Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease (Q33402434)

26 July 2017

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title

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease (English)

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26 July 2017

3

Peter Carmeliet

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26 July 2017

Peter Fraisl

1

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PubMed ID

19165233

26 July 2017

Julián Aragonés

series ordinal

2

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26 July 2017

23 January 2009

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Nature Reviews Drug Discovery

26 July 2017

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26 July 2017

8

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26 July 2017

139-152

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26 July 2017

2

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https://scigraph.springernature.com/pub.10.1038/nrd2761

26 July 2017

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cites work

Targeting HIF-1 for cancer therapy

1 reference

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

31 March 2020

1 reference

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

31 March 2020

1 reference

A conserved family of prolyl-4-hydroxylases that modify HIF

31 March 2020

1 reference

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

31 March 2020

1 reference

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

31 March 2020

1 reference

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

31 March 2020

1 reference

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

31 March 2020

1 reference

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

31 March 2020

1 reference

Oxygen sensors in context

31 March 2020

1 reference

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

31 March 2020

1 reference

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

31 March 2020

1 reference

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].

31 March 2020

1 reference

Hypoxia tolerance in mammals and birds: from the wilderness to the clinic

31 March 2020

1 reference

31 March 2020

Hypoxic reprogramming

1 reference

Hypoxic tolerance in air-breathing invertebrates

31 March 2020

1 reference

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

31 March 2020

1 reference

Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning

31 March 2020

1 reference

Angiogenesis: where do we stand now?

31 March 2020

1 reference

Mechanisms of angiogenesis and arteriogenesis

31 March 2020

1 reference

Hypoxia--a key regulatory factor in tumour growth

31 March 2020

1 reference

Regulation of angiogenesis by hypoxia: role of the HIF system

31 March 2020

1 reference

Intramyocardial injection of naked DNA encoding HIF-1alpha/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat.

31 March 2020

1 reference

Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor

31 March 2020

1 reference

Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse

31 March 2020

1 reference

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.

31 March 2020

1 reference

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

31 March 2020

1 reference

Prolyl hydroxylase domain 2 protein suppresses hypoxia-induced endothelial cell proliferation

31 March 2020

1 reference

Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases

31 March 2020

1 reference

Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.

31 March 2020

1 reference

Effect of indomethacin on hydralazine-induced renin and catecholamine release in the conscious rabbit

31 March 2020

1 reference

Renin gene transfer restores angiogenesis and vascular endothelial growth factor expression in Dahl S rats

31 March 2020

1 reference

Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat.

31 March 2020

1 reference

Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system

31 March 2020

1 reference

Reduction of ischemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia.

31 March 2020

1 reference

Neuroprotection of ischemic brain by vascular endothelial growth factor is critically dependent on proper dosage and may be compromised by angiogenesis

31 March 2020

1 reference

Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice.

31 March 2020

1 reference

Why do cancers have high aerobic glycolysis?

31 March 2020

1 reference

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

31 March 2020

1 reference

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

31 March 2020

1 reference

A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas

31 March 2020

1 reference

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

31 March 2020

1 reference

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

31 March 2020

1 reference

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

31 March 2020

1 reference

Hypoxia-induced energy stress regulates mRNA translation and cell growth

31 March 2020

1 reference

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

31 March 2020

1 reference

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

31 March 2020

1 reference

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

31 March 2020

1 reference

Mammalian Hibernation: Cellular and Molecular Responses to Depressed Metabolism and Low Temperature

31 March 2020

1 reference

Genes controlling the metabolic switch in hibernating mammals

31 March 2020

1 reference

Low-temperature carbon utilization is regulated by novel gene activity in the heart of a hibernating mammal

31 March 2020

1 reference

Coordinate expression of the PDK4 gene: a means of regulating fuel selection in a hibernating mammal

31 March 2020

1 reference

Seasonal changes in serum lipids and proteins in the 13-lined ground squirrel.

31 March 2020

1 reference

The role of dietary fatty acids in the evolution of spontaneous and facultative hibernation patterns in prairie dogs.

31 March 2020

1 reference

Hypoxia tolerance in mammalian heterotherms.

31 March 2020

1 reference

Hibernation, a model of neuroprotection

31 March 2020

1 reference

Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure

31 March 2020

1 reference

Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury

31 March 2020

1 reference

Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mouse liver ischemia-reperfusion.

31 March 2020

1 reference

Oxygen, hypoxia, and stress.

31 March 2020

1 reference

Oxygen, the lead actor in the pathophysiologic drama: enactment of the trinity of normoxia, hypoxia, and hyperoxia in disease and therapy

31 March 2020

1 reference

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

31 March 2020

1 reference

Myocardial hibernation: a delicate balance.

