2018

Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation

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https://api.crossref.org/works/10.1074%2FJBC.M109.048058

21 January 2018

Proliferation of sorted human and rat beta cells

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https://api.crossref.org/works/10.1074%2FJBC.M109.048058

21 January 2018

Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells.

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https://api.crossref.org/works/10.1074%2FJBC.M109.048058

21 January 2018

Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.048058

21 January 2018

C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study

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https://api.crossref.org/works/10.1074%2FJBC.M109.048058

21 January 2018

Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study

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https://api.crossref.org/works/10.1074%2FJBC.M109.048058

21 January 2018

Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

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https://api.crossref.org/works/10.1074%2FJBC.M109.048058

21 January 2018

Advances in male contraception

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21 January 2018

Exercise-Induced Phosphorylation of the Novel Akt Substrates AS160 and Filamin A in Human Skeletal Muscle

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https://api.crossref.org/works/10.1074%2FJBC.M109.048058

21 January 2018

Regulation of pancreatic -cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway

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https://pubmed.ncbi.nlm.nih.gov/19690174

12 December 2020

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Pro-Survival Role of Gelsolin in Mouse -Cells

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https://pubmed.ncbi.nlm.nih.gov/19690174

12 December 2020

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Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19690174

12 December 2020

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Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19690174

12 December 2020

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Uvomorulin mediates calcium-dependent aggregation of islet cells, whereas calcium-independent cell adhesion molecules distinguish between islet cell types

1 reference

https://pubmed.ncbi.nlm.nih.gov/19690174

12 December 2020

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19690174

12 December 2020

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