Central tolerance: what have we learned from mice? (Q34600502)

3 August 2017

1 reference

title

Central tolerance: what have we learned from mice? (English)

1 reference

3 August 2017

Kristin A Hogquist

2

0 references

author name string

Tom M McCaughtry

series ordinal

1

1 reference

PubMed ID

19015857

3 August 2017

language of work or name

1 reference

23 October 2008

1 reference

Seminars in Immunopathology

3 August 2017

1 reference

3 August 2017

30

1 reference

3 August 2017

4

1 reference

3 August 2017

399-409

1 reference

https://scigraph.springernature.com/pub.10.1007/s00281-008-0137-0

3 August 2017

0 references

cites work

The fourth way? Harnessing aggressive tendencies in the thymus

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

RasGRP1 transmits prodifferentiation TCR signaling that is crucial for CD4 T cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

Preferential development of CD4 and CD8 T regulatory cells in RasGRP1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

Cutting edge: identification of the targets of clonal deletion in an unmanipulated thymus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of bim [corrected].

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

Characterization of transcriptional regulation during negative selection in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

Induction of tolerance by embryonic thymic epithelial grafts in birds and mammals

21 January 2018

2 references

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

21 January 2018

12 December 2020

Regulation of CD8+ T cell development by thymus-specific proteasomes

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

CCR7 directs the migration of thymocytes into the thymic medulla

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

Dependence of self-tolerance on TRAF6-directed development of thymic stroma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

Developmental alterations in thymocyte sensitivity are actively regulated by MHC class II expression in the thymic medulla

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

A specific anti-Aire antibody reveals aire expression is restricted to medullary thymic epithelial cells and not expressed in periphery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

Two developmentally distinct populations of dendritic cells inhabit the adult mouse thymus: demonstration by differential importation of hematogenous precursors under steady state conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-008-0137-0

Regulation of B- and T-cell differentiation by a single microRNA

21 January 2018

1 reference

12 December 2020

RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

1 reference

12 December 2020

Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla

1 reference

12 December 2020

Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis

1 reference

12 December 2020

Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

1 reference

12 December 2020

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

1 reference

12 December 2020

Generation of NK1.1+ T cell antigen receptor alpha/beta+ thymocytes associated with intact thymic structure

1 reference

12 December 2020

Lymphotoxin beta receptor is required for the migration and selection of autoreactive T cells in thymic medulla

1 reference

12 December 2020

The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

1 reference

12 December 2020

Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype

1 reference

12 December 2020

The timing of TCR alpha expression critically influences T cell development and selection

1 reference

12 December 2020

Thymic emigration revisited

1 reference

12 December 2020

Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands

1 reference

12 December 2020

Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation

1 reference

12 December 2020

Receptor editing in developing T cells

1 reference

12 December 2020

Thymic development and peripheral homeostasis of regulatory T cells.

1 reference

12 December 2020

Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

1 reference

12 December 2020

CCR7 signals are essential for cortex-medulla migration of developing thymocytes.

1 reference

12 December 2020

Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells.

1 reference

12 December 2020

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1 reference

12 December 2020

Nur77 transcription activity correlates with its apoptotic function in vivo

1 reference

12 December 2020

Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion

1 reference

12 December 2020

Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input

1 reference

12 December 2020

A role for accessibility to self-peptide-self-MHC complexes in intrathymic negative selection

1 reference

12 December 2020

Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice

1 reference

12 December 2020

Deletion of high-avidity T cells by thymic epithelium

1 reference

12 December 2020

What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain

1 reference

12 December 2020

TCR signaling regulates thymic organization: lessons from TCR-transgenic mice

1 reference

12 December 2020

Editing autoreactive TCR enables efficient positive selection

1 reference

12 December 2020

Negative selection--clearing out the bad apples from the T-cell repertoire

1 reference

12 December 2020

During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain

1 reference

12 December 2020

Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells

1 reference

12 December 2020

Aire regulates negative selection of organ-specific T cells

1 reference

12 December 2020

Heterogeneity of thymic dendritic cells

1 reference

12 December 2020

Aberrant T cell differentiation in the absence of Dicer.

1 reference

12 December 2020

Negative selection of T cells occurs throughout thymic development

1 reference

12 December 2020

Developmental regulation of Foxp3 expression during ontogeny.

1 reference

12 December 2020

Antigen-specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection

1 reference

12 December 2020

Central tolerance: learning self-control in the thymus

1 reference

12 December 2020

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1 reference

12 December 2020

Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance

1 reference

12 December 2020

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1 reference

12 December 2020

A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection

1 reference

12 December 2020

A role for Dicer in immune regulation

1 reference

12 December 2020

The role of dendritic cells in T cell selection and survival

1 reference

12 December 2020

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

1 reference

12 December 2020

ERK5 is a novel type of mitogen-activated protein kinase containing a transcriptional activation domain

1 reference

12 December 2020

T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes

1 reference

12 December 2020

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1 reference

12 December 2020

CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance

1 reference

12 December 2020

Thymic differentiation of TCR alpha beta(+) CD8 alpha alpha(+) IELs

1 reference

12 December 2020

The cellular mechanism of Aire control of T cell tolerance.

