Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice (Q80059540)

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28 December 2019

title

Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice (English)

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28 December 2019

1

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28 December 2019

Colin Selman

4

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28 December 2019

Shanta J. Persaud

8

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28 December 2019

Dominic J Withers

9

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28 December 2019

author name string

A I Choudhury

2

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28 December 2019

H Asare-Anane

3

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28 December 2019

S Lingard

5

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28 December 2019

H Heffron

6

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28 December 2019

P Herrera

7

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28 December 2019

Anane-Asare, H.

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Cantley, J.

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Choudhury, A. I.

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Selman, C.

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Lingard, S.

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Heffron, H.

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Herrera, P.

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Persaud, S. J.

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Withers, D. J.

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publication date

29 March 2007

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28 December 2019

2007

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published in

Diabetologia

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28 December 2019

volume

50

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issue

6

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page(s)

1248-1256

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https://scigraph.springernature.com/pub.10.1007/s00125-007-0637-9

28 December 2019

exact match

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http://ugspace.ug.edu.gh/handle/123456789/957

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cites work

A key role for beta-cell cytosolic phospholipase A(2) in the maintenance of insulin stores but not in the initiation of insulin secretion

1 reference

12 December 2020

Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3.

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12 December 2020

A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.

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Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.

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12 December 2020

New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass

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12 December 2020

New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

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12 December 2020

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus

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12 December 2020

The role of insulin receptor substrate 2 in hypothalamic and beta cell function.

1 reference

12 December 2020

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes

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12 December 2020

Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass

1 reference

12 December 2020

Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67

1 reference

12 December 2020

Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice

1 reference

12 December 2020

IRS-2 pathways integrate female reproduction and energy homeostasis

1 reference

12 December 2020

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes

1 reference

12 December 2020

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

1 reference

12 December 2020

Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice

1 reference

12 December 2020

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

12 December 2020

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

1 reference

12 December 2020

Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells.

1 reference

12 December 2020

Pdx1 restores beta cell function in Irs2 knockout mice

1 reference

12 December 2020

Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways.

1 reference

12 December 2020

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.

1 reference

12 December 2020

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

1 reference

12 December 2020

Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells

1 reference

12 December 2020

Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells

1 reference

12 December 2020

Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells.

1 reference

12 December 2020

Identification of insulin-producing cells derived from embryonic stem cells by zinc-chelating dithizone

1 reference

12 December 2020

RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function

1 reference

12 December 2020

beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass

1 reference

12 December 2020

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

1 reference

12 December 2020

PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

1 reference

12 December 2020

Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

1 reference

12 December 2020

10.1007/S00125-007-0637-9

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17393136%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

28 December 2019

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