Cyclooxygenase inhibitors modulate the p53/HDM2 pathway and enhance chemotherapy-induced apoptosis in neuroblastoma. (Q34567032)

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30 December 2019

title

Cyclooxygenase inhibitors modulate the p53/HDM2 pathway and enhance chemotherapy-induced apoptosis in neuroblastoma (English)

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30 December 2019

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1

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30 December 2019

author name string

L M Hansford

2

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30 December 2019

L S Cheng

3

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30 December 2019

M Hang

4

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30 December 2019

S Baruchel

5

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30 December 2019

D R Kaplan

6

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30 December 2019

M S Irwin

7

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30 December 2019

language of work or name

English

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publication date

18 September 2006

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30 December 2019

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30 December 2019

volume

26

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30 December 2019

issue

13

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30 December 2019

page(s)

1920-1931

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209981

30 December 2019

exact match

0 references

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Increased frequency of aberrations in the p53/MDM2/p14(ARF) pathway in neuroblastoma cell lines established at relapse

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Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis.

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The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2

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Requirement for HDM2 activity in the rapid degradation of p53 in neuroblastoma

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Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo

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Identifiers

DOI

10.1038/SJ.ONC.1209981

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16983334%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

30 December 2019

0 references

1 reference