Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling (Q33619056)

28 July 2017

title

Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling (English)

1 reference

28 July 2017

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1 reference

GOA release 2020-03-11

Norbert Perrimon

6

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author name string

Lutz Kockel

1

1 reference

28 July 2017

Kimberly S Kerr

2

1 reference

28 July 2017

Michael Melnick

3

1 reference

28 July 2017

Katja Brückner

4

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28 July 2017

Matthias Hebrok

5

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28 July 2017

publication date

17 June 2010

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28 July 2017

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28 July 2017

volume

6

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28 July 2017

issue

6

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28 July 2017

page(s)

e1000990

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Creative Commons Attribution 4.0 International

28 July 2017

copyright license

start time

17 June 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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The Akt-mTOR tango and its relevance to cancer

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Rheb binds and regulates the mTOR kinase

21 June 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 June 2018

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Dysregulation of the TSC-mTOR pathway in human disease

21 June 2018

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Tuberous sclerosis and insulin resistance. Unlikely bedfellows reveal a TORrid affair

21 June 2018

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21 June 2018

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Tsc2 is not a critical target of Akt during normal Drosophila development

21 June 2018

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Argos inhibits epidermal growth factor receptor signalling by ligand sequestration

21 June 2018

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The LKB1 tumor suppressor negatively regulates mTOR signaling

21 June 2018

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

21 June 2018

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21 June 2018

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21 June 2018

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TSC2 mediates cellular energy response to control cell growth and survival

21 June 2018

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Rhebbing up mTOR: New Insights on TSC1 and TSC2, and the Pathogenesis of Tuberous Sclerosis

21 June 2018

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Rheb fills a GAP between TSC and TOR.

21 June 2018

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

21 June 2018

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The molecular target of rapamycin (mTOR) as a therapeutic target against cancer

21 June 2018

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The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

21 June 2018

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Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway

21 June 2018

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Rheb promotes cell growth as a component of the insulin/TOR signalling network

21 June 2018

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GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

21 June 2018

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Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

21 June 2018

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Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

21 June 2018

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Akt regulates growth by directly phosphorylating Tsc2

21 June 2018

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 June 2018

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 June 2018

1 reference

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Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

21 June 2018

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The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

21 June 2018

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TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

21 June 2018

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Feedback control of intercellular signalling in development

21 June 2018

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A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

21 June 2018

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Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.

21 June 2018

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Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

21 June 2018

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Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

21 June 2018

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Cellular survival: a play in three Akts

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887466

Primer3 on the WWW for general users and for biologist programmers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887466

Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887466

Negative feedback mechanisms and their roles during pattern formation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887466

Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887466

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887466

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887466

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2887466

The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis.

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000990

Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000990

Patching the gaps in Hedgehog signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000990

Drosophila S6 kinase: a regulator of cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000990

Discrete functions of rictor and raptor in cell growth regulation in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000990

Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000990

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000990

Genetic analysis of protein kinase B (AKT) in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000990

Genetic mosaic techniques for studying Drosophila development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000990

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000990

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000990

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000990

Altering Drosophila S6 kinase activity is consistent with a role for S6 kinase in growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000990

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000990

10.1371/JOURNAL.PGEN.1000990

21 January 2018

Identifiers

DOI

1 reference

28 July 2017

1 reference

28 July 2017

1 reference