Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity (Q34275062)

1 August 2017

Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity (English)

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1 August 2017

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recombination signal binding protein for immunoglobulin kappa J region

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negative regulation of cold-induced thermogenesis

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Notch 1

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Recombination signal binding protein for immunoglobulin kappa J region

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Pengpeng Bi

1

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Shihuan Kuang

object named as

Shihuan Kuang

11

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author name string

Tizhong Shan

2

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1 August 2017

Weiyi Liu

3

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1 August 2017

Feng Yue

4

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1 August 2017

Xin Yang

5

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1 August 2017

Xin-Rong Liang

6

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1 August 2017

Jinghua Wang

7

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1 August 2017

Jie Li

8

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1 August 2017

Nadia Carlesso

9

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1 August 2017

Xiaoqi Liu

10

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1 August 2017

language of work or name

English

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publication date

20 July 2014

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1 August 2017

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1 August 2017

20

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1 August 2017

911-918

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1 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nm.3615

1 August 2017

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cites work

The nuclear receptor Rev-erbα controls circadian thermogenic plasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Obesity induced a leptin-Notch signaling axis in breast cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Fat cells directly sense temperature to activate thermogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

A heterogeneous lineage origin underlies the phenotypic and molecular differences of white and beige adipocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Effect of soluble Jagged1-mediated inhibition of Notch signaling on proliferation and differentiation of an adipocyte progenitor cell model

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Bi-directional interconversion of brite and white adipocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Lessons on conditional gene targeting in mouse adipose tissue

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

A novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Constitutive Notch activation upregulates Pax7 and promotes the self-renewal of skeletal muscle satellite cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Transcriptional control of adipose lipid handling by IRF4

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Nonshivering thermogenesis and its adequate measurement in metabolic studies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

The Notch signaling pathway: molecular basis of cell context dependency

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

The changed metabolic world with human brown adipose tissue: therapeutic visions.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Impact of age on the relationships of brown adipose tissue with sex and adiposity in humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Transplantation of adipose tissue and stem cells: role in metabolism and disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Functional brown adipose tissue in healthy adults

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Identification and importance of brown adipose tissue in adult humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Cold-activated brown adipose tissue in healthy men

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Adipocytes as regulators of energy balance and glucose homeostasis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Notch signalling: a simple pathway becomes complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Obesity is associated with macrophage accumulation in adipose tissue

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Notch signaling controls multiple steps of pancreatic differentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

The influence of genetic background on the expression of the obese (ob) gene in the mouse

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181850

Evidence for two types of brown adipose tissue in humans.

6 July 2018

1 reference

White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma

21 January 2018

1 reference

UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic.

21 January 2018

1 reference

Active form Notch4 promotes the proliferation and differentiation of 3T3-L1 preadipocytes

21 January 2018

1 reference

Inhibition of gamma-secretases alters both proliferation and differentiation of mesenchymal stem cells.

21 January 2018

1 reference

Notch signalling inhibits the adipogenic differentiation of single-cell-derived mesenchymal stem cell clones isolated from human adipose tissue.

21 January 2018

1 reference

gamma-secretase inhibitor induces adipogenesis of adipose-derived stem cells by regulation of Notch and PPAR-gamma.

21 January 2018

1 reference

Selective expression of an aP2/Fatty Acid Binding Protein 4-Cre transgene in non-adipogenic tissues during embryonic development.

21 January 2018

1 reference

Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.

21 January 2018

1 reference

Hedgehog signaling is dispensable for adult hematopoietic stem cell function

21 January 2018

1 reference

Notch pathway is dispensable for adipocyte specification

21 January 2018

1 reference

12 December 2020

The role of leptin in human physiology

1 reference

12 December 2020

THERMOREGULATORY AND ADAPTIVE BEHAVIOR OF BROWN ADIPOSE TISSUE

1 reference

12 December 2020

Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans

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12 December 2020

Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision

1 reference

12 December 2020

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

1 reference

12 December 2020

Ectopic recombination in the central and peripheral nervous system by aP2/FABP4-Cre mice: implications for metabolism research

1 reference

12 December 2020

GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha

1 reference

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NM.3615

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1 August 2017

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1 August 2017

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