Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet (Q35080619)

6 August 2017

Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet (English)

1 reference

6 August 2017

0 references

0 references

1 reference

3

Mikhail V Blagosklonny

1 reference

6 August 2017

Olga V Leontieva

1

1 reference

PubMed ID

24655348

6 August 2017

Geraldine M Paszkiewicz

series ordinal

2

1 reference

6 August 2017

22 March 2014

1 reference

6 August 2017

1 reference

6 August 2017

13

1 reference

6 August 2017

4

1 reference

6 August 2017

616-622

1 reference

Dysregulation of the mTOR pathway in p53-deficient mice

6 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Metformin improves healthspan and lifespan in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Rapamycin extends murine lifespan but has limited effects on aging

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

MEK drives cyclin D1 hyperelevation during geroconversion

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Late-life rapamycin treatment reverses age-related heart dysfunction.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Rapamycin extends life and health in C57BL/6 mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

GSK-3α is a central regulator of age-related pathologies in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

mTOR is a key modulator of ageing and age-related disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

mTOR in aging, metabolism, and cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Hypoxia suppresses conversion from proliferative arrest to cellular senescence

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Rapamycin slows aging in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

A longer and healthier life with TOR down-regulation: genetics and drugs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

mTOR: from growth signal integration to cancer, diabetes and ageing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Paradoxical suppression of cellular senescence by p53

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Rapamycin extends maximal lifespan in cancer-prone mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Growth and aging: a common molecular mechanism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

The TOR pathway comes of age

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326934

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

8 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12211

Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12211

Chronic Akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12211

A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12211

The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24655348

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Rapamycin slows aging in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24655348

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/ACEL.12211

1 reference

6 August 2017

1 reference

6 August 2017

1 reference

PubMed ID

24655348