Phosphorylation of IRS proteins Yin-Yang regulation of insulin signaling (Q37403974)

20 August 2017

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title

Phosphorylation of IRS proteins Yin-Yang regulation of insulin signaling (English)

1 reference

20 August 2017

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1 reference

Xiao Jian Sun

1

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PubMed ID

19251044

20 August 2017

Feng Liu

series ordinal

2

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20 August 2017

1 January 2009

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20 August 2017

Vitamins and Hormones

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20 August 2017

80

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20 August 2017

351-387

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The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

20 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Different subcellular distribution and regulation of expression of insulin receptor substrate (IRS)-3 from those of IRS-1 and IRS-2

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

IKK-beta links inflammation to obesity-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

New clues to how proteins link up to run the cell.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Role of brain insulin receptor in control of body weight and reproduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Two New Substrates in Insulin Signaling, IRS5/DOK4 and IRS6/DOK5

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Phosphatidylinositol 3'-kinase associates with an insulin receptor substrate-1 serine kinase distinct from its intrinsic serine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Mammalian MAP kinase signalling cascades

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Stat5 is a physiological substrate of the insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Functional significance of type 1 insulin-like growth factor-mediated nuclear translocation of the insulin receptor substrate-1 and beta-catenin.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Intracellular localization of phosphatidylinositide 3-kinase and insulin receptor substrate-1 in adipocytes: potential involvement of a membrane skeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Characterization of a novel member of the DOK family that binds and modulates Abl signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

PDZ proteins organize synaptic signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Molecular actions of insulin on glucose transport

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin response in skeletal muscle and fat cells of the genetically obese Zucker rat

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Physiological roles of PKB/Akt isoforms in development and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

The FHA domain is a modular phosphopeptide recognition motif.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

The molecular basis for oxidative stress-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Cloning, tissue expression, and chromosomal location of the mouse insulin receptor substrate 4 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Signaling pathways: the benefits of good communication

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

The PI3-kinase serine kinase phosphorylates its p85 subunit and IRS-1 in PI3-kinase/IRS-1 complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Reactive species and early manifestation of insulin resistance in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Impaired glucose transport and insulin receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Role of Rho-kinase in regulation of insulin action and glucose homeostasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

PH domain: the first anniversary

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Phosphorylation of Irs1 at SER-522 inhibits insulin signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

PKCdelta-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

A central role for JNK in obesity and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Inflammatory pathways and insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Reactive oxygen species have a causal role in multiple forms of insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Metabolic stress signaling mediated by mixed-lineage kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Prevention of fat-induced insulin resistance by salicylate

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

PKC-theta knockout mice are protected from fat-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute [...]

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Interleukin-6 depletion selectively improves hepatic insulin action in obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

14-3-3beta protein associates with insulin receptor substrate 1 and decreases insulin-stimulated phosphatidylinositol 3'-kinase activity in 3T3L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Dynamics of signaling during insulin-stimulated endocytosis of its receptor in adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin receptor substrate 1 translocation to the nucleus by the human JC virus T-antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin receptor substrate 3 is not essential for growth or glucose homeostasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Function of WW domains as phosphoserine- or phosphothreonine-binding modules

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Modulation of vascular smooth muscle signaling by reactive oxygen species

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Structure of the pleckstrin homology domain from beta-spectrin.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in Fao hepatoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Identification of the APS protein as a novel insulin receptor substrate

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

14-3-3: modulators of signaling proteins?

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

The PH domain: a common piece in the structural patchwork of signalling proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Role of IRS-1-GRB-2 complexes in insulin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Redox regulation of cellular activation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Modulation of the JNK pathway in liver affects insulin resistance status

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Nutrient sensor links obesity with diabetes risk

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Protein modules and signalling networks

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Isolation of a src homology 2-containing tyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Nuclear translocation of insulin receptor substrate-1 by the simian virus 40 T antigen and the activated type 1 insulin-like growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Identification of enhanced serine kinase activity in insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

1 reference

7 January 2021

Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Specific protein kinase C isoforms as transducers and modulators of insulin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Disordered lipid metabolism and the pathogenesis of insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Protein kinase C and lipid-induced insulin resistance in skeletal muscle.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Interleukin-6 induces cellular insulin resistance in hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Inflammation and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Obesity, Inflammation, and Insulin Resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

PTEN expression causes feedback upregulation of insulin receptor substrate 2

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

The insulin receptor substrate (IRS-1) is a PEST protein that is susceptible to calpain degradation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Ceramides in insulin resistance and lipotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

A role for sphingolipids in producing the common features of type 2 diabetes, metabolic syndrome X, and Cushing's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Role of IRS-2 in insulin and cytokine signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin-like growth factor I receptor signaling and nuclear translocation of insulin receptor substrates 1 and 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

PTB domain of insulin receptor substrate-1 binds inositol compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

A carboxy-terminal truncated insulin receptor substrate-1 dominant negative protein reverses the human hepatocellular carcinoma malignant phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Critical nodes in signalling pathways: insights into insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Tissue-specific roles of IRS proteins in insulin signaling and glucose transport

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

T-antigen of the human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS-1 and Rad51

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Stress, the endoplasmic reticulum, and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

The IRS-signalling system in insulin and cytokine action

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

IRS proteins and the common path to diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Nuclear translocation of insulin receptor substrate-1 by the insulin receptor in mouse embryo fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Grabbing phosphoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Identification of phosphorylation sites in insulin receptor substrate-1 by hypothesis-driven high-performance liquid chromatography-electrospray ionization tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900613-4

7 January 2021

10.1016/S0083-6729(08)00613-4

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19251044