The macro domain protein family: structure, functions, and their potential therapeutic implications (Q34172087)

31 July 2017

1 reference

title

The macro domain protein family: structure, functions, and their potential therapeutic implications (English)

1 reference

31 July 2017

0 references

1 reference

Weidong Han

1

1 reference

31 July 2017

Xiaolei Li

series ordinal

2

1 reference

31 July 2017

Xiaobing Fu

series ordinal

3

1 reference

31 July 2017

language of work or name

English

0 references

publication date

21 March 2011

1 reference

31 July 2017

1 reference

31 July 2017

727

1 reference

31 July 2017

3

1 reference

31 July 2017

86-103

1 reference

Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.

31 July 2017

1 reference

12 December 2020

Chromatin modifications and their function

1 reference

12 December 2020

Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains

1 reference

12 December 2020

Endogenous ADP-ribosylation of the G protein beta subunit prevents the inhibition of type 1 adenylyl cyclase

1 reference

12 December 2020

A biochemical genomics approach for identifying genes by the activity of their products.

1 reference

12 December 2020

Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

1 reference

12 December 2020

PARP inhibition sensitizes p53-deficient breast cancer cells to doxorubicin-induced apoptosis.

1 reference

12 December 2020

Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions

1 reference

12 December 2020

Poly(ADP-ribose): novel functions for an old molecule

1 reference

12 December 2020

Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells

1 reference

12 December 2020

Role of H2AX in DNA damage response and human cancers.

1 reference

12 December 2020

Discovering new ADP-ribose polymer cycles: protecting the genome and more

1 reference

12 December 2020

Developmental changes in histone macroH2A1-mediated gene regulation

1 reference

12 December 2020

Replication-dependent radiosensitization of human glioma cells by inhibition of poly(ADP-Ribose) polymerase: mechanisms and therapeutic potential

1 reference

12 December 2020

Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors

1 reference

12 December 2020

Diphtheria toxin subunit active in vitro

1 reference

12 December 2020

ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models

1 reference

12 December 2020

Developmental and tissue expression patterns of histone macroH2A1 subtypes

1 reference

12 December 2020

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

1 reference

12 December 2020

Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

1 reference

12 December 2020

The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity

1 reference

12 December 2020

Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma.

1 reference

12 December 2020

Histone macroH2A isoforms predict the risk of lung cancer recurrence

1 reference

12 December 2020

Up-regulation of LRP16 mRNA by 17beta-estradiol through activation of estrogen receptor alpha (ERalpha), but not ERbeta, and promotion of human breast cancer MCF-7 cell proliferation: a preliminary report

1 reference

12 December 2020

Poly(ADP-ribose) (PAR) polymer is a death signal

1 reference

12 December 2020

The macro domain is an ADP-ribose binding module

1 reference

12 December 2020

Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure

1 reference

12 December 2020

DNA double-strand breaks: signaling, repair and the cancer connection

1 reference

12 December 2020

Histone shuttling by poly(ADP-ribosylation)

1 reference

12 December 2020

The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing

1 reference

12 December 2020

Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single-stranded DNA damages to double-stranded DNA breaks.

1 reference

12 December 2020

Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome

1 reference

12 December 2020

A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein.

1 reference

12 December 2020

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

1 reference

12 December 2020

Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

1 reference

12 December 2020

1 reference

12 December 2020

Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals

1 reference

12 December 2020

Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily

1 reference

12 December 2020

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

1 reference

12 December 2020

Collaborator of Stat6 (CoaSt6)-associated poly(ADP-ribose) polymerase activity modulates Stat6-dependent gene transcription

1 reference

12 December 2020

Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1

1 reference

12 December 2020

Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor

1 reference

12 December 2020

Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90

1 reference

12 December 2020

Clinicopathological significance of LRP16 protein in 336 gastric carcinoma patients

1 reference

12 December 2020

Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

1 reference

12 December 2020

Negative control of p53 by Sir2alpha promotes cell survival under stress

1 reference

12 December 2020

Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines

1 reference

12 December 2020

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

1 reference

12 December 2020

The macroPARP genes Parp-9 and Parp-14 are developmentally and differentially regulated in mouse tissues.

1 reference

12 December 2020

A proteomic approach to the identification of heterogeneous nuclear ribonucleoproteins as a new family of poly(ADP-ribose)-binding proteins

1 reference

12 December 2020

Effects of single or split exposure of leukemic cells to temozolomide, combined with poly(ADP-ribose) polymerase inhibitors on cell growth, chromosomal aberrations and base excision repair components.

1 reference

12 December 2020

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

1 reference

12 December 2020

The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding Pocket

1 reference

12 December 2020

A phosphorylated subpopulation of the histone variant macroH2A1 is excluded from the inactive X chromosome and enriched during mitosis

1 reference

12 December 2020

Endogenous mono-ADP-ribosylation of the free Gbetagamma prevents stimulation of phosphoinositide 3-kinase-gamma and phospholipase C-beta2 and is activated by G-protein-coupled receptors.

1 reference

12 December 2020

Poly(ADP-ribose) polymerase 1 is inhibited by a histone H2A variant, MacroH2A, and contributes to silencing of the inactive X chromosome.

1 reference

12 December 2020

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

1 reference

12 December 2020

Stealth and mimicry by deadly bacterial toxins

1 reference

12 December 2020

Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase

1 reference

12 December 2020

Chromodomain helicase/adenosine triphosphatase DNA binding protein 1-like (CHD1l) gene suppresses the nucleus-to-mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survival.

1 reference

12 December 2020

Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.

