Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells (Q37123913)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23979164%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells (English)

1 reference

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8 March 2020

1 reference

acute myeloid leukemia

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author

Masahiro Nakagawa

7

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8 March 2020

H. Leighton Grimes

12

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8 March 2020

author name string

Susumu Goyama

1

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8 March 2020

Janet Schibler

2

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8 March 2020

Lea Cunningham

3

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8 March 2020

Yue Zhang

4

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8 March 2020

Yalan Rao

5

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8 March 2020

Nahoko Nishimoto

6

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8 March 2020

Andre Olsson

8

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8 March 2020

Mark Wunderlich

9

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8 March 2020

Kevin A Link

10

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8 March 2020

Benjamin Mizukawa

11

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8 March 2020

Mineo Kurokawa

13

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8 March 2020

P Paul Liu

14

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8 March 2020

Gang Huang

15

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8 March 2020

James C Mulloy

16

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8 March 2020

language of work or name

English

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publication date

27 August 2013

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Journal of Clinical Investigation

8 March 2020

published in

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8 March 2020

volume

123

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8 March 2020

issue

9

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8 March 2020

page(s)

3876-3888

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RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction

8 March 2020

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The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.

14 September 2017

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Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

14 September 2017

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AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

14 September 2017

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

14 September 2017

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MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

14 September 2017

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p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia.

14 September 2017

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A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

14 September 2017

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Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects

14 September 2017

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AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3

14 September 2017

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Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

14 September 2017

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

14 September 2017

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Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1

14 September 2017

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Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis

14 September 2017

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Cbfb/Runx1 repression-independent blockage of differentiation and accumulation of Csf2rb-expressing cells by Cbfb-MYH11.

14 September 2017

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Core binding factor at the crossroads: determining the fate of the HSC.

14 September 2017

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Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling

14 September 2017

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Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia

14 September 2017

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PML targeting eradicates quiescent leukaemia-initiating cells

14 September 2017

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p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death

14 September 2017

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AML1/Runx1 as a versatile regulator of hematopoiesis: regulation of its function and a role in adult hematopoiesis

14 September 2017

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Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

14 September 2017

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Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability

14 September 2017

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Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.

14 September 2017

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AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

14 September 2017

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14 September 2017

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Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

14 September 2017

1 reference

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The AML1/ETO fusion protein activates transcription of BCL-2

14 September 2017

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Characterization of a new myeloid leukemia cell line with normal cytogenetics (CG-SH).

14 September 2017

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The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3754260

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3754260

Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer

29 September 2017

1 reference

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Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3754260

Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation.

3 September 2018

1 reference

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Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)

3 September 2018

1 reference

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Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through down-regulation of p19ARF.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3754260

AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations.

3 September 2018

1 reference

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Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction

3 September 2018

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Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development.

3 September 2018

1 reference

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High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia

3 September 2018

1 reference

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Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element

3 September 2018

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Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent Alterations in TET2, CBL, RAS, and RUNX1

3 September 2018

1 reference

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Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis

4 December 2018

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12 December 2020

Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors

1 reference

12 December 2020

Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult

1 reference

12 December 2020

RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis

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12 December 2020

Identifiers

DOI

10.1172/JCI68557

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23979164%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23979164%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

PubMed publication ID

23979164

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23979164%20AND%20SRC:MED&resulttype=core&format=json