31 March 2020

1 reference

Hibernating myocardium retains metabolic and contractile reserve despite regional reductions in flow, function, and oxygen consumption at rest

31 March 2020

1 reference

Persistent regional downregulation in mitochondrial enzymes and upregulation of stress proteins in swine with chronic hibernating myocardium

31 March 2020

1 reference

Program of cell survival underlying human and experimental hibernating myocardium

31 March 2020

1 reference

Persistent stunning induces myocardial hibernation and protection: flow/function and metabolic mechanisms.

31 March 2020

1 reference

Myocardial metabolism of 123I-BMIPP during low-flow ischaemia in an experimental model: comparison with myocardial blood flow and 18F-FDG.

31 March 2020

1 reference

Metabolic changes in hibernating myocardium after percutaneous transluminal coronary angioplasty and the relation between recovery in left ventricular function and free fatty acid metabolism

31 March 2020

1 reference

31 March 2020

Hibernating myocardium.

1 reference

The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition

31 March 2020

1 reference

HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation

31 March 2020

1 reference

Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes

31 March 2020

1 reference

Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation.

31 March 2020

1 reference

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

31 March 2020

1 reference

Characteristics of renal tubular atrophy in experimental renovascular hypertension: a model of kidney hibernation

31 March 2020

1 reference

A hibernating kidney - ischemic preconditioning in a renal transplant recipient with a proximal stenosis of the iliac artery

31 March 2020

1 reference

Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia.

31 March 2020

1 reference

Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states.

31 March 2020

1 reference

Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats

31 March 2020

1 reference

Insulin-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options

31 March 2020

1 reference

Lipid accumulation in non-adipose tissue and lipotoxicity

31 March 2020

1 reference

Early stress protein gene expression in a human model of ischemic preconditioning.

31 March 2020

1 reference

Adenosine-dependent activation of hypoxia-inducible factor-1 induces late preconditioning in liver cells

31 March 2020

1 reference

Ischemic Pre-conditioning in Deceased Donor Liver Transplantation: A Prospective Randomized Clinical Trial

31 March 2020

1 reference

Protective role of ecto-5'-nucleotidase (CD73) in renal ischemia

31 March 2020

1 reference

Cerebral preconditioning and ischaemic tolerance

31 March 2020

1 reference

Hypoxic preconditioning protects against ischemic brain injury

31 March 2020

1 reference

Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain

31 March 2020

1 reference

Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha

31 March 2020

1 reference

Deferoxamine induces prolonged cardiac preconditioning via accumulation of oxygen radicals

31 March 2020

1 reference

Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS.

31 March 2020

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Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain

31 March 2020

1 reference

The neuroprotective effect of deferoxamine in the hypoxic-ischemic immature mouse brain

31 March 2020

1 reference

Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney

31 March 2020

1 reference

Ischemic preconditioning: from molecular mechanisms to therapeutic opportunities

31 March 2020

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Molecular physiology of preconditioning-induced brain tolerance to ischemia

31 March 2020

1 reference

Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia

31 March 2020

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HIF-dependent induction of adenosine A2B receptor in hypoxia

31 March 2020

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The reno-vascular A2B adenosine receptor protects the kidney from ischemia

31 March 2020

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Ischemic preconditioning protects by activating prosurvival kinases at reperfusion

31 March 2020

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Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury

31 March 2020

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The reperfusion injury salvage kinase pathway: a common target for both ischemic preconditioning and postconditioning.

31 March 2020

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The role of mitochondria in protection of the heart by preconditioning.

31 March 2020

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Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection

31 March 2020

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Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury

31 March 2020

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PTEN activity is modulated during ischemia and reperfusion: involvement in the induction and decay of preconditioning

31 March 2020

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PTEN, the Achilles' heel of myocardial ischaemia/reperfusion injury?

31 March 2020

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Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase

31 March 2020

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Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation

31 March 2020

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Attenuation of reperfusion injury by renal ischaemic preconditioning: the role of nitric oxide

31 March 2020

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Inducible nitric-oxide synthase is an important contributor to prolonged protective effects of ischemic preconditioning in the mouse kidney.

31 March 2020

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The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene

31 March 2020

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Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury

31 March 2020

1 reference

HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration

31 March 2020

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Long-term tolerance to retinal ischemia by repetitive hypoxic preconditioning: role of HIF-1alpha and heme oxygenase-1

31 March 2020

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Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain.

31 March 2020

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Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt.

31 March 2020

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Up-regulated HIF-1alpha is involved in the hypoxic tolerance induced by hyperbaric oxygen preconditioning

31 March 2020

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Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin.

31 March 2020

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Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury.

