An insight into molecular mechanisms of human T helper cell differentiation (Q37165356)

18 August 2017

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title

An insight into molecular mechanisms of human T helper cell differentiation (English)

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18 August 2017

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5

Riitta Lahesmaa

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18 August 2017

Kirsi J Rautajoki

1

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18 August 2017

Minna K Kylaniemi

series ordinal

2

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18 August 2017

Sunil K Raghav

series ordinal

3

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18 August 2017

Kanury Rao

series ordinal

4

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18 August 2017

language of work or name

English

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publication date

1 January 2008

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18 August 2017

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18 August 2017

40

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18 August 2017

5

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18 August 2017

322-335

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Molecular mechanisms regulating Th1 immune responses

18 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Signaling pathways in Th2 development

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890802068582

Differentiation and function of Th17 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890802068582

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890802068582

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Phenotypic and functional features of human Th17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890802068582

Sustained IL-12 signaling is required for Th1 development

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890802068582

New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890802068582

Cloning of a new cytokine that induces IFN-gamma production by T cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890802068582

IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12Rbeta2 expression during human Th1 cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890802068582

Distinct regulation of interleukin-17 in human T helper lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890802068582

Development, cytokine profile and function of human interleukin 17-producing helper T cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890802068582

The IL-4 receptor: signaling mechanisms and biologic functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890802068582

The initial response of CD4+ IL-4-producing cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Interleukin 2 plays a central role in Th2 differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

The two faces of IL-6 on Th1/Th2 differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

IL-17 family cytokines and the expanding diversity of effector T cell lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Intracellular JNK, p38 MAPK and NF-kappaB regulate IL-25 induced release of cytokines and chemokines from costimulated T helper lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Early target genes of IL-12 and STAT4 signaling in th cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Kinetics and STAT4- or STAT6-mediated regulation of genes involved in lymphocyte polarization to Th1 and Th2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

A novel transcription factor, T-bet, directs Th1 lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Evolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Genetic Reprogramming of Primary Human T Cells Reveals Functional Plasticity in Th Cell Differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

T-bet polymorphisms are associated with asthma and airway hyperresponsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Association analysis of novel TBX21 variants with asthma phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Association study of 15 novel single-nucleotide polymorphisms of the T-bet locus among Finnish asthma families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Signaling mechanisms, interaction partners, and target genes of STAT6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Essential role of Stat6 in IL-4 signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Enrichment of nucleofected primary human CD4+ T cells: a novel and efficient method for studying gene function and role in human primary T helper cell differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Identification of novel IL-4/Stat6-regulated genes in T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Notch directly regulates Gata3 expression during T helper 2 cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

GATA-3 in human T cell helper type 2 development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

GATA-3 suppresses IFN-gamma promoter activity independently of binding to cis-regulatory elements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Friend of GATA is expressed in naive Th cells and functions as a repressor of GATA-3-mediated Th2 cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: evidence for differential signal transducer and activator of transcription 6 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

T helper type 2 cytokine receptors and associated transcription factors GATA-3, c-MAF, and signal transducer and activator of transcription factor-6 in induced sputum of atopic asthmatic patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Regulation of GATA-3, c-maf and T-bet mRNA expression in bronchoalveolar lavage cells and bronchial biopsies after segmental allergen challenge.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Tumor necrosis factor receptor-associated factor (TRAF)2 represses the T helper cell type 2 response through interaction with NFAT-interacting protein (NIP45).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

ICOS co-stimulatory receptor is essential for T-cell activation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

B7h is required for T cell activation, differentiation, and effector function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Transcriptional regulation of th2 differentiation by inducible costimulator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Regulation of naive T cell differentiation by varying the potency of TCR signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

NFAT proteins: key regulators of T-cell development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Regulation of interferon-gamma gene expression by nuclear factor of activated T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Identification of Highly Expressed Genes in Peripheral Blood T Cells from Patients with Atopic Dermatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Itk and Th2 responses: action but no reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

The TIM gene family regulates autoimmune and allergic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Caspases at the crossroads of immune-cell life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Effector CD4+ T cells generate intermediate caspase activity and cleavage of caspase-8 substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

A role for caspases in controlling IL-4 expression in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Responding naive T cells differ in their sensitivity to Fas engagement: early death of many T cells is compensated by costimulation of surviving T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Cellular FLIP (long isoform) overexpression in T cells drives Th2 effector responses and promotes immunoregulation in experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Cellular FLICE-inhibitory protein is required for T cell survival and cycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Inhibition of death receptor signals by cellular FLIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

An epigenetic view of helper T cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

DNA methylation changes at human Th2 cytokine genes coincide with DNase I hypersensitive site formation during CD4(+) T cell differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Effect of promoter methylation on the regulation of IFN-gamma gene during in vitro differentiation of human peripheral blood T cells into a Th2 population

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Proteome profiling of interleukin-12 treated human T helper cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Transcript imaging of the development of human T helper cells using oligonucleotide arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Identification of genes involved in the initiation of human Th1 or Th2 cell commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Characterization of microsomal fraction proteome in human lymphoblasts reveals the down-regulation of galectin-1 by interleukin-12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Systematic construction of gene coexpression networks with applications to human T helper cell differentiation process

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Capturing cell-fate decisions from the molecular signatures of a receptor-dependent signaling response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Interleukin-4 Inhibits Caspase-3 by Regulating Several Proteins in the Fas Pathway during Initial Stages of Human T Helper 2 Cell Differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

Proteomic and transcriptomic characterization of interferon-?-induced human primary T helper cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890802068582

10.1080/07853890802068582

21 January 2018

Identifiers

DOI

1 reference

18 August 2017

1 reference