Dynamic ligand-induced conformational rearrangements in P-glycoprotein as probed by fluorescence resonance energy transfer spectroscopy (Q35668939)

9 August 2017

title

Dynamic ligand-induced conformational rearrangements in P-glycoprotein as probed by fluorescence resonance energy transfer spectroscopy (English)

1 reference

9 August 2017

0 references

Michael Börsch

3

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author name string

Brandy Verhalen

series ordinal

1

1 reference

9 August 2017

Stefan Ernst

series ordinal

2

1 reference

9 August 2017

Stephan Wilkens

series ordinal

4

1 reference

9 August 2017

language of work or name

English

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publication date

15 November 2011

1 reference

Journal of Biological Chemistry

9 August 2017

published in

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9 August 2017

volume

287

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9 August 2017

issue

2

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9 August 2017

page(s)

1112-1127

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Reaction chemistry ABC-style

9 August 2017

cites work

1 reference

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Molecular-dynamics simulations of the ATP/apo state of a multidrug ATP-binding cassette transporter provide a structural and mechanistic basis for the asymmetric occluded state

27 July 2018

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P-glycoprotein retains drug-stimulated ATPase activity upon covalent linkage of the two nucleotide binding domains at their C-terminal ends

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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The remarkable transport mechanism of P-glycoprotein: a multidrug transporter

27 July 2018

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27 July 2018

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27 July 2018

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ATP hydrolysis is required to reset the ATP-binding cassette dimer into the resting-state conformation

27 July 2018

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27 July 2018

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Movements of the epsilon-subunit during catalysis and activation in single membrane-bound H(+)-ATP synthase

27 July 2018

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Interaction of LDS-751 with P-glycoprotein and mapping of the location of the R drug binding site.

27 July 2018

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Fluorescence-aided molecule sorting: analysis of structure and interactions by alternating-laser excitation of single molecules

27 July 2018

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A Tweezers-like Motion of the ATP-Binding Cassette Dimer in an ABC Transport Cycle

27 July 2018

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FRET or no FRET: a quantitative comparison

27 July 2018

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Transition state P-glycoprotein binds drugs and modulators with unchanged affinity, suggesting a concerted transport mechanism.

27 July 2018

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Applications of novel resonance energy transfer techniques to study dynamic hormone receptor interactions in living cells.

27 July 2018

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Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains.

27 July 2018

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ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

27 July 2018

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Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes

27 July 2018

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Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

27 July 2018

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Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

27 July 2018

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27 July 2018

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P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site

27 July 2018

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Energy transfer: a spectroscopic ruler

27 July 2018

1 reference

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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

27 July 2018

1 reference

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Human P-glycoprotein is active when the two halves are clamped together in the closed conformation

27 July 2018

1 reference

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Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

25 September 2018

1 reference

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ABC transporters: the power to change

25 September 2018

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The proton-translocating a subunit of F0F1-ATP synthase is allocated asymmetrically to the peripheral stalk

25 September 2018

1 reference

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Nucleotide-induced structural changes in P-glycoprotein observed by electron microscopy.

25 September 2018

1 reference

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Flexibility in the ABC transporter MsbA: Alternating access with a twist

25 September 2018

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Catalytic cycle of ATP hydrolysis by P-glycoprotein: evidence for formation of the E.S reaction intermediate with ATP-gamma-S, a nonhydrolyzable analogue of ATP.

25 September 2018

1 reference

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Expression, purification, and characterization of cysteine-free mouse P-glycoprotein

25 September 2018

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Nucleotide binding to the multidrug resistance P-glycoprotein as studied by ESR spectroscopy

25 September 2018

1 reference

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Properties of P-glycoprotein with mutations in the "catalytic carboxylate" glutamate residues

25 September 2018

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Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256922

P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state

25 September 2018

1 reference

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Stoichiometry and affinity of nucleotide binding to P-glycoprotein during the catalytic cycle

25 September 2018

1 reference

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The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256922

Stepwise rotation of the gamma-subunit of EF(0)F(1)-ATP synthase observed by intramolecular single-molecule fluorescence resonance energy transfer

25 September 2018

1 reference

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Projection structure of P-glycoprotein by electron microscopy. Evidence for a closed conformation of the nucleotide binding domains

25 September 2018

1 reference

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Multidrug resistance in cancer: role of ATP-dependent transporters

25 September 2018

1 reference

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25 September 2018

1 reference

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Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256922

Large scale purification of detergent-soluble P-glycoprotein from Pichia pastoris cells and characterization of nucleotide binding properties of wild-type, Walker A, and Walker B mutant proteins.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256922

ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256922

Proximity of the nucleotide binding domains of the P-glycoprotein multidrug transporter to the membrane surface: a resonance energy transfer study.

25 September 2018

1 reference

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Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256922

Maximum likelihood trajectories from single molecule fluorescence resonance energy transfer experiments

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M111.301192

Inhibition of P-glycoprotein ATPase activity by beryllium fluoride

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22086917

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

High-level expression of mouse Mdr3 P-glycoprotein in yeast Pichia pastoris and characterization of ATPase activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22086917

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M111.301192

1 reference

9 August 2017

1 reference

9 August 2017

1 reference