Mdm2 in growth signaling and cancer (Q36294472)

13 August 2017

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title

Mdm2 in growth signaling and cancer (English)

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13 August 2017

Yaara Levav-Cohen

1

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13 August 2017

Sue Haupt

series ordinal

2

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13 August 2017

Ygal Haupt

series ordinal

3

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13 August 2017

publication date

1 September 2005

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13 August 2017

published in

Growth Factors Journal

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13 August 2017

volume

23

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13 August 2017

issue

3

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13 August 2017

page(s)

183-192

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Phosphorylation of HDM2 by Akt.

13 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Chk1 and Chk2 kinases in checkpoint control and cancer

21 January 2018

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https://api.crossref.org/works/10.1080%2F08977190500196218

Different sensitivity of the transforming growth factor-beta cell cycle arrest pathway to c-Myc and MDM-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology

21 January 2018

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https://api.crossref.org/works/10.1080%2F08977190500196218

Transcriptional regulation of AKT activation by E2F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

E2F1 pathways to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Chalcones: an update on cytotoxic and chemoprotective properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

The "Gab" in signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Specificity in the activation and control of transcription factor E2F-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

MDM2 splice variants and their therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Manipulation of the tumor suppressor p53 for potentiating cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

MdmX inhibits Smad transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Estrogen receptor-dependent proteasomal degradation of the glucocorticoid receptor is coupled to an increase in mdm2 protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Apoptotic and growth-promoting activity of E2F modulated by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Mdmx and Mdm2: brothers in arms?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Transcriptional complexes engaged by apo-estrogen receptor-alpha isoforms have divergent outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

The p53-Mdm2 module and the ubiquitin system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

The MDM2 gene amplification database

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

MDM2--master regulator of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Cyclin G recruits PP2A to dephosphorylate Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Physiological and pathological consequences of the interactions of the p53 tumor suppressor with the glucocorticoid, androgen, and estrogen receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Induction of Mdm2 and enhancement of cell survival by bFGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine-PNA (peptide nucleic acid) conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

p53-independent role of MDM2 in TGF-beta1 resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Repression of p53-mediated transcription by MDM2: a dual mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

BCR/ABL activates mdm2 mRNA translation via the La antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

TGF-beta signaling: positive and negative effects on tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Experimental therapy of human prostate cancer by inhibiting MDM2 expression with novel mixed-backbone antisense oligonucleotides: in vitro and in vivo activities and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

HDM2 phosphorylation by MAPKAP kinase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

The functional interactions between the p53 and MAPK signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Novel antisense anti-MDM2 mixed-backbone oligonucleotides: proof of principle, in vitro and in vivo activities, and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Radiosensitization by antisense anti-MDM2 mixed-backbone oligonucleotide in in vitro and in vivo human cancer models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

Treatment of Chronic Myeloid Leukemia Cells with Imatinib (STI571) Impairs p53 Accumulation in Response to DNA Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190500196218

10.1080/08977190500196218

21 January 2018

Identifiers

DOI

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13 August 2017

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