Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration (Q36326891)

13 August 2017

1 reference

title

Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration (English)

1 reference

13 August 2017

0 references

1 reference

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26026469%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

Parameswaran G Sreekumar

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26026469%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

David R Hinton

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26026469%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

language of work or name

English

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publication date

27 May 2015

1 reference

13 August 2017

11

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Biochimica et Biophysica Acta

inferred from page(s)

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26026469%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

1860

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26026469%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

page(s)

258-268

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26026469%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

issue

1 Pt B

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26026469%20AND%20SRC:MED&resulttype=core&format=json

Emerging role for αB-crystallin as a therapeutic agent: pros and cons

12 June 2020

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30 September 2017

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30 September 2017

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Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

30 September 2017

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Role of α-crystallin B as a regulatory switch in modulating cardiomyocyte apoptosis by mitochondria or endoplasmic reticulum during cardiac hypertrophy and myocardial infarction.

30 September 2017

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Antiapoptotic properties of α-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells

30 September 2017

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Chaperone peptides of α-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts

30 September 2017

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Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization.

30 September 2017

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αB-crystallin regulates oxidative stress-induced apoptosis in cardiac H9c2 cells via the PI3K/AKT pathway

30 September 2017

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Cytoplasmic and nuclear anti-apoptotic roles of αB-crystallin in retinal pigment epithelial cells

30 September 2017

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Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis

30 September 2017

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30 September 2017

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Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction

30 September 2017

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Novel roles for α-crystallins in retinal function and disease

30 September 2017

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X-box binding protein 1 is essential for the anti-oxidant defense and cell survival in the retinal pigment epithelium

30 September 2017

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αB-crystallin/sHSP protects cytochrome c and mitochondrial function against oxidative stress in lens and retinal cells

30 September 2017

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Small heat shock protein αA-crystallin prevents photoreceptor degeneration in experimental autoimmune uveitis

30 September 2017

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Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux

30 September 2017

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30 September 2017

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Therapeutic effects of systemic administration of chaperone αB-crystallin associated with binding proinflammatory plasma proteins

30 September 2017

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30 September 2017

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30 September 2017

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αB-crystallin improves murine cardiac function and attenuates apoptosis in human endothelial cells exposed to ischemia-reperfusion

30 September 2017

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30 September 2017

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Functional rescue of experimental ischemic optic neuropathy with αB-crystallin

30 September 2017

1 reference

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Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat.

30 September 2017

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AlphaB-crystallin is found in detergent-resistant membrane microdomains and is secreted via exosomes from human retinal pigment epithelial cells

30 September 2017

1 reference

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αB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells

30 September 2017

1 reference

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Pathways for cytokine secretion.

30 September 2017

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Emerging applications of stimuli-responsive polymer materials

30 September 2017

1 reference

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alphaB-crystallin regulation of angiogenesis by modulation of VEGF.

30 September 2017

1 reference

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Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Superoxide dismutase-loaded PLGA nanoparticles protect cultured human neurons under oxidative stress

30 September 2017

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Urinary exosomal transcription factors, a new class of biomarkers for renal disease.

30 September 2017

1 reference

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Autophagy fights disease through cellular self-digestion

30 September 2017

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Isolation and characterization of exosomes from cell culture supernatants and biological fluids

30 September 2017

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alphaB-crystallin protects retinal tissue during Staphylococcus aureus-induced endophthalmitis

30 September 2017

1 reference

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Oxidative damage-induced inflammation initiates age-related macular degeneration.

30 September 2017

1 reference

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Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia

30 September 2017

1 reference

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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

30 September 2017

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alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress

30 September 2017

1 reference

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Small heat shock protein alphaB-crystallin binds to p53 to sequester its translocation to mitochondria during hydrogen peroxide-induced apoptosis

30 September 2017

1 reference

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Crystallins in the eye: Function and pathology

30 September 2017

1 reference

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Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Exosomal Fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury

30 September 2017

1 reference

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Mini-alphaB-crystallin: a functional element of alphaB-crystallin with chaperone-like activity

30 September 2017

1 reference

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AlphaB-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer

30 September 2017

1 reference

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Heat shock pretreatment inhibited the release of Smac/DIABLO from mitochondria and apoptosis induced by hydrogen peroxide in cardiomyocytes and C2C12 myogenic cells

30 September 2017

1 reference

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Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Exosomal-like vesicles are present in human blood plasma

30 September 2017

1 reference

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Small heat shock protein alphaB-crystallin is part of cell cycle-dependent Golgi reorganization

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Nuclear speckle localisation of the small heat shock protein alpha B-crystallin and its inhibition by the R120G cardiomyopathy-linked mutation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Retinal pigment epithelium is protected against apoptosis by alphaB-crystallin.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.

