Metal ion physiopathology in neurodegenerative disorders (Q37641152)

21 August 2017

1 reference

title

Metal ion physiopathology in neurodegenerative disorders (English)

1 reference

21 August 2017

1 reference

Luigi Messori

2

0 references

author name string

Silvia Bolognin

series ordinal

1

1 reference

PubMed ID

19946766

21 August 2017

Paolo Zatta

series ordinal

3

1 reference

21 August 2017

28 November 2009

1 reference

21 August 2017

NeuroMolecular Medicine

1 reference

21 August 2017

11

1 reference

21 August 2017

223-238

1 reference

21 August 2017

4

1 reference

https://scigraph.springernature.com/pub.10.1007/s12017-009-8102-1

21 August 2017

0 references

cites work

Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1007%2FS12017-009-8102-1

Role of metal ions in the abeta oligomerization in Alzheimer's disease and in other neurological disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-009-8102-1

21 January 2018

Cellular iron transport

1 reference

https://api.crossref.org/works/10.1007%2FS12017-009-8102-1

Nanoparticle and other metal chelation therapeutics in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-009-8102-1

Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-009-8102-1

Excess of serum copper not related to ceruloplasmin in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-009-8102-1

Update on human prion disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-009-8102-1

Iron toxicity in diseases of aging: Alzheimer's disease, Parkinson's disease and atherosclerosis

21 January 2018

1 reference

12 December 2020

Aluminium in Alzheimer's disease: are we still at a crossroad?

1 reference

12 December 2020

Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element

1 reference

12 December 2020

Consequences of manganese replacement of copper for prion protein function and proteinase resistance

1 reference

12 December 2020

Demonstration of aluminum in amyloid fibers in the cores of senile plaques in the brains of patients with Alzheimer's disease

1 reference

12 December 2020

Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial

1 reference

12 December 2020

Zn(2+): a novel ionic mediator of neural injury in brain disease.

1 reference

12 December 2020

Quantification of trace elements in normal human brain by inductively coupled plasma atomic emission spectrometry.

1 reference

12 December 2020

Mechanisms of tau-induced neurodegeneration

1 reference

12 December 2020

Aggregation/fibrillogenesis of recombinant human prion protein and Gerstmann-Sträussler-Scheinker disease peptides in the presence of metal ions

1 reference

12 December 2020

Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase

1 reference

12 December 2020

Protein misfolding and neurodegeneration

1 reference

12 December 2020

General aspects of neurodegeneration.

1 reference

12 December 2020

Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide

1 reference

12 December 2020

Increased serum ferritin levels in amyotrophic lateral sclerosis (ALS) patients

1 reference

12 December 2020

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

1 reference

12 December 2020

Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis

1 reference

12 December 2020

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

1 reference

12 December 2020

Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis.

1 reference

12 December 2020

Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.

1 reference

12 December 2020

Aluminum-triggered structural modifications and aggregation of beta-amyloids

1 reference

12 December 2020

Serum zinc in the progression of Alzheimer's disease.

1 reference

12 December 2020

Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading

1 reference

12 December 2020

The effects of enhanced zinc on spatial memory and plaque formation in transgenic mice.

1 reference

12 December 2020

Metal concentrations in plasma and cerebrospinal fluid in patients with Alzheimer's disease.

1 reference

12 December 2020

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

1 reference

12 December 2020

Prion protein fate governed by metal binding

1 reference

12 December 2020

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

1 reference

12 December 2020

Synaptic structural dynamics and aging

1 reference

12 December 2020

Metallothioneins are highly expressed in astrocytes and microcapillaries in Alzheimer's disease.

1 reference

12 December 2020

A potential pathogenetic role of iron in Alzheimer's disease.

1 reference

12 December 2020

Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite

1 reference

12 December 2020

Copper perturbation in 2 monozygotic twins discordant for degree of cognitive impairment.

1 reference

12 December 2020

Copper chelation delays the onset of prion disease

1 reference

12 December 2020

Regional distribution of manganese, iron, copper, and zinc in the rat brain during development

1 reference

12 December 2020

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

1 reference

12 December 2020

An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

1 reference

12 December 2020

Accumulation of copper and other metal ions, and metallothionein I/II expression in the bovine brain as a function of aging

1 reference

12 December 2020

Metal-dependent alpha-helix formation promoted by the glycine-rich octapeptide region of prion protein

1 reference

12 December 2020

Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities

1 reference

12 December 2020

A reassessment of copper(II) binding in the full-length prion protein

1 reference

12 December 2020

Release of glutamate and GABA in the hippocampus under zinc deficiency

1 reference

12 December 2020

Metal-dependent generation of reactive oxygen species from amyloid proteins implicated in neurodegenerative disease.

1 reference

12 December 2020

Excessive oral zinc supplementation

1 reference

12 December 2020

Metals in Alzheimer's and Parkinson's diseases

1 reference

12 December 2020

Free copper and resting temporal EEG rhythms correlate across healthy, mild cognitive impairment, and Alzheimer's disease subjects.

