Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch (Q37241773)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851691%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch (English)

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5 March 2020

6

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Juan Carlos Zuniga-Pflucker

5 March 2020

8

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5 March 2020

author name string

Dzana D Dervovic

1

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5 March 2020

Haydn C-Y Liang

2

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5 March 2020

Jennifer L Cannons

3

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5 March 2020

Alisha R Elford

4

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5 March 2020

Mahmood Mohtashami

5

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5 March 2020

Pamela L Schwartzberg

7

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5 March 2020

language of work or name

English

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publication date

12 July 2013

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5 March 2020

published in

Journal of Immunology

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5 March 2020

volume

191

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5 March 2020

issue

4

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5 March 2020

page(s)

1704-1715

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Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus

5 March 2020

cites work

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Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells.

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HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.

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Clonal deletion and the fate of autoreactive thymocytes that survive negative selection

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6 September 2017

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CD8 T cells producing IL-17 and IFN-gamma initiate the innate immune response required for responses to antigen skin challenge

6 September 2017

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The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development

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SLAM receptors and SAP influence lymphocyte interactions, development and function

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MHC class II-dependent T-T interactions create a diverse, functional and immunoregulatory reaction circle

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Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice

6 September 2017

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Requirements for selection of conventional and innate T lymphocyte lineages

6 September 2017

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Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes

6 September 2017

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Presenilins regulate alphabeta T cell development by modulating TCR signaling

6 September 2017

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Development and selection of Valpha l4i NKT cells.

6 September 2017

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Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development

6 September 2017

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Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

6 September 2017

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The immunoregulatory effects of Qa-1.

6 September 2017

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Central tolerance: good but imperfect

6 September 2017

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TCR and Notch signaling in CD4 and CD8 T-cell development

6 September 2017

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Commitment issues: linking positive selection signals and lineage diversification in the thymus

6 September 2017

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6 September 2017

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Molecular genetics of T cell development

6 September 2017

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Receptor signals and nuclear events in CD4 and CD8 T cell lineage commitment

6 September 2017

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Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product

6 September 2017

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6 September 2017

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6 September 2017

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T-cell development made simple

6 September 2017

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Negative selection--clearing out the bad apples from the T-cell repertoire

6 September 2017

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The Ras/MAPK cascade and the control of positive selection

6 September 2017

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Positive and negative selection of T cells

6 September 2017

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Lymphostromal interactions in thymic development and function

6 September 2017

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Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength

6 September 2017

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Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes

6 September 2017

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Positive selection of thymocytes: the long and winding road.

6 September 2017

1 reference

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Correlating notch signaling with thymocyte maturation

6 September 2017

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CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

6 September 2017

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Major histocompatibility complex (MHC) class I KbDb -/- deficient mice possess functional CD8+ T cells and natural killer cells

6 September 2017

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Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection

6 September 2017

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Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture

6 September 2017

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Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.

6 September 2017

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6 September 2017

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

6 September 2017

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T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice

6 September 2017

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The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems

6 September 2017

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Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes.

6 September 2017

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Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells

14 September 2017

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Signaling lymphocyte activation molecule-associated protein is a negative regulator of the CD8 T cell response in mice

14 September 2017

1 reference

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Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism

14 September 2017

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Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation

14 September 2017

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Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro

14 September 2017

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Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

14 September 2017

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Positive selection of T cells

14 September 2017

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SAP Protein-Dependent Natural Killer T-like Cells Regulate the Development of CD8+ T Cells with Innate Lymphocyte Characteristics

14 September 2017

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Notch-induced T cell development requires phosphoinositide-dependent kinase 1.

26 June 2018

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Positive selection of MHC class Ib-restricted CD8(+) T cells on hematopoietic cells

26 June 2018

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An activated form of Notch influences the choice between CD4 and CD8 T cell lineages

26 June 2018

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Mature T cell reactivity altered by peptide agonist that induces positive selection

26 June 2018

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Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk.

26 June 2018

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The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.

3 September 2018

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Tec kinases in T cell development: a clue behind the mask?

3 September 2018

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Thymocyte-thymocyte interaction for efficient positive selection and maturation of CD4 T cells.

3 September 2018

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Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling

3 September 2018

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Analysis of regulatory CD8 T cells in Qa-1-deficient mice

3 September 2018

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Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development.

3 September 2018

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The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate.

3 September 2018

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Evidence for a differential avidity model of T cell selection in the thymus

3 September 2018

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Breaking immunologic ignorance to an antigenic peptide of simian virus 40 large T antigen.

3 September 2018

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Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation

3 September 2018

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12 December 2020

T cell progenitors in the murine fetal liver: differences from those in the adult bone marrow

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12 December 2020

Thymocytes positively select thymocytes in human system

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12 December 2020

Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes

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12 December 2020

A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development

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12 December 2020

T cell tolerance by clonal elimination in the thymus

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12 December 2020

Positive and negative thymocyte selection induced by different concentrations of a single peptide

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12 December 2020

From vanilla to 28 flavors: multiple varieties of T regulatory cells

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12 December 2020

Foxp3 and Aire in thymus-generated Treg cells: a link in self-tolerance

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12 December 2020

T-cell development: thymus-settling progenitors: settled?

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12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1300417

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851691%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851691%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PubMed publication ID

23851691

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851691%20AND%20SRC:MED&resulttype=core&format=json