30 September 2017

1 reference

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Responsive polymeric delivery systems.

30 September 2017

1 reference

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Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method

30 September 2017

1 reference

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Phosphorylation-induced change of the oligomerization state of alpha B-crystallin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Characterization of alpha-crystallin-plasma membrane binding

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Sorting and processing of secretory proteins

30 September 2017

1 reference

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Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts.

30 September 2017

1 reference

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The mitochondria-targeted antioxidant SkQ1 restores αB-crystallin expression and protects against AMD-like retinopathy in OXYS rats

30 September 2017

1 reference

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Autophagy and proteotoxicity in cardiomyocytes

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Nuclear staining for the small heat shock protein alphaB-crystallin colocalizes with splicing factor SC35.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Alpha B-crystallin prevents ventricular arrhythmia by attenuating inflammation and oxidative stress in rat with autoimmune myocarditis.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Response of small heat shock proteins in diabetic rat retina.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

α-Crystallin B prevents apoptosis after H2O2 exposure in mouse neonatal cardiomyocytes.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Reduction of experimental diabetic vascular leakage and pericyte apoptosis in mice by delivery of αA-crystallin with a recombinant adenovirus

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

αA-crystallin in the pathogenesis and intervention of experimental murine corneal neovascularization.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Proteomic analysis of microvesicles in human saliva by gel electrophoresis with liquid chromatography-mass spectrometry

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Autophagy, exosomes and drusen formation in age-related macular degeneration

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Sensitization of RPE cells by alphaB-crystallin siRNA to SAHA-induced stage 1 apoptosis through abolishing the association of alphaB-crystallin with HDAC1 in SC35 speckles

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Elevated retina-specific expression of the small heat shock protein, alphaA-crystallin, is associated with photoreceptor protection in experimental uveitis

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

alphaB-crystallin promotes tumor angiogenesis by increasing vascular survival during tube morphogenesis

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Localization of phosphorylated alphaB-crystallin to heart mitochondria during ischemia-reperfusion

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Molecular chaperone alpha-crystallin prevents detrimental effects of neuroinflammation

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Interactive domains for chaperone activity in the small heat shock protein, human alphaB crystallin

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Heat stress-induced localization of small heat shock proteins in mouse myoblasts: intranuclear lamin A/C speckles as target for alphaB-crystallin and Hsp25.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

A comprehensive analysis of the expression of crystallins in mouse retina

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Differential expression of alpha A- and alpha B-crystallin during murine ocular development.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4662643

Crystallin distribution in Bruch's membrane-choroid complex from AMD and age-matched donor eyes

22 September 2018

1 reference

12 December 2020

Synthesis and characterization of a peptide identified as a functional element in alphaA-crystallin

1 reference

12 December 2020

The small heat-shock protein alpha B-crystallin promotes FBX4-dependent ubiquitination

1 reference

12 December 2020

Hyperproliferation and p53 status of lens epithelial cells derived from alphaB-crystallin knockout mice

1 reference

12 December 2020

Human retinal pigment epithelium cell changes and expression of alphaB-crystallin: a biomarker for retinal pigment epithelium cell change in age-related macular degeneration

1 reference

12 December 2020

Interactions between important regulatory proteins and human alphaB crystallin

1 reference

12 December 2020

Alpha A- and alpha B-crystallin in the retina. Association with the post-Golgi compartment of frog retinal photoreceptors

1 reference

12 December 2020

Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers

1 reference

12 December 2020

10.1016/J.BBAGEN.2015.05.016

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26026469%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26026469%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26026469%20AND%20SRC:MED&resulttype=core&format=json