Mechanism of activation of protein kinase JAK2 by the growth hormone receptor (Q34420222)

2 August 2017

Mechanism of activation of protein kinase JAK2 by the growth hormone receptor (English)

1 reference

2 August 2017

Yash Chhabra

5

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Emma Sierecki

Emma Sierecki

12

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Daniel Abankwa

Daniel Abankwa

4

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Guillermo A. Gomez

Guillermo A Gomez

14

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Manolis Doxastakis

Manolis Doxastakis

17

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Andrew J. Brooks

Andrew J Brooks

1

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Craig J Morton

Craig J Morton

10

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Kirill Alexandrov

Kirill Alexandrov

15

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Megan L O'Mara

Megan L O'Mara

3

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Alan Mark

Alan E Mark

18

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Michael W Parker

Michael W Parker

11

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Yann Gambin

Yann Gambin

13

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author name string

Wei Dai

2

1 reference

2 August 2017

Rebecca A Pelekanos

6

1 reference

2 August 2017

Olivier Gardon

7

1 reference

2 August 2017

Kathryn A Tunny

8

1 reference

2 August 2017

Kristopher M Blucher

9

1 reference

2 August 2017

Ian A Wilson

16

1 reference

2 August 2017

Michael J Waters

19

1 reference

2 August 2017

language of work or name

English

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publication date

1 May 2014

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2 August 2017

1 reference

2 August 2017

344

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2 August 2017

1249783

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2 August 2017

6185

1 reference

The growth hormone receptor: mechanism of activation and clinical implications

2 August 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Rational design of potent antagonists to the human growth hormone receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Binding in the growth hormone receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Model for growth hormone receptor activation based on subunit rotation within a receptor dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Ligand-independent dimerization of the human prolactin receptor isoforms: functional implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Dimerisation of the glycophorin A transmembrane segment in membranes probed with the ToxR transcription activator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

The interface between self-assembling erythropoietin receptor transmembrane segments corresponds to a membrane-spanning leucine zipper

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Homo-FRET imaging as a tool to quantify protein and lipid clustering

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Dynamic imaging of homo-FRET in live cells by fluorescence anisotropy microscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Full characterization of GPCR monomer-dimer dynamic equilibrium by single molecule imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Dimerization of receptor protein-tyrosine phosphatase alpha in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Receptor-like protein tyrosine phosphatase alpha homodimerizes on the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Surface-exposed positions in the transmembrane helices of the lactose permease of Escherichia coli determined by intermolecular thiol cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Disulfide linkage of growth hormone (GH) receptors (GHR) reflects GH-induced GHR dimerization. Association of JAK2 with the GHR is enhanced by receptor dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Growth hormone (GH)-independent dimerization of GH receptor by a leucine zipper results in constitutive activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Design and implementation of bimolecular fluorescence complementation (BiFC) assays for the visualization of protein interactions in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Spatio-temporal kinetics of growth hormone receptor signaling in single cells using FRET microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

New insights into growth hormone action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

The MARTINI Coarse-Grained Force Field: Extension to Proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Lipid-modulated sequence-specific association of glycophorin A in membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Insights into the recognition and association of transmembrane alpha-helices. The free energy of alpha-helix dimerization in glycophorin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

GxxxG motifs, phenylalanine, and cholesterol guide the self-association of transmembrane domains of ErbB2 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Influence of flanking residues on tilt and rotation angles of transmembrane peptides in lipid bilayers. A solid-state 2H NMR study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Turning the growth hormone receptor on: evidence that hormone binding induces subunit rotation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

The ubiquitin-proteasome pathway regulates the availability of the GH receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Interferon-induced nuclear signalling by Jak protein tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Active conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Orientation-specific signalling by thrombopoietin receptor dimers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Signal transduction mediated by growth hormone receptor and its chimeric molecules with the granulocyte colony-stimulating factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

A FRET map of membrane anchors suggests distinct microdomains of heterotrimeric G proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Accelerating flat-histogram methods for potential of mean force calculations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Self-association of models of transmembrane domains of ErbB receptors in a lipid bilayer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

A biomolecular force field based on the free enthalpy of hydration and solvation: the GROMOS force-field parameter sets 53A5 and 53A6

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Systematic molecular dynamics searching in a lipid bilayer: application to the glycophorin A and oncogenic ErbB-2 transmembrane domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

A computer perspective of membranes: molecular dynamics studies of lipid bilayer systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Generation of mammalian cells stably expressing multiple genes at predetermined levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

A versatile viral system for expression and depletion of proteins in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Circular polymerase extension cloning of complex gene libraries and pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Plat-E: an efficient and stable system for transient packaging of retroviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Unraveling functional and structural interactions between transmembrane domains IV and XI of NhaA Na+/H+ antiporter of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Quantitative fluorescence resonance energy transfer measurements using fluorescence microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

An analytic solution to the Förster energy transfer problem in two dimensions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Pronounced conformational changes following agonist activation of the M(3) muscarinic acetylcholine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Increased site 1 affinity improves biopotency of porcine growth hormone. Evidence against diffusion dependent receptor dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: coral red (dsRed) and yellow (Citrine).

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

HADDOCK versus HADDOCK: new features and performance of HADDOCK2.0 on the CAPRI targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

HADDOCK: a protein-protein docking approach based on biochemical or biophysical information

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

GROMACS molecule & liquid database

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Definition and testing of the GROMOS force-field versions 54A7 and 54B7

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Computer simulation of the dynamics of hydrated protein crystals and its comparison with x-ray data

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

VMD: visual molecular dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Species-independent translational leaders facilitate cell-free expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Direct single-molecule observation of a protein living in two opposed native structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Molecular dynamics with coupling to an external bath

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1249783

1 reference

2 August 2017

1 reference