Target identification for small bioactive molecules: finding the needle in the haystack (Q34589404)

3 August 2017

title

Target identification for small bioactive molecules: finding the needle in the haystack (English)

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3 August 2017

4

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3 August 2017

Slava Ziegler

1

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3 August 2017

Verena Pries

series ordinal

2

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3 August 2017

Christian Hedberg

series ordinal

3

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3 August 2017

language of work or name

English

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publication date

18 February 2013

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Angewandte Chemie International Edition

3 August 2017

published in

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volume

52

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3 August 2017

issue

10

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3 August 2017

page(s)

2744-2792

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Chemical genetics to chemical genomics: small molecules offer big insights

3 August 2017

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Ammosamides A and B target myosin

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Identification of a novel protein regulating microtubule stability through a chemical approach

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Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

21 January 2018

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Properties of 13C-Substituted Arginine in Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)

21 January 2018

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Identifying the proteins to which small-molecule probes and drugs bind in cells

21 January 2018

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Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

21 January 2018

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21 January 2018

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Fully functionalized small-molecule probes for integrated phenotypic screening and target identification

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Microarrays of tagged combinatorial triazine libraries in the discovery of small-molecule ligands of human IgG.

21 January 2018

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Identification of the F1F0 mitochondrial ATPase as a target for modulating skin pigmentation by screening a tagged triazine library in zebrafish

21 January 2018

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Forward chemical genetic approach identifies new role for GAPDH in insulin signaling

21 January 2018

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Two-dimensional gel electrophoresis in proteomics: Past, present and future

21 January 2018

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The discovery and mechanism of action of novel tumor-selective and apoptosis-inducing 3,5-diaryl-1,2,4-oxadiazole series using a chemical genetics approach

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A comparison of immobilized pH gradient isoelectric focusing and strong-cation-exchange chromatography as a first dimension in shotgun proteomics.

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Target identification using drug affinity responsive target stability (DARTS)

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Pulse proteolysis: A simple method for quantitative determination of protein stability and ligand binding

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Simplified proteomics approach to discover protein-ligand interactions.

21 January 2018

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Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements.

21 January 2018

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Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization.

21 January 2018

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Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components

21 January 2018

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Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents

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An information-intensive approach to the molecular pharmacology of cancer.

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Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm.

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Site of action of two novel pyrimidine biosynthesis inhibitors accurately predicted by the compare program.

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Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

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Expression profiling identifies epoxy anthraquinone derivative as a DNA topoisomerase inhibitor

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MT7, a novel compound from a combinatorial library, arrests mitosis via inhibiting the polymerization of microtubules

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Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways

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Identification of novel hair-growth inducers by means of connectivity mapping

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1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Fluorescent two-dimensional difference gel electrophoresis unveils the potential of gel-based proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Multidimensional drug profiling by automated microscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A morphological biosensor for mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Chemical strategies for generating protein biochips

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Protein microarrays: novel developments and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

UPA, a universal protein array system for quantitative detection of protein-protein, protein-DNA, protein-RNA and protein-ligand interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Membrane protein microarrays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of novel substrates for Cdk5 and new targets for Cdk5 inhibitors using high-density protein microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Relating protein pharmacology by ligand chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Predicting new molecular targets for known drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A ligand-based approach to mining the chemogenomic space of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

PASS: prediction of activity spectra for biologically active substances

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Yeast-based functional genomics and proteomics technologies: the first 15 years and beyond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Functional profiling of the Saccharomyces cerevisiae genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Barcode technology in yeast: application to pharmacogenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Genomic profiling of drug sensitivities via induced haploinsufficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Genome-wide screening of Saccharomyces cerevisiae to identify genes required for antibiotic insusceptibility of eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Genome-wide screen identifies genes whose inactivation confer resistance to cisplatin in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Small ubiquitin-related modifier pathway is a major determinant of doxorubicin cytotoxicity in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A universal TagModule collection for parallel genetic analysis of microorganisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Towards high-throughput characterization of small molecule mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

An integrated platform of genomic assays reveals small-molecule bioactivities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Quantitative phenotyping via deep barcode sequencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Enhancing drug accumulation in Saccharomyces cerevisiae by repression of pleiotropic drug resistance genes with chimeric transcription repressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

shRNA libraries and their use in cancer genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Topoisomerase levels determine chemotherapy responsein vitroandin vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Haploid genetic screens in human cells identify host factors used by pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Forward and reverse genetics through derivation of haploid mouse embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A functional genomics approach to the mode of action of apratoxin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A novel genetic system to detect protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A three-hybrid system for detecting small ligand-protein receptor interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

MASPIT: three-hybrid trap for quantitative proteome fingerprinting of small molecule-protein interactions in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A Coiled-Coil Enabled Split-Luciferase Three-Hybrid System: Applied Toward Profiling Inhibitors of Protein Kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A three-hybrid approach to scanning the proteome for targets of small molecule kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Phage display systems and their applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

In vitro selection from protein and peptide libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Display of expression products of cDNA libraries on phage surfaces. A versatile screening system for selective isolation of genes by specific gene-product/ligand interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Display cloning: functional identification of natural product receptors using cDNA-phage display

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of hNopp140 as a binding partner for doxorubicin with a phage display cloning method

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Screening of a library of phage-displayed peptides identifies human bcl-2 as a taxol-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Screening of paclitaxel-binding molecules from a library of random peptides displayed on T7 phage particles using paclitaxel-photoimmobilized resin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A new curcumin derivative, HBC, interferes with the cell cycle progression of colon cancer cells via antagonization of the Ca2+/calmodulin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

cDNA phage display as a novel tool to screen for cellular targets of chemical compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Rapid identification of a protein binding partner for the marine natural product kahalalide F by using reverse chemical proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Drug receptor identification from multiple tissues using cellular-derived mRNA display libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Luminescent oxygen channeling immunoassay: measurement of particle binding kinetics by chemiluminescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Why molecules move along a temperature gradient

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Label-free microscale thermophoresis discriminates sites and affinity of protein-ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Phosphatidylethanolamine-binding proteins, including RKIP, exhibit affinity for phosphodiesterase-5 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Analysis of Protein−Small Molecule Interactions by Microscale Equilibrium Dialysis and Its Application As a Secondary Confirmation Method for on-Bead Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

An electrochemical sensor for the detection of protein-small molecule interactions directly in serum and other complex matrices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Small-molecule inhibition of APT1 affects Ras localization and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of a small-molecule inhibitor of class Ia PI3Ks with cell-based screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A dumbbell-shaped small molecule that promotes cell adhesion and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Marine antifungal theonellamides target 3beta-hydroxysterol to activate Rho1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Diterpenoids from Isodon adenantha

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Flavinylation of monoamine oxidase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Nucleophosmin is required for chromosome congression, proper mitotic spindle formation, and kinetochore-microtubule attachment in HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Structural view of a fungal toxin acting on a 14-3-3 regulatory complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

The metabolic serine hydrolases and their functions in mammalian physiology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of a primary target of thalidomide teratogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A planning strategy for diversity-oriented synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Pursuing the leadlikeness concept in pharmaceutical research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Distributed Drug Discovery, Part 1: linking academia and combinatorial chemistry to find drug leads for developing world diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Fusicoccin: a New Wilting Toxin produced by Fusicoccum amygdali Del

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

21 January 2018

Identifiers

DOI

10.1002/ANIE.201208749

1 reference

3 August 2017

1 reference