Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia (Q33702409)

28 July 2017

title

Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia (English)

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28 July 2017

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21

Hagop Kantarjian

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28 July 2017

13

Tapan Kadia

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28 July 2017

1

Marina Konopleva

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28 July 2017

22

Anthony Letai

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28 July 2017

12

Courtney D DiNardo

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28 July 2017

5

Leah Hogdal

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28 July 2017

17

Joel Leverson

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28 July 2017

2

Daniel A Pollyea

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28 July 2017

3

Jalaja Potluri

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4

Brenda Chyla

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28 July 2017

18

Rod Humerickhouse

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28 July 2017

19

Mack Mabry

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28 July 2017

Todd Busman

6

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28 July 2017

Evelyn McKeegan

7

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28 July 2017

Ahmed Hamed Salem

8

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28 July 2017

Ming Zhu

9

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28 July 2017

Justin L Ricker

10

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28 July 2017

William Blum

11

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28 July 2017

Martin Dunbar

14

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Rachel Kirby

15

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Nancy Falotico

16

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28 July 2017

Richard Stone

20

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28 July 2017

publication date

12 August 2016

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28 July 2017

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28 July 2017

volume

6

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28 July 2017

issue

10

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28 July 2017

page(s)

1106-1117

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Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

28 July 2017

cites work

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21 June 2018

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21 June 2018

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21 June 2018

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Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia

21 June 2018

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BH3 profiling discriminates response to cytarabine-based treatment of acute myelogenous leukemia

21 June 2018

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Role of DNMT3A, TET2, and IDH1/2 mutations in pre-leukemic stem cells in acute myeloid leukemia

21 June 2018

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BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells

21 June 2018

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

21 June 2018

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Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

21 June 2018

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Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5436271

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

21 June 2018

1 reference

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Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer

21 June 2018

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Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

21 June 2018

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BH3 profiling--measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions

21 June 2018

1 reference

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Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

21 June 2018

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Recurring mutations found by sequencing an acute myeloid leukemia genome

21 June 2018

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The Bcl-2 apoptotic switch in cancer development and therapy

21 June 2018

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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

21 June 2018

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

21 June 2018

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

21 June 2018

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Age and acute myeloid leukemia

21 June 2018

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Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia

21 June 2018

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Acute myeloid leukemia in the elderly: biology and therapeutic strategies.

21 June 2018

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ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets.

21 June 2018

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Intensive chemotherapy does not benefit most older patients (age 70 years or older) with acute myeloid leukemia

30 October 2018

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Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

30 October 2018

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Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation.

30 October 2018

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Prognostic index for adult patients with acute myeloid leukemia in first relapse

30 October 2018

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12 December 2020

Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome: predictive prognostic models for outcome

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12 December 2020

The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia

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12 December 2020

A new Leukemia Prognostic Scoring System for refractory/relapsed adult acute myelogeneous leukaemia patients: a GOELAMS study

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12 December 2020

Phase I study of ABT-199 (GDC-0199) in patients with relapsed/refractory non-Hodgkin lymphoma: responses observed in diffuse large B-cell (DLBCL) and follicular lymphoma (FL) at higher cohort doses

1 reference

12 December 2020

10.1158/2159-8290.CD-16-0313

Identifiers

DOI

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28 July 2017

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28 July 2017

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