Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1) (Q35642456)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1) (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

Paola Giusti-Rodríguez

1

1 reference

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15 January 2020

Johannes Gräff

3

1 reference

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15 January 2020

Takahiro Soda

5

1 reference

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15 January 2020

6

Li-Huei Tsai

1 reference

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15 January 2020

author name string

Jun Gao

2

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15 January 2020

Damien Rei

4

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15 January 2020

language of work or name

English

0 references

publication date

1 November 2011

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15 January 2020

published in

Journal of Neuroscience

1 reference

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15 January 2020

volume

31

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15 January 2020

issue

44

1 reference

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15 January 2020

page(s)

15751-15756

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Reduced sodium channel Na(v)1.1 levels in BACE1-null mice

15 January 2020

cites work

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12 July 2018

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Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex.

12 July 2018

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12 July 2018

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Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity

12 July 2018

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12 July 2018

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Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

12 July 2018

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12 July 2018

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Recovery of learning and memory is associated with chromatin remodelling

12 July 2018

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Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

12 July 2018

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BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

12 July 2018

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12 July 2018

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BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

12 July 2018

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Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation

12 July 2018

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Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death

12 July 2018

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Gene regulation and DNA damage in the ageing human brain

12 July 2018

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Pathology of presynaptic proteins in Alzheimer's disease: more than simple loss of terminals.

12 July 2018

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Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

12 July 2018

1 reference

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Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors

12 July 2018

1 reference

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Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced Apoptosis

12 July 2018

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Alzheimer's disease is a synaptic failure

12 July 2018

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Cyclin-dependent kinase 5 is required for associative learning

12 July 2018

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Acute cholinergic rescue of synaptic plasticity in the neurodegenerating cortex of anti-nerve-growth-factor mice.

12 July 2018

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Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

12 July 2018

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12 July 2018

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p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment

12 July 2018

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Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

12 July 2018

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

12 July 2018

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Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice

12 July 2018

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Neurotoxicity induces cleavage of p35 to p25 by calpain

12 July 2018

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

12 July 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

12 July 2018

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A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease.

12 July 2018

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12 July 2018

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12 July 2018

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CDK5 serves as a major control point in neurotransmitter release.

25 September 2018

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In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

25 September 2018

1 reference

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Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease.

25 September 2018

1 reference

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p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248793

Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248793

Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2.

25 September 2018

1 reference

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BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248793

Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248793

Insulin-like growth factor-I improves cerebellar dysfunction but does not prevent cerebellar neurodegeneration in the calcium channel mutant mouse, leaner

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22049418

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

p25/cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22049418

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1523/JNEUROSCI.3588-11.2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

22049418

1 reference