Towards a systems understanding of MHC class I and MHC class II antigen presentation. (Q34029353)

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16 January 2020

title

Towards a systems understanding of MHC class I and MHC class II antigen presentation (English)

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16 January 2020

3

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16 January 2020

Oddmund Bakke

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4

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16 January 2020

author name string

Jacques Neefjes

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1

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16 January 2020

Marlieke L M Jongsma

series ordinal

2

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16 January 2020

publication date

11 November 2011

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Nature Reviews Immunology

16 January 2020

published in

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16 January 2020

volume

11

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16 January 2020

page(s)

823-836

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16 January 2020

issue

12

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The known unknowns of antigen processing and presentation.

16 January 2020

cites work

1 reference

Cross-priming in health and disease.

31 March 2020

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LAMP-2-deficient human B cells exhibit altered MHC class II presentation of exogenous antigens

31 March 2020

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Viral evasion of T cell immunity: ancient mechanisms offering new applications

31 March 2020

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Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome

31 March 2020

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Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channel

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The major substrates for TAP in vivo are derived from newly synthesized proteins

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Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.

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Widespread RNA and DNA sequence differences in the human transcriptome.

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New lane in the information highway: alternative reading frame peptides elicit T cells with potent antiretrovirus activity

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Viral alteration of cellular translational machinery increases defective ribosomal products

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Innate immune and chemically triggered oxidative stress modifies translational fidelity.

31 March 2020

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Distinct pathways generate peptides from defective ribosomal products for CD8+ T cell immunosurveillance

31 March 2020

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Cutting edge: neosynthesis is required for the presentation of a T cell epitope from a long-lived viral protein

31 March 2020

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An antigenic peptide produced by peptide splicing in the proteasome

31 March 2020

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Immune recognition of a human renal cancer antigen through post-translational protein splicing.

31 March 2020

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An antigenic peptide produced by reverse splicing and double asparagine deamidation

31 March 2020

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Allele and locus-specific differences in cell surface expression and the association of HLA class I heavy chain with beta 2-microglobulin: differential effects of inhibition of glycosylation on class I subunit association

31 March 2020

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Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

31 March 2020

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Differential microRNA regulation of HLA-C expression and its association with HIV control

31 March 2020

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Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation

31 March 2020

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Both treated and untreated tumors are eliminated by short hairpin RNA-based induction of target-specific immune responses

31 March 2020

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Insights into MHC class I antigen processing gained from large-scale analysis of class I ligands

31 March 2020

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AAA+ proteases: ATP-fueled machines of protein destruction

31 March 2020

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26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

31 March 2020

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The role of the proteasome in the generation of MHC class I ligands and immune responses

31 March 2020

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Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products

31 March 2020

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Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells.

31 March 2020

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Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress

31 March 2020

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Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I.

31 March 2020

1 reference

The quality control of MHC class I peptide loading

31 March 2020

1 reference

Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing

31 March 2020

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Essential glycan-dependent interactions optimize MHC class I peptide loading

31 March 2020

1 reference

Tapasin is a facilitator, not an editor, of class I MHC peptide binding.

31 March 2020

1 reference

ABC proteins in antigen translocation and viral inhibition

31 March 2020

1 reference

Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells

31 March 2020

1 reference

ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

31 March 2020

1 reference

Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum.

31 March 2020

1 reference

An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides

31 March 2020

1 reference

The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues

31 March 2020

1 reference

Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling

31 March 2020

1 reference

Cross-presentation by intercellular peptide transfer through gap junctions.

31 March 2020

1 reference

Direct antigen presentation and gap junction mediated cross-presentation during apoptosis.

31 March 2020

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Bacteria-induced gap junctions in tumors favor antigen cross-presentation and antitumor immunity.

31 March 2020

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HLA genomics in the third millennium

31 March 2020

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HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading.

31 March 2020

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Additive contribution of HLA class I alleles in the immune control of HIV-1 infection

31 March 2020

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Uniquely conformed peptide-containing beta 2-microglobulin-free heavy chains of HLA-B2705 on the cell surface

31 March 2020

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Cutting edge: HLA-B27 acquires many N-terminal dibasic peptides: coupling cytosolic peptide stability to antigen presentation.

31 March 2020

1 reference

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

31 March 2020

1 reference

Quantitating protein synthesis, degradation, and endogenous antigen processing

31 March 2020

1 reference

Making sense of mass destruction: quantitating MHC class I antigen presentation

31 March 2020

1 reference

A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation.

31 March 2020

1 reference

Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation

31 March 2020

1 reference

Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII.

