The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics. (Q34947846)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21367866%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics (English)

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24 January 2020

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4

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24 January 2020

Lisa Lawson

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24 January 2020

J R Jones

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Edwin J Weeber

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24 January 2020

author name string

Umesh K Jinwal

1

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24 January 2020

Justin H Trotter

2

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24 January 2020

Jose F Abisambra

3

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24 January 2020

Grant D Vestal

6

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24 January 2020

John C O'Leary

7

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24 January 2020

Amelia G Johnson

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24 January 2020

Ying Jin

9

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24 January 2020

Qingyou Li

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24 January 2020

Chad A Dickey

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24 January 2020

language of work or name

English

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publication date

2 March 2011

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Journal of Biological Chemistry

24 January 2020

published in

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24 January 2020

volume

286

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24 January 2020

issue

19

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24 January 2020

page(s)

16976-16983

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GSK3 signalling in neural development

24 January 2020

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The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.

8 July 2018

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Structural polymorphism of 441-residue tau at single residue resolution

8 July 2018

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The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail

8 July 2018

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Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors

8 July 2018

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Akt and CHIP coregulate tau degradation through coordinated interactions

8 July 2018

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Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

8 July 2018

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

8 July 2018

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The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

8 July 2018

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Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Separation of phosphoprotein isotypes having the same number of phosphate groups using phosphate-affinity SDS-PAGE.

8 July 2018

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HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites

21 January 2018

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Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

21 January 2018

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Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

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Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

21 January 2018

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Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease.

21 January 2018

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21 January 2018

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26 October 2018

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26 October 2018

Identifiers

DOI

10.1074/JBC.M110.182493

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21367866%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

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24 January 2020

1 reference