Lithium: a novel treatment for Alzheimer's disease? (Q36905840)

17 August 2017

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title

Lithium: a novel treatment for Alzheimer's disease? (English)

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17 August 2017

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Jin Zhong

1

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PubMed ID

17688381

17 August 2017

Wei-Hua Lee

series ordinal

2

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PubMed ID

17688381

17 August 2017

language of work or name

English

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publication date

1 July 2007

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Expert Opinion on Drug Safety

17 August 2017

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17 August 2017

6

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17 August 2017

4

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17 August 2017

375-383

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Suicide risk in bipolar disorder during treatment with lithium and divalproex

17 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Lithium induces apoptosis in immature cerebellar granule cells but promotes survival of mature neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Lithium protects ethanol-induced neuronal apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Implication of cyclin-dependent kinase 5 in the neuroprotective properties of lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N-methyl-D-aspartate receptor-mediated excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Protracted lithium treatment protects against the ER stress elicited by thapsigargin in rat PC12 cells: roles of intracellular calcium, GRP78 and Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Evaluation of neuroprotection by lithium and valproic acid against ouabain-induced cell damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Lithium: potential therapeutics against acute brain injuries and chronic neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Prevention of MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) dopaminergic neurotoxicity in mice by chronic lithium: involvements of Bcl-2 and Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Short-term lithium treatment promotes neuronal survival and proliferation in rat striatum infused with quinolinic acid, an excitotoxic model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

The mechanism of lithium action: state of the art, ten years later

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Reduced Brain Inositol in Lithium-treated Rats

21 January 2018

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https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Increased brain myo-inositol 1-phosphate in lithium-treated rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

The role of CDK5/P25 formation/inhibition in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Role of neurotrophic factors in depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Trk receptors: mediators of neurotrophin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

GSK-3: tricks of the trade for a multi-tasking kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Glycogen synthase kinase 3: a drug target for CNS therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Lithium and valproic acid: parallels and contrasts in diverse signaling contexts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

A molecular mechanism for the effect of lithium on development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Neurogenesis in the adult human hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Learning enhances adult neurogenesis in the hippocampal formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Experience-dependent regulation of adult hippocampal neurogenesis: effects of long-term stimulation and stimulus withdrawal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Genetic influence on neurogenesis in the dentate gyrus of adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Genetic influence on neurogenesis in the dentate gyrus of two strains of adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Brain-derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

The role of tau phosphorylation in the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Neurodegenerative tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Glycogen synthase kinase 3: an emerging therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Multiple roles for glycogen synthase kinase-3 as a drug target in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Serum Level Monitoring and Clinical Pharmacokinetics of Lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Brain lithium concentrations measured with lithium-7 magnetic resonance spectroscopy in patients with affective disorders: relationship to erythrocyte and serum concentrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Comparison of metoprolol and propranolol in the treatment of lithium tremor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Lithium-induced nephropathy: Rate of progression and prognostic factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Clinical relevance of drug interactions with lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Lithium treatment in older patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Long-lasting neurological sequelae after lithium intoxication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

The syndrome of irreversible lithium-effectuated neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Neurological side effects of lithium: organic brain syndrome, seizures, extrapyramidal side effects, and EEG changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Lithium and dementia: a preliminary study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Does lithium therapy protect against the onset of dementia?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Treatment of Alzheimer's disease: current status and new perspectives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Memantine in moderate-to-severe Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.6.4.375

21 January 2018

Identifiers

DOI

10.1517/14740338.6.4.375

1 reference

17 August 2017

1 reference

PubMed ID

17688381