Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia (Q34876825)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25395428%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25395428%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

16

1 reference

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22 February 2020

Gang G Wang

18

1 reference

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22 February 2020

author name string

Bowen Xu

1

1 reference

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22 February 2020

Doan M On

2

1 reference

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22 February 2020

Anqi Ma

3

1 reference

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22 February 2020

Trevor Parton

4

1 reference

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22 February 2020

Kyle D Konze

5

1 reference

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22 February 2020

Samantha G Pattenden

6

1 reference

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22 February 2020

David F Allison

7

1 reference

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22 February 2020

Ling Cai

8

1 reference

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22 February 2020

Shira Rockowitz

9

1 reference

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22 February 2020

Shichong Liu

10

1 reference

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22 February 2020

Ying Liu

11

1 reference

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22 February 2020

Fengling Li

12

1 reference

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22 February 2020

Masoud Vedadi

13

1 reference

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22 February 2020

Stephen V Frye

14

1 reference

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22 February 2020

Benjamin A Garcia

15

1 reference

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22 February 2020

Jian Jin

17

1 reference

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22 February 2020

language of work or name

English

0 references

publication date

13 November 2014

1 reference

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22 February 2020

number of pages

12

1 reference

based on heuristic

inferred from page(s)

published in

Blood

1 reference

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22 February 2020

volume

125

1 reference

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22 February 2020

issue

2

1 reference

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22 February 2020

page(s)

346-357

1 reference

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Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16.

22 February 2020

cites work

1 reference

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Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma

8 July 2018

1 reference

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Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain

8 July 2018

1 reference

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Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations

8 July 2018

1 reference

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Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis.

8 July 2018

1 reference

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Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth

8 July 2018

1 reference

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Chromatin proteins and modifications as drug targets

8 July 2018

1 reference

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Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer

8 July 2018

1 reference

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DZNep, inhibitor of S-adenosylhomocysteine hydrolase, down-regulates expression of SETDB1 H3K9me3 HMTase in human lung cancer cells

8 July 2018

1 reference

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EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

8 July 2018

1 reference

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Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.

8 July 2018

1 reference

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An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting

8 July 2018

1 reference

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Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

8 July 2018

1 reference

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

8 July 2018

1 reference

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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

8 July 2018

1 reference

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Examining histone posttranslational modification patterns by high-resolution mass spectrometry

8 July 2018

1 reference

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The role of mutations in epigenetic regulators in myeloid malignancies

8 July 2018

1 reference

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Cancer epigenetics: from mechanism to therapy

8 July 2018

1 reference

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Epigenetic protein families: a new frontier for drug discovery

8 July 2018

1 reference

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Histone methylation: a dynamic mark in health, disease and inheritance

8 July 2018

1 reference

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The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.

8 July 2018

1 reference

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Polycomb repressive complex 2 is required for MLL-AF9 leukemia

8 July 2018

1 reference

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

The Polycomb complex PRC2 and its mark in life

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

8 July 2018

1 reference

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Selective inhibition of BET bromodomains

8 July 2018

1 reference

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Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers

8 July 2018

1 reference

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Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines

8 July 2018

1 reference

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Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes

8 July 2018

1 reference

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Distinct factors control histone variant H3.3 localization at specific genomic regions

8 July 2018

1 reference

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Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36

8 July 2018

1 reference

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

8 July 2018

1 reference

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The molecular biology of mixed lineage leukemia

8 July 2018

1 reference

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DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

MLL translocations, histone modifications and leukaemia stem-cell development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

Chromatin immunoprecipitation and microarray-based analysis of protein location

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

Cancer epigenomics: DNA methylomes and histone-modification maps

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

The language of covalent histone modifications

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287641

Switching on epigenetic therapy

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25395428

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ezh1 Is Required for Hematopoietic Stem Cell Maintenance and Prevents Senescence-like Cell Cycle Arrest

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25395428

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2014-06-581082

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25395428%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25395428%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

PubMed publication ID

25395428

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25395428%20AND%20SRC:MED&resulttype=core&format=json