31 March 2020

1 reference

Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes

31 March 2020

1 reference

Analysis of the role of tripeptidyl peptidase II in MHC class I antigen presentation in vivo

31 March 2020

1 reference

Complexity, contradictions, and conundrums: studying post-proteasomal proteolysis in HLA class I antigen presentation.

31 March 2020

1 reference

The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation

31 March 2020

1 reference

Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action.

31 March 2020

1 reference

Protein targeting and degradation are coupled for elimination of mislocalized proteins

31 March 2020

1 reference

Modeling the MHC class I pathway by combining predictions of proteasomal cleavage, TAP transport and MHC class I binding

31 March 2020

1 reference

Major histocompatibility complex class I binding predictions as a tool in epitope discovery.

31 March 2020

1 reference

Class I HLA folding and antigen presentation in beta 2-microglobulin-defective Daudi cells

31 March 2020

1 reference

Recycling MHC class I molecules and endosomal peptide loading

31 March 2020

1 reference

Localization of the conformational alteration of MHC molecules induced by the association of mouse class I heavy chain with a xenogeneic beta 2-microglobulin

31 March 2020

1 reference

The fate of the three subunits of major histocompatibility complex class I molecules

31 March 2020

1 reference

Efficient internalization of MHC I requires lysine-11 and lysine-63 mixed linkage polyubiquitin chains.

31 March 2020

1 reference

Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins

31 March 2020

1 reference

Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules

31 March 2020

1 reference

Defining the role of the MHC in autoimmunity: a review and pooled analysis

31 March 2020

1 reference

HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide

31 March 2020

1 reference

Right place, right time, right peptide: DO keeps DM focused

31 March 2020

1 reference

Regulation of MHC class II expression and antigen processing in murine and human mesenchymal stromal cells by IFN-gamma, TGF-beta, and cell density

31 March 2020

1 reference

MHC class II expression by the gut epithelium

31 March 2020

1 reference

Metachromasia of 3-amino-9-ethylcarbazole (AEC) and its prevention in immunoperoxidase techniques

31 March 2020

1 reference

Antigen presentation and MHC class II expression by human esophageal epithelial cells: role in eosinophilic esophagitis

31 March 2020

1 reference

Upregulation of cathepsin S in psoriatic keratinocytes

31 March 2020

1 reference

Regulation of major histocompatibility complex class II genes

31 March 2020

1 reference

Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA.

31 March 2020

1 reference

Regulation of MHC class II gene expression by the class II transactivator

31 March 2020

1 reference

Positive regulatory domain I (PRDM1) and IRF8/PU.1 counter-regulate MHC class II transactivator (CIITA) expression during dendritic cell maturation

31 March 2020

1 reference

Phosphorylation of class II transactivator regulates its interaction ability and transactivation function.

31 March 2020

1 reference

Serine residues 286, 288, and 293 within the CIITA: a mechanism for down-regulating CIITA activity through phosphorylation

31 March 2020

1 reference

Phosphorylation and ubiquitination of degron proximal residues are essential for class II transactivator (CIITA) transactivation and major histocompatibility class II expression

31 March 2020

1 reference

Enhancement of CIITA transcriptional function by ubiquitin

31 March 2020

1 reference

A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation

31 March 2020

1 reference

Accessory molecules for MHC class II peptide loading

31 March 2020

1 reference

MHC II and the endocytic pathway: regulation by invariant chain.

31 March 2020

1 reference

Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain

31 March 2020

1 reference

Mice lacking the MHC class II-associated invariant chain

31 March 2020

1 reference

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression

31 March 2020

1 reference

A cytosolic pathway for MHC class II-restricted antigen processing that is proteasome and TAP dependent

31 March 2020

1 reference

The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains

31 March 2020

1 reference

AP2 clathrin adaptor complex, but not AP1, controls the access of the major histocompatibility complex (MHC) class II to endosomes.

31 March 2020

1 reference

Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments

31 March 2020

1 reference

Involvement of caspase-cleaved and intact adaptor protein 1 complex in endosomal remodeling in maturing dendritic cells

31 March 2020

1 reference

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

31 March 2020

1 reference

Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments

31 March 2020

1 reference

Association of distinct tetraspanins with MHC class II molecules at different subcellular locations in human immature dendritic cells

31 March 2020

1 reference

The lysosomal cysteine proteases in MHC class II antigen presentation

31 March 2020

1 reference

A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes.

31 March 2020

1 reference

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

31 March 2020

1 reference

Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape.

