Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway (Q28592687)

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author name string

Xudong Yang

1

1 reference

31 January 2017

Rüdiger Klein

2

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31 January 2017

Xiaolin Tian

3

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31 January 2017

Jie Shen

High-frequency developmental abnormalities in p53-deficient mice.

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31 January 2017

language of work or name

English

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publication date

1 May 2004

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31 January 2017

Developmental Biology

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31 January 2017

269

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31 January 2017

1

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31 January 2017

81–94

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31 January 2017

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Notch signaling: cell fate control and signal integration in development

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A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

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Notch is required for successive cell decisions in the developing Drosophila retina.

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Correlating notch signaling with thymocyte maturation

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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Xotch inhibits cell differentiation in the Xenopus retina

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TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

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rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cells

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Radial glial identity is promoted by Notch1 signaling in the murine forebrain

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Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation.

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Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex

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Characterization of CNS precursor subtypes and radial glia

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Maintenance of neuroepithelial progenitor cells by Delta–Notch signalling in the embryonic chick retina

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Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

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Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands

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Variations on the Notch pathway in neural development

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Targeted oncogene activation by site-specific recombination in transgenic mice

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Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development

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p53, the cellular gatekeeper for growth and division

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Notch and the birth of glial cells

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Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

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Arbiter of differentiation and death: Notch signaling meets apoptosis

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Short-range cell interactions and cell survival in the Drosophila wing.

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p63 is a p53 homologue required for limb and epidermal morphogenesis

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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Asymmetric inheritance of radial glial fibers by cortical neurons

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Cell cycle arrest and apoptosis induced by Notch1 in B cells

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Neuronal potential and lineage determination by neural stem cells

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Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells

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Notch signaling: from the outside in

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A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

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Notch1 functions as a tumor suppressor in mouse skin

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Neurons derived from radial glial cells establish radial units in neocortex

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The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

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Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

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Deficient T cell fate specification in mice with an induced inactivation of Notch1.

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Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

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A subset of p53-deficient embryos exhibit exencephaly

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

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Presenilin is required for activity and nuclear access of Notch in Drosophila

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Notch1 is essential for postimplantation development in mice.

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Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate

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Tumor-suppressor p53 is expressed in proliferating and newly formed neurons of the embryonic and postnatal rat brain: comparison with expression of the cell cycle regulators p21Waf1/Cip1, p27Kip1, p57Kip2, p16Ink4a, cyclin G1, and the proto-oncogene

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Up a notch: instructing gliogenesis

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Notch signaling: direct or what?

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SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

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Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

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p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

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On the shoulders of giants: p63, p73 and the rise of p53.

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Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

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Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors.

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