The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro (Q35860523)

10 August 2017

The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro (English)

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10 August 2017

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11 June 2020

author name string

Marc N Wein

2

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11 June 2020

Jonathan H Gooi

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11 June 2020

Yili Qu

4

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11 June 2020

Jenna L Garr

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11 June 2020

Shawn Liu

6

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11 June 2020

Kevin J Barry

7

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11 June 2020

Yuhei Uda

8

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11 June 2020

Forest Lai

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11 June 2020

Christopher Dedic

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11 June 2020

Mercedes Balcells-Camps

11

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11 June 2020

Henry M Kronenberg

12

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11 June 2020

Philip Babij

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11 June 2020

Paola Divieti Pajevic

14

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11 June 2020

language of work or name

English

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publication date

7 May 2015

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Journal of Biological Chemistry

10 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25953900%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

290

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11 June 2020

issue

27

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11 June 2020

page(s)

16744-16758

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HDAC5 controls MEF2C-driven sclerostin expression in osteocytes

11 June 2020

cites work

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Pax6 expressed in osteocytes inhibits canonical Wnt signaling

11 July 2018

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Load regulates bone formation and Sclerostin expression through a TGFβ-dependent mechanism

11 July 2018

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Amphiregulin-EGFR signaling mediates the migration of bone marrow mesenchymal progenitors toward PTH-stimulated osteoblasts and osteocytes

11 July 2018

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Bariatric surgery results in cortical bone loss

11 July 2018

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Space flight calcium: implications for astronaut health, spacecraft operations, and Earth

11 July 2018

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Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling

11 July 2018

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Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading

11 July 2018

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Numerical simulation of fluid field and in vitro three-dimensional fabrication of tissue-engineered bones in a rotating bioreactor and in vivo implantation for repairing segmental bone defects

11 July 2018

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Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin

11 July 2018

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Serum sclerostin increases in healthy adult men during bed rest.

11 July 2018

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Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.

11 July 2018

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Weight loss in obese older adults increases serum sclerostin and impairs hip geometry but both are prevented by exercise training

11 July 2018

1 reference

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TGF-β regulates sclerostin expression via the ECR5 enhancer

11 July 2018

1 reference

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Effect of oscillating fluid flow stimulation on osteocyte mRNA expression

11 July 2018

1 reference

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Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading.

11 July 2018

1 reference

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Association between sclerostin and bone density in chronic spinal cord injury

11 July 2018

1 reference

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Circulating sclerostin in disorders of parathyroid gland function

11 July 2018

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Evidence for osteocyte regulation of bone homeostasis through RANKL expression

11 July 2018

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Matrix-embedded cells control osteoclast formation

11 July 2018

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Sclerostin expression is induced by BMPs in human Saos-2 osteosarcoma cells but not via direct effects on the sclerostin gene promoter or ECR5 element

11 July 2018

1 reference

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Acute decline in serum sclerostin in response to PTH infusion in healthy men.

11 July 2018

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Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice.

11 July 2018

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Cell line IDG-SW3 replicates osteoblast-to-late-osteocyte differentiation in vitro and accelerates bone formation in vivo

11 July 2018

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Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

11 July 2018

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Increased PTH and 1.25(OH)(2)D levels associated with increased markers of bone turnover following bariatric surgery

11 July 2018

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Mouse Rankl expression is regulated in T cells by c-Fos through a cluster of distal regulatory enhancers designated the T cell control region

11 July 2018

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Prostaglandin E2 signals through PTGER2 to regulate sclerostin expression

11 July 2018

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Keratocan is expressed by osteoblasts and can modulate osteogenic differentiation

11 July 2018

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Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses

11 July 2018

1 reference

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Sclerostin is a direct target of osteoblast-specific transcription factor osterix

11 July 2018

1 reference

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Sclerostin: a gem from the genome leads to bone-building antibodies

11 July 2018

1 reference

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Biological underpinnings of Frost's mechanostat thresholds: the important role of osteocytes

11 July 2018

1 reference

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Modulation of sclerostin expression by mechanical loading and bone morphogenetic proteins in osteogenic cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity

11 July 2018

1 reference

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Boning up on Wolff's Law: mechanical regulation of the cells that make and maintain bone

11 July 2018

1 reference

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Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice

11 July 2018

1 reference

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Identification of differentially expressed genes between osteoblasts and osteocytes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Global transcriptome analysis in mouse calvarial osteoblasts highlights sets of genes regulated by modeled microgravity and identifies a "mechanoresponsive osteoblast gene signature".

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Control of bone mass and remodeling by PTH receptor signaling in osteocytes

11 July 2018

1 reference

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The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression.

11 July 2018

1 reference

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Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Control of the SOST bone enhancer by PTH using MEF2 transcription factors

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Skeletal responses to space flight and the bed rest analog: a review

11 July 2018

1 reference

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MEF2C transcription factor controls chondrocyte hypertrophy and bone development

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Changes in gene expression and signal transduction in microgravity.

11 July 2018

1 reference

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Optimized suspension culture: the rotating-wall vessel

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Immobilization hypercalcemia treatment with pamidronate disodium after spinal cord injury

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Establishment and characterization of an osteocyte-like cell line, MLO-Y4.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Establishment of optimized in vitro assay methods for evaluating osteocyte functions.

11 July 2018

1 reference

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Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Skeletal effects of long-duration head-down bed rest

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Dietary support of long-duration head-down bed rest

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Human primary osteocyte differentiation in a 3D culture system.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Effects of mechanical strain on the function of Gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Ultrastructural changes in osteocytes in microgravity conditions

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505423

Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction

24 September 2018

1 reference

12 December 2020

Changes in serum concentrations of calcium and its regulating hormones during tail suspension in rats

1 reference

12 December 2020

Paradoxical Sost gene expression response to mechanical unloading in metaphyseal bone

1 reference

12 December 2020

Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss

1 reference

12 December 2020

Evaluation of bone mineral density loss in morbidly obese women after gastric bypass: 3-year follow-up

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12 December 2020

Identifiers

DOI

10.1074/JBC.M114.628313

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25953900%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25953900%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

PubMed publication ID

25953900

1 reference