31 March 2020

1 reference

Endosomally stored MHC class II does not contribute to antigen presentation by dendritic cells at inflammatory conditions.

31 March 2020

1 reference

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

31 March 2020

1 reference

The cytoplasmic tail of invariant chain regulates endosome fusion and morphology

31 March 2020

1 reference

Invariant chain increases the half-life of MHC II by delaying endosomal maturation.

31 March 2020

1 reference

Presentation of type B peptide-MHC complexes from hen egg white lysozyme by TLR ligands and type I IFNs independent of H2-DM regulation

31 March 2020

1 reference

Activation of lysosomal function during dendritic cell maturation

31 March 2020

1 reference

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning

31 March 2020

1 reference

Statins affect cell-surface expression of major histocompatibility complex class II molecules by disrupting cholesterol-containing microdomains

31 March 2020

1 reference

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

31 March 2020

1 reference

Developmental regulation of MHC class II transport in mouse dendritic cells.

31 March 2020

1 reference

T-cell engagement of dendritic cells rapidly rearranges MHC class II transport.

31 March 2020

1 reference

Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface

31 March 2020

1 reference

Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells

31 March 2020

1 reference

The actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation.

31 March 2020

1 reference

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

31 March 2020

1 reference

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

31 March 2020

1 reference

Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination

31 March 2020

1 reference

Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes

31 March 2020

1 reference

Interleukin-10 down-regulates MHC class II alphabeta peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling.

31 March 2020

1 reference

CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation.

31 March 2020

1 reference

Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production.

31 March 2020

1 reference

Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells

31 March 2020

1 reference

MHC class II signaling in antigen-presenting cells

31 March 2020

1 reference

MHC class II engagement by its ligand LAG-3 (CD223) contributes to melanoma resistance to apoptosis.

31 March 2020

1 reference

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk

31 March 2020

1 reference

TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-alpha/beta dimers.

31 March 2020

1 reference

The low-affinity receptor for IgE (CD23) on B lymphocytes is spatially associated with HLA-DR antigens

31 March 2020

1 reference

Therapeutic vaccination against human papilloma virus induced malignancies

31 March 2020

1 reference

A universal approach to eliminate antigenic properties of alpha-gliadin peptides in celiac disease

31 March 2020

1 reference

Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity

31 March 2020

1 reference

Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation

31 March 2020

1 reference

Studies on the subsite specificity of rat nardilysin (N-arginine dibasic convertase).

31 March 2020

1 reference

Nardilysin cleaves peptides at monobasic sites

31 March 2020

1 reference

The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation

31 March 2020

1 reference

Regulation of cell-surface major histocompatibility complex class I expression by the endopeptidase EC3.4.24.15 (thimet oligopeptidase).

31 March 2020

1 reference

Protein degradation and the generation of MHC class I-presented peptides.

31 March 2020

1 reference

Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation

31 March 2020

1 reference

Two new proteases in the MHC class I processing pathway

31 March 2020

1 reference

Production of an antigenic peptide by insulin-degrading enzyme

31 March 2020

1 reference

Expression of angiotensin-converting enzyme changes major histocompatibility complex class I peptide presentation by modifying C termini of peptide precursors

31 March 2020

1 reference

The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism.

31 March 2020

1 reference

In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides.

31 March 2020

1 reference

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

31 March 2020

1 reference

Cutting edge: MHC class II expression by pulmonary nonhematopoietic cells plays a critical role in controlling local inflammatory responses

31 March 2020

1 reference

Editing of the HLA-DR-peptide repertoire by HLA-DM

31 March 2020

1 reference

12 December 2020

Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing

1 reference

12 December 2020

Antigen presentation by interferon-gamma-treated endothelial cells and fibroblasts: differential ability to function as antigen-presenting cells despite comparable Ia expression

1 reference

12 December 2020

Autophagy and adaptive immunity

1 reference

12 December 2020

The MHC class II-associated invariant chain: a molecule with multiple roles in MHC class II biosynthesis and antigen presentation to CD4+ T cells

1 reference

12 December 2020

Anti-Ia-reactive cells in mycosis fungoides: a study of skin biopsies, single epidermal cells and circulating T lymphocytes

1 reference

12 December 2020

Reduced cell surface expression of HLA-C molecules correlates with restricted peptide binding and stable TAP interaction

1 reference

12 December 2020

The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules

1 reference

12 December 2020

A caspase-independent pathway of MHC class II antigen-mediated apoptosis of human B lymphocytes

1 reference

12 December 2020

Combining radiation and immunotherapy for synergistic antitumor therapy.

1 reference

12 December 2020