MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5 (Q35912612)

11 August 2017

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5 (English)

1 reference

11 August 2017

Chunxin Wang

2

0 references

Richard J. Youle

series ordinal

4

object named as

Richard J Youle

1 reference

11 August 2017

3

Adam I Fogel

1 reference

11 August 2017

1

Catherine L Nezich

1 reference

PMCID

4523611

11 August 2017

language of work or name

English

0 references

publication date

1 August 2015

1 reference

11 August 2017

Journal of Cell Biology

1 reference

11 August 2017

210

1 reference

11 August 2017

3

1 reference

11 August 2017

435-450

1 reference

PMCID

4523611

describes a project that uses

11 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4523611/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.

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Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter

11 July 2018

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Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

11 July 2018

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Genome-wide screen identifies signaling pathways that regulate autophagy during Caenorhabditis elegans development

11 July 2018

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Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins

11 July 2018

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Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

11 July 2018

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Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis

11 July 2018

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The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris

11 July 2018

1 reference

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PINK1 is degraded through the N-end rule pathway

11 July 2018

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TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity

11 July 2018

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Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease

11 July 2018

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A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts

11 July 2018

1 reference

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Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

11 July 2018

1 reference

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Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes

11 July 2018

1 reference

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Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion.

11 July 2018

1 reference

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RNA-guided human genome engineering via Cas9

11 July 2018

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Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

11 July 2018

1 reference

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PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

11 July 2018

1 reference

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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

11 July 2018

1 reference

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Transcriptional activation of lysosomal exocytosis promotes cellular clearance

11 July 2018

1 reference

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A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery

11 July 2018

1 reference

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Post-translational modification of 14-3-3 isoforms and regulation of cellular function

11 July 2018

1 reference

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Regulation of TFEB and V-ATPases by mTORC1.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

TFEB links autophagy to lysosomal biogenesis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

11 July 2018

1 reference

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

11 July 2018

1 reference

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Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

11 July 2018

1 reference

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Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

11 July 2018

1 reference

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Crude subcellular fractionation of cultured mammalian cell lines

11 July 2018

1 reference

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PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

11 July 2018

1 reference

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Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.

11 July 2018

1 reference

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A gene network regulating lysosomal biogenesis and function

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

14-3-3 proteins: a family of versatile molecular regulators.

11 July 2018

1 reference

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FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

AMPK phosphorylation of raptor mediates a metabolic checkpoint

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Mitochondrial disorders in the nervous system

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

11 July 2018

1 reference

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

PINK1 mutations are associated with sporadic early-onset parkinsonism

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

TSC2 mediates cellular energy response to control cell growth and survival

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Mammalian TOR: a homeostatic ATP sensor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Association between early-onset Parkinson's disease and mutations in the parkin gene

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Targeting the microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E-box elements in vitro and in vivo

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Critical phosphorylation sites for acetyl-CoA carboxylase activity.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Control of p70 s6 kinase by kinase activity of FRAP in vivo

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Regulation of intracellular acetyl-CoA carboxylase by ATP depletors mimics the action of the 5'-AMP-activated protein kinase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

CCCP induces autophagy in an AMPK-independent manner.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Alterations in the common fragile site gene Parkin in ovarian and other cancers

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4523611

microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26240184

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

TFEB regulates lysosomal proteostasis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26240184

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.201501002

1 reference

11 August 2017

1 reference

11 August 2017

1 reference

PMCID

4523611