1 reference

12 December 2020

The role of iron in neurodegeneration: prospects for pharmacotherapy of Parkinson's disease

1 reference

12 December 2020

Brain, aging and neurodegeneration: role of zinc ion availability

1 reference

12 December 2020

Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease

1 reference

12 December 2020

Aluminum, calcium, and iron in the spinal cord of patients with sporadic amyotrophic lateral sclerosis using laser microprobe mass spectroscopy: a preliminary study

1 reference

12 December 2020

The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice

1 reference

12 December 2020

Serum chemical elements and oxidative status in Alzheimer's disease, Parkinson disease and multiple sclerosis

1 reference

12 December 2020

The neurobiology of zinc in health and disease

1 reference

12 December 2020

Potential pathogenic role of beta-amyloid(1-42)-aluminum complex in Alzheimer's disease

1 reference

12 December 2020

Ironing out Parkinson's disease: is therapeutic treatment with iron chelators a real possibility?

1 reference

12 December 2020

In vivo imaging of functional disruption, recovery and alteration in rat olfactory circuitry after lesion.

1 reference

12 December 2020

Aluminum-induced structural alterations of the precursor of the non-A beta component of Alzheimer's disease amyloid

1 reference

12 December 2020

Copper, iron and zinc in Alzheimer's disease senile plaques.

1 reference

12 December 2020

Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

1 reference

12 December 2020

New insights into cellular prion protein (PrPc) functions: the "ying and yang" of a relevant protein.

1 reference

12 December 2020

The cellular machinery of Ferroplasma acidiphilum is iron-protein-dominated.

1 reference

12 December 2020

A vicious circle: role of oxidative stress, intraneuronal Abeta and Cu in Alzheimer's disease

1 reference

12 December 2020

Excess of nonceruloplasmin serum copper in AD correlates with MMSE, CSF [beta]-amyloid, and h-tau.

1 reference

12 December 2020

The metallobiology of Alzheimer's disease

1 reference

12 December 2020

Copper and zinc promote interactions between membrane-anchored peptides of the metal binding domain of the prion protein

1 reference

12 December 2020

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Site-specific interactions of Cu(II) with alpha and beta-synuclein: bridging the molecular gap between metal binding and aggregation

1 reference

12 December 2020

A potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer's disease

1 reference

12 December 2020

1 reference

12 December 2020

Nanoparticle iron chelators: a new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance.

1 reference

12 December 2020

ALS: a disease of motor neurons and their nonneuronal neighbors

1 reference

12 December 2020

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

1 reference

12 December 2020

Blood zinc, copper and magnesium in aging. A study in healthy home-living elderly

1 reference

12 December 2020

Aluminum chelation: chemistry, clinical, and experimental studies and the search for alternatives to desferrioxamine

1 reference

12 December 2020

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

12 December 2020

Heme oxygenase expression in human central nervous system disorders

1 reference

12 December 2020

Furin is an endogenous regulator of alpha-secretase associated APP processing.

1 reference

12 December 2020

Prion protein potentiates acetylcholine release at the neuromuscular junction

1 reference

12 December 2020

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

1 reference

12 December 2020

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

1 reference

12 December 2020

Amyotrophic lateral sclerosis: A 40-year personal perspective

1 reference

12 December 2020

Antioxidant capacity in postmortem brain tissues of Parkinson's and Alzheimer's diseases.

1 reference

12 December 2020

Dietary copper and high saturated and trans fat intakes associated with cognitive decline

1 reference

12 December 2020

Metal deficiency increases aberrant hydrophobicity of mutant superoxide dismutases that cause amyotrophic lateral sclerosis

1 reference

12 December 2020

Zinc takes the center stage: its paradoxical role in Alzheimer's disease

1 reference

12 December 2020

Alzheimer's disease, metal ions and metal homeostatic therapy

1 reference

12 December 2020

Challenges associated with metal chelation therapy in Alzheimer's disease

1 reference

12 December 2020

Can copper binding to the prion protein generate a misfolded form of the protein?

1 reference

12 December 2020

Brain aging: The zinc connection.

1 reference

12 December 2020

The effect of aging on the mineral status of female mice

1 reference

12 December 2020

Therapeutic treatments for Alzheimer's disease based on metal bioavailability

1 reference

12 December 2020

Metal ions and oxidative protein modification in neurological disease.

1 reference

12 December 2020

HFE mutations and Alzheimer's disease

1 reference

12 December 2020

A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses.

1 reference

12 December 2020

The relevance of iron in the pathogenesis of Parkinson's disease.

1 reference

12 December 2020

Aluminum and Alzheimer's disease: a Vexata Questio between uncertain data and a lot of imagination.

1 reference

12 December 2020

The redox chemistry of the Alzheimer's disease amyloid beta peptide.