31 March 2020

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Ischemic preconditioning is mediated by erythropoietin through PI-3 kinase signaling in an animal model of transient ischemic attack

31 March 2020

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The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

31 March 2020

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Inhibition of toll-like receptor and cytokine signaling--a unifying theme in ischemic tolerance

31 March 2020

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Regional manifestations and control of the immune system

31 March 2020

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Modulation of leukocyte behavior by an inflamed extracellular matrix

31 March 2020

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Hypoxia inducible factor (HIF) function in innate immunity and infection

31 March 2020

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HIF-1alpha is essential for myeloid cell-mediated inflammation

31 March 2020

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HIF-1alpha expression in response to lipopolysaccaride mediates induction of hepatic inflammatory cytokine TNFalpha

31 March 2020

1 reference

Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis

31 March 2020

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HIF-1alpha expression regulates the bactericidal capacity of phagocytes

31 March 2020

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Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis

31 March 2020

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Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity

31 March 2020

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Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

31 March 2020

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NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha

31 March 2020

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LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner

31 March 2020

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Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores

31 March 2020

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Hypoxia and gastrointestinal disease

31 March 2020

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Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.

31 March 2020

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The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis.

31 March 2020

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Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.

31 March 2020

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IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

31 March 2020

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Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival

31 March 2020

1 reference

Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

31 March 2020

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Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation

31 March 2020

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Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice

31 March 2020

1 reference

Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia

31 March 2020

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EPAS1 promotes adipose differentiation in 3T3-L1 cells

31 March 2020

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Transcriptional regulation of the hypoxia inducible factor-2alpha (HIF-2alpha) gene during adipose differentiation in 3T3-L1 cells

31 March 2020

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Effects of prolyl hydroxylase inhibitors on adipogenesis and hypoxia inducible factor 1 alpha levels under normoxic conditions.

31 March 2020

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Prolyl-hydroxylase inhibition and HIF activation in osteoblasts promotes an adipocytic phenotype.

31 March 2020

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Selective inhibition of factor inhibiting hypoxia-inducible factor

31 March 2020

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Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway

31 March 2020

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Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

31 March 2020

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Oxygen sensing by HIF hydroxylases

31 March 2020

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Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress

31 March 2020

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Mitochondrial dysfunction via disruption of complex II activity during iron chelation-induced senescence-like growth arrest of Chang cells.

31 March 2020

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Arachidonic acid metabolism

31 March 2020

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Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer

31 March 2020

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A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia.

31 March 2020

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Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway

31 March 2020

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Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

31 March 2020

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Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains

31 March 2020

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The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability

31 March 2020

1 reference

The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)

31 March 2020

1 reference

OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha

31 March 2020

1 reference

The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).

31 March 2020

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Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis

31 March 2020

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Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau

31 March 2020

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Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

31 March 2020

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Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

31 March 2020

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Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

31 March 2020

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A gain-of-function mutation in the HIF2A gene in familial erythrocytosis

31 March 2020

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A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

31 March 2020

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Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

31 March 2020

1 reference

Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors

31 March 2020

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The human side of hypoxia-inducible factor

31 March 2020

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HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia

31 March 2020

1 reference

Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues

31 March 2020

1 reference

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

31 March 2020

1 reference

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase

31 March 2020

1 reference

A role for hypoxia-inducible factor-1alpha in desferoxamine neuroprotection.

31 March 2020

1 reference

Inhibition of prolyl hydroxylation during collagen biosynthesis in human skin fibroblast cultures by ethyl 3,4-dihydroxybenzoate

31 March 2020

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Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors

31 March 2020

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Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction

31 March 2020

1 reference

The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis

31 March 2020

1 reference

Antiproliferative and antifibrotic effects of mimosine on adult cardiac fibroblasts1Previously published in abstract form: Circulation 94(8) (1996) I 355.1

31 March 2020

1 reference

Specific inhibition of eIF-5A and collagen hydroxylation by a single agent. Antiproliferative and fibrosuppressive effects on smooth muscle cells from human coronary arteries

31 March 2020

1 reference

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases

31 March 2020

1 reference

Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors

31 March 2020

1 reference

Design and synthesis of a series of novel pyrazolopyridines as HIF-1alpha prolyl hydroxylase inhibitors

31 March 2020

1 reference

Reduction of collagen production in keloid fibroblast cultures by ethyl-3,4-dihydroxybenzoate. Inhibition of prolyl hydroxylase activity as a mechanism of action

31 March 2020

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12 December 2020

Mitochondrial oxygen affinity, respiratory flux control and excess capacity of cytochrome c oxidase.

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12 December 2020

Partial identity of the 2-oxoglutarate and ascorbate binding sites of prolyl 4-hydroxylase

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12 December 2020

Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD2761

1 reference

26 July 2017

1 reference

PubMed ID

19165233