Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak. (Q35748569)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056880%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak (English)

1 reference

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16 January 2020

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1

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16 January 2020

author name string

R J Youle

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056880%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

language of work or name

English

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publication date

7 November 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056880%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056880%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

volume

31

1 reference

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16 January 2020

issue

26

1 reference

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16 January 2020

page(s)

3177-3189

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Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

16 January 2020

cites work

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12 July 2018

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Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma.

12 July 2018

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A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

12 July 2018

1 reference

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Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1.

12 July 2018

1 reference

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Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis

12 July 2018

1 reference

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Surprising complexity of the ancestral apoptosis network

12 July 2018

1 reference

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Activation of the mitochondrial death pathway is commonly mediated by a preferential engagement of Bak.

12 July 2018

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NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition

12 July 2018

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

12 July 2018

1 reference

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

12 July 2018

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

12 July 2018

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Improved methods for the generation of human gene knockout and knockin cell lines

12 July 2018

1 reference

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

12 July 2018

1 reference

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Bax-dependent regulation of Bak by voltage-dependent anion channel 2.

12 July 2018

1 reference

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

12 July 2018

1 reference

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Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway

12 July 2018

1 reference

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Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses

12 July 2018

1 reference

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Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway

12 July 2018

1 reference

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Nonredundant role of Bax and Bak in Bid-mediated apoptosis

12 July 2018

1 reference

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Critical requirement of BAX for manifestation of apoptosis induced by multiple stimuli in human epithelial cancer cells.

12 July 2018

1 reference

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Bax and Bak independently promote cytochrome C release from mitochondria

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276724

TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.

12 July 2018

1 reference

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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276724

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276724

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276724

Role of BAX in the apoptotic response to anticancer agents

12 July 2018

1 reference

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Bak and Bax are non-redundant during infection- and DNA damage-induced apoptosis

12 July 2018

1 reference

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Functional characterization of the Bcl-2 gene family in the zebrafish.

25 September 2018

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Highly conserved caspase and Bcl-2 homologues from the sea anemone Aiptasia pallida: lower metazoans as models for the study of apoptosis evolution

25 September 2018

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Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.

25 September 2018

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Cisplatin-induced apoptosis in p53-deficient renal cells via the intrinsic mitochondrial pathway

25 September 2018

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Crossref

https://api.crossref.org/works/10.1038%2FONC.2011.497

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2011.497

Bak but not Bax is essential for Bcl-xS-induced apoptosis

31 March 2020

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2011.497

Antitumor activity and bystander effects of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22056880

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2011.497

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056880%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22056880%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

22056880

1 reference