Therapeutic potential of RNA interference in drug-resistant cancers (Q37414354)

20 August 2017

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title

Therapeutic potential of RNA interference in drug-resistant cancers (English)

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20 August 2017

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Hermann Lage

1

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20 August 2017

language of work or name

English

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publication date

1 March 2009

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20 August 2017

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20 August 2017

volume

5

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20 August 2017

issue

2

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20 August 2017

page(s)

169-185

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

20 August 2017

cites work

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

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Prospects of RNA interference therapy for cancer

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

siRNAs: applications in functional genomics and potential as therapeutics

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Applications of RNA interference in mammalian systems.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Potential applications of RNA interference technology in the treatment of cancer

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Illuminating the silence: understanding the structure and function of small RNAs

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

ATP requirements and small interfering RNA structure in the RNA interference pathway

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Functional genomics using high-throughput RNA interference

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Validating survivin as a cancer therapeutic target

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Knockdown of survivin expression by small interfering RNA reduces the clonogenic survival of human sarcoma cell lines independently of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Survivin stable knockdown by siRNA inhibits tumor cell growth and angiogenesis in breast and cervical cancers.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Survivin modulates microtubule dynamics and nucleation throughout the cell cycle

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

An overview of cancer multidrug resistance: a still unsolved problem

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Targeting multidrug resistance in cancer

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: a phase III trial (E2995)

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95): a trial of the Eastern Cooperative Oncology Gr

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Phase I study of docetaxel in combination with the P-glycoprotein inhibitor, zosuquidar, in resistant malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

A Phase I trial of a potent P-glycoprotein inhibitor, zosuquidar trihydrochloride (LY335979), administered intravenously in combination with doxorubicin in patients with advanced malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

MDR1/P-glycoprotein (ABCB1) as target for RNA interference-mediated reversal of multidrug resistance

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

The cytotoxic effect of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells is modulated by the expression level of MRP1 but not MDR1.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Reversal of different drug-resistant phenotypes by an autocatalytic multitarget multiribozyme directed against the transcripts of the ABC transporters MDR1/P-gp, MRP2, and BCRP.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Complete reversal of ABCG2-depending atypical multidrug resistance by RNA interference in human carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

RNA interference-triggered reversal of ABCC2-dependent cisplatin resistance in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

The gene-silencing efficiency of siRNA is strongly dependent on the local structure of mRNA at the targeted region

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Effects on RNAi of the tight structure, sequence and position of the targeted region.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

siRNA efficiency: structure or sequence-that is the question

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Strategies for inhibition of MDR1 gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

A case study in misidentification of cancer cell lines: MCF-7/AdrR cells (re-designated NCI/ADR-RES) are derived from OVCAR-8 human ovarian carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Stable and complete overcoming of MDR1/P-glycoprotein-mediated multidrug resistance in human gastric carcinoma cells by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Delivery of MDR1 small interfering RNA by self-complementary recombinant adeno-associated virus vector

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Persistent use of "false" cell lines

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

In vivo RNA interference-mediated ablation of MDR1 P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Sequence-specific suppression of mdr1a/1b expression in mice via RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

In vivo reversal of P-glycoprotein-mediated multidrug resistance by efficient delivery of stealth RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Complete in vivo reversal of the multidrug resistance phenotype by jet-injection of anti-MDR1 short hairpin RNA-encoding plasmid DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Novel jet-injection technology for nonviral intratumoral gene transfer in patients with melanoma and breast cancer

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Low-volume jet injection for efficient nonviral in vivo gene transfer

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Nonviral jet-injection gene transfer for efficient in vivo cytosine deaminase suicide gene therapy of colon carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Transcriptional regulation of ABC drug transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Regulation of MDR1 gene expression in multidrug-resistant cancer cells is independent from YB-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

RPN2 gene confers docetaxel resistance in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Induction and suppression of RNA silencing: insights from viral infections

