Role of transforming growth factor-beta in cancer progression (Q36677493)

15 August 2017

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title

Role of transforming growth factor-beta in cancer progression (English)

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15 August 2017

Amy J Galliher

1

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15 August 2017

Jason R Neil

series ordinal

2

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15 August 2017

William P Schiemann

series ordinal

3

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15 August 2017

language of work or name

English

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publication date

1 December 2006

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15 August 2017

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15 August 2017

2

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15 August 2017

743-763

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15 August 2017

6

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New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues

15 August 2017

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Role of transforming growth factor beta in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Tumor-stroma interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Transforming growth factor-beta signal transduction in angiogenesis and vascular disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Angiogenesis in health and disease

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.2.6.743

The logic of TGFbeta signaling.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Smad transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Specificity and versatility in tgf-beta signaling through Smads

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Non-Smad TGF-beta signals

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Cell-surface co-receptors: emerging roles in signaling and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Betaglycan presents ligand to the TGF beta signaling receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

TGF-beta receptor function in the endothelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Transforming growth factor beta inhibitory element in the rabbit matrix metalloproteinase-1 (collagenase-1) gene functions as a repressor of constitutive transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

How cells read TGF-beta signals

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Nucleocytoplasmic shuttling of signal transducers.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Ubiquitin-dependent degradation of TGF-beta-activated smad2.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Repression of Smad4 transcriptional activity by SUMO modification

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Role of transforming growth factor Beta in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Role of transforming growth factor-beta in hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

From developmental disorder to heritable cancer: it's all in the BMP/TGF-beta family

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Molecular predictors of survival after adjuvant chemotherapy for colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Transforming growth factor-beta (TGF-beta)-resistant B cells from chronic lymphocytic leukemia patients contain recurrent mutations in the signal sequence of the type I TGF-beta receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Escaping from the TGFbeta anti-proliferative control

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Novel inactivating mutations of transforming growth factor-beta type I receptor gene in head-and-neck cancer metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

TGFBR1*6A may contribute to hereditary colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Somatic acquisition and signaling of TGFBR1*6A in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Loss of Smad3 in acute T-cell lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Smad3 knockout mice exhibit a resistance to skin chemical carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Myc represses transcription through recruitment of DNA methyltransferase corepressor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

A candidate prostate cancer susceptibility gene at chromosome 17p

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Metastasis is driven by sequential elevation of H-ras and Smad2 levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Cyclin-dependent kinases regulate the antiproliferative function of Smads

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Regulation of the human telomerase reverse transcriptase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Transforming growth factor beta suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Epithelial-mesenchymal transitions in tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Epithelial-mesenchymal transitions in development and pathologies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

TGF-beta and epithelial-to-mesenchymal transitions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Smad-binding defective mutant of transforming growth factor beta type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta1 involves MAPK, Smad and AP-1 signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT)

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Critical determinants of metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

The organ microenvironment and cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Stromal fibroblasts in cancer initiation and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Dual role for TGF-beta1 in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Activin/TGF-beta induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

The role of autophagy in cancer development and response to therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

A zinc-finger transcription factor induced by TGF-beta promotes apoptotic cell death in epithelial Mv1Lu cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

The mitochondrial ARTS protein promotes apoptosis through targeting XIAP

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Aberrant rel/nfkb genes and activity in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Transforming growth factor-beta in T-cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Transforming growth factor-beta regulation of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

The activin receptor-like kinase 1 gene: genomic structure and mutations in hereditary hemorrhagic telangiectasia type 2

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Mechanisms of angiogenesis and arteriogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Angiogenesis in cancer and other diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Distinct regulation of gene expression in human endothelial cells by TGF-beta and its receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Extracellular domain of TGFbeta type III receptor inhibits angiogenesis and tumor growth in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

CD105 is important for angiogenesis: evidence and potential applications

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Characterization of murine S-endoglin isoform and its effects on tumor development.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

TGF-beta in cancer and other diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Development of TGF-beta signalling inhibitors for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

The use of cystatin C to inhibit epithelial-mesenchymal transition and morphological transformation stimulated by transforming growth factor-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Fetuin/alpha2-HS glycoprotein is a transforming growth factor-beta type II receptor mimic and cytokine antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

alpha2HS-glycoprotein, an antagonist of transforming growth factor beta in vivo, inhibits intestinal tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Decorin prevents metastatic spreading of breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Adoptive transfer of tumor-reactive transforming growth factor-beta-insensitive CD8+ T cells: eradication of autologous mouse prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Blockade of transforming growth factor-{beta} signaling in tumor-reactive CD8(+) T cells activates the antitumor immune response cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

An oncolytic adenovirus expressing soluble transforming growth factor-beta type II receptor for targeting breast cancer: in vitro evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Replication-selective viruses for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Targeted tumor therapy with the TGF-beta 2 antisense compound AP 12009.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Intracerebral and intrathecal infusion of the TGF-beta 2-specific antisense phosphorothioate oligonucleotide AP 12009 in rabbits and primates: toxicology and safety.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Selective inhibitors of type I receptor kinase block cellular transforming growth factor-beta signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.2.6.743

21 January 2018

Identifiers

DOI

10.2217/14796694.2.6.743

1 reference

15 August 2017

1 reference