1 reference

12 December 2020

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

1 reference

12 December 2020

The RXR heterodimers and orphan receptors

1 reference

12 December 2020

Estrogenically regulated LRP16 interacts with estrogen receptor alpha and enhances the receptor's transcriptional activity

1 reference

12 December 2020

Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler

1 reference

12 December 2020

Potential chemotherapeutic activity of 4-iodo-3-nitrobenzamide. Metabolic reduction to the 3-nitroso derivative and induction of cell death in tumor cells in culture

1 reference

12 December 2020

The crystal structure of AF1521 a protein from Archaeoglobus fulgidus with homology to the non-histone domain of macroH2A

1 reference

12 December 2020

Poly(ADP-ribosyl)ation as a DNA damage-induced post-translational modification regulating poly(ADP-ribose) polymerase-1-topoisomerase I interaction

1 reference

12 December 2020

The C20orf133 gene is disrupted in a patient with Kabuki syndrome

1 reference

12 December 2020

The mouse X chromosome is enriched for sex-biased genes not subject to selection by meiotic sex chromosome inactivation

1 reference

12 December 2020

macroH2A1-dependent silencing of endogenous murine leukemia viruses

1 reference

12 December 2020

Transgenic CHD1L expression in mouse induces spontaneous tumors

1 reference

12 December 2020

MacroH2A, a core histone containing a large nonhistone region

1 reference

12 December 2020

DNA repair pathways as targets for cancer therapy

1 reference

12 December 2020

p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction

1 reference

12 December 2020

Targeting the ubiquitin system in cancer therapy

1 reference

12 December 2020

BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration

1 reference

12 December 2020

PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells.

1 reference

12 December 2020

The single-macro domain protein LRP16 is an essential cofactor of androgen receptor

1 reference

12 December 2020

A novel poly(ADP-ribose) polymerase inhibitor, ABT-888, radiosensitizes malignant human cell lines under hypoxia

1 reference

12 December 2020

Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity

1 reference

12 December 2020

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

1 reference

12 December 2020

Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century

1 reference

12 December 2020

Clinicopathological significance and prognostic value of LRP16 expression in colorectal carcinoma

1 reference

12 December 2020

Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma.

1 reference

12 December 2020

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

1 reference

12 December 2020

The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling

1 reference

12 December 2020

Histone macroH2A1.2 is concentrated in the XY-body by the early pachytene stage of spermatogenesis

1 reference

12 December 2020

The family of bacterial ADP-ribosylating exotoxins

1 reference

12 December 2020

Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

1 reference

12 December 2020

Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system

1 reference

12 December 2020

Nur77 as a survival factor in tumor necrosis factor signaling

1 reference

12 December 2020

Conserved metabolic regulatory functions of sirtuins

1 reference

12 December 2020

Evolutionary conservation of histone macroH2A subtypes and domains

1 reference

12 December 2020

Differential activities of cellular and viral macro domain proteins in binding of ADP-ribose metabolites

1 reference

12 December 2020

Clinicopathological significance and prognostic value of leukemia-related protein 16 expression in invasive ductal breast carcinoma

1 reference

12 December 2020

[Expression and clinical significance of LRP16 gene in human breast cancer]

1 reference

12 December 2020

CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients.

1 reference

12 December 2020

Mechanism of polymerase II transcription repression by the histone variant macroH2A.

1 reference

12 December 2020

Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins

1 reference

12 December 2020

Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation.

1 reference

12 December 2020

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

1 reference

12 December 2020

Splicing regulates NAD metabolite binding to histone macroH2A.

1 reference

12 December 2020

The role of poly(ADP-ribosyl)ation in epigenetic events.

1 reference

12 December 2020

4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.

1 reference

12 December 2020

Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models

1 reference

12 December 2020

MACROH2A2, a new member of the MARCOH2A core histone family

1 reference

12 December 2020

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

1 reference

12 December 2020

Identification of multiple distinct Snf2 subfamilies with conserved structural motifs.

1 reference

12 December 2020

Genome maintenance mechanisms for preventing cancer

1 reference

12 December 2020

Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin

1 reference

12 December 2020

(ADP-ribose)n participates in DNA excision repair

1 reference

12 December 2020

Serologic markers of effective tumor immunity against chronic lymphocytic leukemia include nonmutated B-cell antigens.

1 reference

12 December 2020

Meiotic sex chromosome inactivation in male mice with targeted disruptions of Xist

1 reference

12 December 2020

Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?

1 reference

12 December 2020

Combining affinity purification by ADP-ribose-binding macro domains with mass spectrometry to define the mammalian ADP-ribosyl proteome

1 reference

12 December 2020

Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.

1 reference

12 December 2020

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

1 reference

12 December 2020

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

1 reference

12 December 2020

B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity

1 reference

12 December 2020

Inhibition of apoptosis by Nur77 through NF-kappaB activity modulation

1 reference

12 December 2020

The WWE domain: a common interaction module in protein ubiquitination and ADP ribosylation

1 reference

12 December 2020

Poly(ADP-ribose) polymerase-1 and ionizing radiation: sensor, signaller and therapeutic target

1 reference

12 December 2020

The histone variant macroH2A is an epigenetic regulator of key developmental genes

1 reference

12 December 2020

Classification of anticancer drugs—a new system based on therapeutic targets

1 reference

12 December 2020

A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation

1 reference

12 December 2020

Inactivating chromosomes: a macro domain that minimizes transcription

1 reference

12 December 2020

Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism.

1 reference

12 December 2020

Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion.

1 reference

12 December 2020

Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer

1 reference

12 December 2020

The nsP3 macro domain is important for Sindbis virus replication in neurons and neurovirulence in mice

1 reference

12 December 2020

Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP

1 reference

12 December 2020

Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry

1 reference

12 December 2020

Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor

1 reference

12 December 2020

10.1016/J.MRREV.2011.03.001

Identifiers

DOI

1 reference

31 July 2017

1 reference