1 reference

12 December 2020

Aluminum modulates effects of beta amyloid(1-42) on neuronal calcium homeostasis and mitochondria functioning and is altered in a triple transgenic mouse model of Alzheimer's disease

1 reference

12 December 2020

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

1 reference

12 December 2020

Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein

1 reference

12 December 2020

Loss of in vitro metal ion binding specificity in mutant copper-zinc superoxide dismutases associated with familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Destabilization of non-pathological variants of ataxin-3 by metal ions results in aggregation/fibrillogenesis

1 reference

12 December 2020

Amyloid accumulation and pathogensis of Alzheimer's disease: significance of monomeric, oligomeric and fibrillar Abeta.

1 reference

12 December 2020

Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region.

1 reference

12 December 2020

The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Increased reactive oxygen species in familial amyotrophic lateral sclerosis with mutations in SOD1.

1 reference

12 December 2020

Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

1 reference

12 December 2020

Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease

1 reference

12 December 2020

Elevated manganese levels in blood and central nervous system occur before onset of clinical signs in scrapie and bovine spongiform encephalopathy.

1 reference

12 December 2020

Scavenger receptor class B type I expression and elemental analysis in cerebellum and parietal cortex regions of the Alzheimer's disease brain.

1 reference

12 December 2020

Loss of metal ions, disulfide reduction and mutations related to familial ALS promote formation of amyloid-like aggregates from superoxide dismutase

1 reference

12 December 2020

In vivo reduction of amyloid-beta by a mutant copper transporter

1 reference

12 December 2020

Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease

1 reference

12 December 2020

Zinc and cortical plasticity.

1 reference

12 December 2020

Aluminum complexing enhances amyloid beta protein penetration of blood-brain barrier.

1 reference

12 December 2020

Activation of iron regulatory protein-1 by oxidative stress in vitro

1 reference

12 December 2020

Normal prion protein has an activity like that of superoxide dismutase.

1 reference

12 December 2020

Copper in Alzheimer's disease: too much or too little?

1 reference

12 December 2020

Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance

1 reference

12 December 2020

Brain proteins that mind metals: a neurodegenerative perspective

1 reference

12 December 2020

A laser microprobe mass analysis of brain aluminum and iron in dementia pugilistica: comparison with Alzheimer's disease

1 reference

12 December 2020

Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation

1 reference

12 December 2020

Chelation therapy for neurodegenerative diseases

1 reference

12 December 2020

Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion

1 reference

12 December 2020

Serum zinc levels and Alzheimer's disease.

1 reference

12 December 2020

Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders

1 reference

12 December 2020

Expression of prion protein increases cellular copper binding and antioxidant enzyme activities but not copper delivery

1 reference

12 December 2020

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

1 reference

12 December 2020

A fatal case of aluminium encephalopathy in a patient with severe chronic renal failure not on dialysis

1 reference

12 December 2020

Brain copper content and cuproenzyme activity do not vary with prion protein expression level

1 reference

12 December 2020

Aluminium in Alzheimer's?

1 reference

12 December 2020

Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease.

1 reference

12 December 2020

Copper deficiency and neurological disorders in man and animals

1 reference

12 December 2020

Metal imbalance and compromised antioxidant function are early changes in prion disease

1 reference

12 December 2020

The dialysis encephalopathy syndrome. Possible aluminum intoxication

1 reference

12 December 2020

Role of iron in neurotoxicity: a cause for concern in the elderly?

1 reference

12 December 2020

Multivalent & multifunctional ligands to beta-amyloid

1 reference

12 December 2020

Immersion autometallographic tracing of zinc ions in Alzheimer beta-amyloid plaques

1 reference

12 December 2020

Neurochemical diagnosis of Alzheimer's dementia by CSF Abeta42, Abeta42/Abeta40 ratio and total tau.

1 reference

12 December 2020

The role of aluminum and copper on neuroinflammation and Alzheimer's disease

1 reference

12 December 2020

Zinc and Alzheimer's disease: is there a direct link?

1 reference

12 December 2020

Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD

1 reference

12 December 2020

Induction of cellular prion protein gene expression by copper in neurons

1 reference

12 December 2020

Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress.

1 reference

12 December 2020

Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia

1 reference

12 December 2020

Trace amounts of copper induce neurotoxicity in the cholesterol-fed mice through apoptosis.

1 reference

12 December 2020

Kinetic analysis of beta-amyloid peptide aggregation induced by metal ions based on surface plasmon resonance biosensing

1 reference

12 December 2020

Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease

1 reference

12 December 2020

Iron dysregulation and Parkinson's disease.

1 reference

12 December 2020

A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8

1 reference

12 December 2020

A novel approach to the identification and quantitative elemental analysis of amyloid deposits--insights into the pathology of Alzheimer's disease.

1 reference

12 December 2020

Iron, brain ageing and neurodegenerative disorders

1 reference

12 December 2020

Elevated manganese levels in blood and CNS in human prion disease

1 reference

12 December 2020

Mutual stimulation of beta-amyloid fibrillogenesis by clioquinol and divalent metals

1 reference

12 December 2020

10.1007/S12017-009-8102-1

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

19946766