1 reference

12 December 2020

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

1 reference

12 December 2020

The influence of the thymic environment on the CD4-versus-CD8 T lineage decision.

1 reference

12 December 2020

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

1 reference

12 December 2020

Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation

1 reference

12 December 2020

Anergy induced by thymic medullary epithelium

1 reference

12 December 2020

Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

1 reference

12 December 2020

Thymus epithelium induces tissue-specific tolerance

1 reference

12 December 2020

Defective central tolerance induction in NOD mice: genomics and genetics

1 reference

12 December 2020

Antigen-induced apoptosis in developing T cells: a mechanism for negative selection of the T cell receptor repertoire

1 reference

12 December 2020

Tolerogenicity of thymic epithelium

1 reference

12 December 2020

Minor but not major histocompatibility antigens of thymus epithelium tolerize precursors of cytolytic T cells

1 reference

12 December 2020

Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus

1 reference

12 December 2020

Expression of relB is required for the development of thymic medulla and dendritic cells

1 reference

12 December 2020

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

1 reference

12 December 2020

Chromosomal clustering of genes controlled by the aire transcription factor

1 reference

12 December 2020

Thymic epithelium and the induction of transplantation tolerance in nude mice

1 reference

12 December 2020

Spontaneous autoimmunity prevented by thymic expression of a single self-antigen

1 reference

12 December 2020

Thymic cortical epithelium induces self tolerance

1 reference

12 December 2020

A constant affinity threshold for T cell tolerance

1 reference

12 December 2020

In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes

1 reference

12 December 2020

What's new in the Aire?

1 reference

12 December 2020

Dissociation of thymic positive and negative selection in transgenic mice expressing major histocompatibility complex class I molecules exclusively on thymic cortical epithelial cells

1 reference

12 December 2020

Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR.

1 reference

12 December 2020

Regulation of Bim by TCR signals in CD4/CD8 double-positive thymocytes

1 reference

12 December 2020

Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes

1 reference

12 December 2020

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1 reference

12 December 2020

Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation

1 reference

12 December 2020

Transcriptional analysis of clonal deletion in vivo

1 reference

12 December 2020

HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis

1 reference

12 December 2020

Selection of the T-cell repertoire in transgenic mice expressing a transplantation antigen in distinct thymus subsets

1 reference

12 December 2020

Altered thymocyte development resulting from expressing a deleting ligand on selecting thymic epithelium

1 reference

12 December 2020

Development and selection of Valpha l4i NKT cells.

1 reference

12 December 2020

Non-deletional mechanisms of peripheral and central tolerance: studies with transgenic mice with tissue-specific expression of a foreign MHC class I antigen

1 reference

12 December 2020

Generating intrathymic microenvironments to establish T-cell tolerance.

1 reference

12 December 2020

T cell tolerance by clonal elimination in the thymus

1 reference

12 December 2020

Protein phosphatase subunit G5PR that regulates the JNK-mediated apoptosis signal is essential for the survival of CD4 and CD8 double-positive thymocytes

1 reference

12 December 2020

Rapid deletion of rearranged T cell antigen receptor (TCR) Valpha-Jalpha segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR alpha chain gene and positive selection in the T cell repertoire formation.

1 reference

12 December 2020

miR-181a is an intrinsic modulator of T cell sensitivity and selection

1 reference

12 December 2020

Lysosomal cysteine proteases regulate antigen presentation

1 reference

12 December 2020

A central role for peripheral dendritic cells in the induction of acquired thymic tolerance

1 reference

12 December 2020

Thymocyte-dendritic cell interactions near sources of CCR7 ligands in the thymic cortex.

1 reference

12 December 2020

Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling

1 reference

12 December 2020

Positive and negative selection of an antigen receptor on T cells in transgenic mice.

1 reference

12 December 2020

Central tolerance to self-antigen expressed by cortical epithelial cells

1 reference

12 December 2020

Rat Thymic Epithelium Positively Selects Mouse T Cells with Specificity for Rat MHC Class II Antigens but Fails to Induce Detectable Tolerance in the Mouse T Cells to the Rat MHC Antigens

1 reference

12 December 2020

Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing

1 reference

12 December 2020

10.1007/S00281-008-0137-0

Identifiers

DOI

1 reference

PubMed ID

19015857

Dimensions Publication ID

3 August 2017

0 references

1 reference

PubMed ID

19015857