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Development of resistance to RNAi in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Activation of the interferon system by short-interfering RNAs

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

PKR, apoptosis and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Gene structure and function of the 2'-5'-oligoadenylate synthetase family.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Expression of platelet glycoprotein (GP) V in heterologous cells and evidence for its association with GP Ib alpha in forming a GP Ib-IX-V complex on the cell surface.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

The role of 2'-5' oligoadenylate-activated ribonuclease L in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

In situ fluorescence analysis demonstrates active siRNA exclusion from the nucleus by Exportin 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Specificity of short interfering RNA determined through gene expression signatures

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Off-target effects by siRNA can induce toxic phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Strategies for in vivo siRNA delivery in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

RNAi-mediated gene silencing in non-human primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Transvascular delivery of small interfering RNA to the central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Interfering with disease: a progress report on siRNA-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Specific inhibition of bcr-abl gene expression by small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Stable suppression of tumorigenicity by virus-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

The small GTPase R-Ras regulates organization of actin and drives membrane protrusions through the activity of PLCepsilon

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumorgrowth in a model of human ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Tumor regression in mice by delivery of Bcl-2 small interfering RNA with pegylated cationic liposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Fibroblast growth factor receptor 3 inhibition by short hairpin RNAs leads to apoptosis in multiple myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Effect of blocking VEGF, hTERT and Bcl-xl by multiple shRNA expression vectors on the human laryngeal squamous carcinoma xenograft in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Stable gene silencing of cyclin B1 in tumor cells increases susceptibility to taxol and leads to growth arrest in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Genotoxic stress induces expression of E2F4, leading to its association with p130 in prostate carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Induction of cell death in human papillomavirus 18-positive cervical cancer cells by E6 siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

New highly potent and specific E6 and E7 siRNAs for treatment of HPV16 positive cervical cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

shRNA-targeted hTERT suppress cell proliferation of bladder cancer by inhibiting telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Downregulating the expression of heparanase inhibits the invasion, angiogenesis and metastasis of human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Short hairpin RNA-mediated inhibition of matrix metalloproteinase-1 in MDA-231 cells: effects on matrix destruction and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Adenovirus-mediated small interfering RNA against matrix metalloproteinase-2 suppresses tumor growth and lung metastasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Intraperitoneal injection of a hairpin RNA-expressing plasmid targeting urokinase-type plasminogen activator (uPA) receptor and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Vector-based RNAi, a novel tool for isoform-specific knock-down of VEGF and anti-angiogenesis gene therapy of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

The reversion effect of the RNAi-silencing mdr1 gene on multidrug resistance of the leukemia cell HT9.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

The reduction of P-glycoprotein expression by small interfering RNAs is improved in exponentially growing cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Modulation of MDR1 gene expression in multidrug resistant MCF7 cells by low concentrations of small interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Reversal of MDR1 gene-dependent multidrug resistance using low concentration of endonuclease-prepared small interference RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Modulation of the efficiency of a siRNA directed against MDR1 expression in MCF7-R cells when combined with a second siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Silencing of MDR 1 gene in cancer cells by siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Reversal of P-glycoprotein-mediated multidrug resistance with small interference RNA (siRNA) in leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Stable suppression of MDR1 gene expression and function by RNAi in Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Construction of a functional transporter analysis system using MDR1 knockdown Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Combination gene therapy using multidrug resistance (MDR1) gene shRNA and herpes simplex virus-thymidine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Reversion of multidrug resistance in human glioma by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Reversing multidrug resistance by RNA interference through the suppression of MDR1 gene in human hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Inhibition of multi-drug resistance of ovarian carcinoma by small interfering RNA targeting to MRP2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

Reversal of BCRP-mediated multidrug resistance by stable expression of small interfering RNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.169

21 January 2018

Identifiers

DOI

10.2217/14796694.5.2.169

1 reference

20 August 2017

1 reference