Assembling the building blocks: structure and function of inhibitor of apoptosis proteins (Q37448134)

20 August 2017

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title

Assembling the building blocks: structure and function of inhibitor of apoptosis proteins (English)

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20 August 2017

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3

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20 August 2017

P D Mace

1

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PubMed ID

19373243

20 August 2017

S Shirley

series ordinal

2

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20 August 2017

1 January 2010

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Cell Death & Differentiation

20 August 2017

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20 August 2017

17

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20 August 2017

1

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20 August 2017

46-53

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https://scigraph.springernature.com/pub.10.1038/cdd.2009.45

20 August 2017

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Molecular mechanisms of caspase regulation during apoptosis

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IAPs, RINGs and ubiquitylation

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Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

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7 January 2021

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

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7 January 2021

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

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7 January 2021

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)

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7 January 2021

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

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7 January 2021

Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat

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NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

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7 January 2021

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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7 January 2021

Structural basis of IAP recognition by Smac/DIABLO

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7 January 2021

Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides

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7 January 2021

Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim

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XIAP Induces NF-κB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization

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Mechanism of XIAP-mediated inhibition of caspase-9

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Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles

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Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance

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An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

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Solution Structure of the Hdm2 C2H2C4 RING, a Domain Critical for Ubiquitination of p53

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Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

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7 January 2021

Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment

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7 January 2021

The death domain superfamily in intracellular signaling of apoptosis and inflammation

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7 January 2021

Mechanisms of caspase activation and inhibition during apoptosis

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7 January 2021

Structural basis of caspase-7 inhibition by XIAP

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7 January 2021

Structural basis for the inhibition of caspase-3 by XIAP

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7 January 2021

NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP

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7 January 2021

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

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7 January 2021

The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases

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7 January 2021

Inactivation of effector caspases through nondegradative polyubiquitylation

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https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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7 January 2021

Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

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https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ

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https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis

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https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

The inhibitor of apoptosis proteins as therapeutic targets in cancer

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https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

New apoptosis drugs face critical test

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https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer

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https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases

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https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

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https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

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https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

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https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

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https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling

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https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and c-IAP2) in vitro

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

Protein-protein interactions regulate Ubl conjugation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

IAP-IAP complexes required for apoptosis resistance of C. trachomatis-infected cells

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

A novel role for XIAP in copper homeostasis through regulation of MURR1

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.45

7 January 2021

Identifiers

DOI

10.1038/CDD.2009.45

1 reference

PubMed ID

19373243

Dimensions Publication ID

20 August 2017

0 references

1 reference

PubMed ID

19373243