PTEN, more than the AKT pathway (Q36753139)

16 August 2017

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title

PTEN, more than the AKT pathway (English)

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16 August 2017

Juan F M Leal

3

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Oliver Renner

object named as

Oliver Renner

series ordinal

2

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Carmen Blanco-Aparicio

object named as

Carmen Blanco-Aparicio

series ordinal

1

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Amancio Carnero

object named as

Amancio Carnero

series ordinal

4

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language of work or name

English

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publication date

6 March 2007

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16 August 2017

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16 August 2017

28

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16 August 2017

7

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16 August 2017

1379-1386

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

16 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

PTEN, a unique tumor suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

PI 3-kinase, Akt and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Cellular survival: a play in three Akts

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

The akt kinase: molecular determinants of oncogenicity

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Akt-dependent transformation: there is more to growth than just surviving

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Oncogenic kinase signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Membrane localization of all class I PI 3-kinase isoforms suppresses c-Myc-induced apoptosis in Rat1 fibroblasts via Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Oncogenic PI3K and its role in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Akt signaling and cancer: surviving but not moving on.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Ten years of protein kinase B signalling: a hard Akt to follow

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Colorectal cancer: mutations in a signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Clinical and pathological features of breast disease in Cowden's syndrome: an underrecognized syndrome with an increased risk of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

High frequency of mutations of the PIK3CA gene in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

The PIK3CA gene is mutated with high frequency in human breast cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

AKT activation predicts outcome in breast cancer patients treated with tamoxifen

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Mutation of the PIK3CA gene in anaplastic thyroid cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Pten is essential for embryonic development and tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Genetic background controls tumor development in PTEN-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Knockout mouse models and mammary tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

A new mouse model of pancreatic cancer: PTEN gets its Akt together

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Conditional Akt activation promotes androgen-independent progression of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Mammary ductal and alveolar development: lesson learned from genetically manipulated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

PDK1, the master regulator of AGC kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Mechanism of activation and function of protein kinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Human tumor mutants in the p110alpha subunit of PI3K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Cancer-specific mutations in PIK3CA are oncogenic in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

PTEN regulates Mdm2 expression through the P1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Mechanistic insights into maintenance of high p53 acetylation by PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

PTEN enters the nuclear age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Nuclear Ptdlns(3,4,5)P3 signaling: an ongoing story

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Class reunion: PTEN joins the nuclear crew.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Essential role for nuclear PTEN in maintaining chromosomal integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

PTEN: a novel anti-oncogenic function independent of phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

RETRACTED: Regulation of p53: intricate loops and delicate balances

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM052

21 January 2018

Identifiers

DOI

10.1093/CARCIN/BGM052

1 reference

16 August 2017

1 reference

PubMed ID

17341655