Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator. (Q37102798)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23961261%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

title

Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator (English)

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7 March 2020

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1

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7 March 2020

author name string

Fabian V Filipp

series ordinal

1

1 reference

18 August 2017

language of work or name

English

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publication date

24 July 2013

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Journal of Carcinogenesis

7 March 2020

published in

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7 March 2020

volume

12

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7 March 2020

page(s)

14

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Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals

7 March 2020

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ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

14 September 2017

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EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis

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SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions

14 September 2017

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Serine is a natural ligand and allosteric activator of pyruvate kinase M2

14 September 2017

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

14 September 2017

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

14 September 2017

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PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis

14 September 2017

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Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma.

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Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

14 September 2017

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Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells

14 September 2017

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Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

14 September 2017

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Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

14 September 2017

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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

14 September 2017

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Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons

14 September 2017

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Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect

14 September 2017

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No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

14 September 2017

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Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase

14 September 2017

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Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

14 September 2017

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Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

14 September 2017

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Alternative isoform regulation in human tissue transcriptomes

14 September 2017

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The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways

14 September 2017

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

14 September 2017

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

14 September 2017

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Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism

14 September 2017

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14 September 2017

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Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death

14 September 2017

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Systems biology: a brief overview

14 September 2017

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

14 September 2017

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29 September 2017

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Mass spectrometric analysis reveals O-methylation of pyruvate kinase from pancreatic cancer cells

29 September 2017

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Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply

27 June 2018

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Crystallization, characterization and metabolic regulation of two types of pyruvate kinase isolated from rat tissues

27 June 2018

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Regulation of thyroid hormone binding to its cytosolic binding protein by L-alpha-alanine

27 June 2018

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The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2.

27 June 2018

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3 September 2018

Identifiers

DOI

10.4103/1477-3163.115423

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23961261%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23961261%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

PubMed publication ID

23961261

1 reference